Association of Bone Mineral Density and Coronary Artery Calcification in Patients with Osteopenia and Osteoporosis

Chuang, Tzyy‐Ling; Koo, Malcolm; Wang, Yuh-Feng

doi:10.3390/diagnostics10090699

Cited by 5 publications

(4 citation statements)

References 40 publications

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Section: Discussionsupporting

confidence: 93%

“…Our results are in line with previous studies which demonstrated a close relationship between osteoporosis and coronary atherosclerotic plaque 25 , 26 . A retrospective study of 246 Taiwan patients has noted that CAC is associated with osteoporosis 25 . The Copenhagen General Population study has shown an inverse relation between BMD and CAC in both men and postmenopausal women 26 .…”

Section: Discussionsupporting

confidence: 93%

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Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals

Park

Lee

Yoon

2022

Sci Rep

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Osteoporosis and sarcopenia are substantially interrelated with shared cardiovascular risk factors. However, the relationship between osteosarcopenia and coronary artery disease is largely unexplored. We aimed to investigate the association between osteosarcopenia and coronary artery calcification (CAC) scores in asymptomatic adults. A total of 5969 asymptomatic adults without cardiovascular disease who underwent a health examination including estimation of CAC scores by cardiac tomography were analyzed. Osteoporosis was defined as low bone mineral density T-score ≤ − 2.5 standard deviation, and sarcopenia as appendicular skeletal muscle mass < 5.7 kg/m2 for women and < 7.0 kg/m2 for men, and osteosarcopenia as the copresence of both osteoporosis and sarcopenia. Participants were divided into four groups according to the presence of osteoporosis and/or sarcopenia as control, sarcopenia alone, osteoporosis alone, and osteosarcopenia. Prevalence of CAC was 22.0% in control, 23.6% in sarcopenia alone, 38.5% in osteoporosis alone, and 48.3% in osteosarcopenia group, with the osteosarcopenia group showing the highest (p < 0.0001). After adjustments for possible confounders, mean of log (CAC score + 1) in osteosarcopenia group was higher than other three groups (Bonferroni p < 0.0001). Using multivariate-adjusted analysis, subjects with osteosarcopenia had the highest risk for having CAC > 0 (odds ratio [OR] 2.868; 95% confidence interval [CI] 1.717–4.790). Furthermore, subjects with osteosarcopenia had a significant risk of moderate-to-extensive CAC (CAC score ≥ 100) (OR 2.709; 95% CI 1.128–6.505). We demonstrated that osteosarcopenia was independently associated with a higher prevalence of subclinical coronary atherosclerosis. Our results suggest osteosarcopenia as a predisposing factor for coronary heart disease.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals

Park

Lee

Yoon

2022

Sci Rep

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“…33 , 34 In a cross-sectional study, a significantly negative association was found between CACs and BMD of lumbar spine, but not total hip. 35 However, another study reported that a significant association of CACs with an increase of osteoporotic fracture and hip fracture risk. 36 These studies implied that the included subjects and BMD sites may be critical when analyzing the association of these two.…”

Section: Discussionmentioning

confidence: 99%

Association Between Coronary Artery Calcium Score and Bone Mineral Density in Type 2 Diabetes Mellitus with Different Visceral Fat Area

Yang¹,

Zhang²,

Ye³

et al. 2022

DMSO

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Purpose The relationship between coronary artery calcification and bone mineral density (BMD) in T2DM is still unclear. The aim of this study is to analyze the association between coronary artery calcium score (CACs) and BMD in T2DM with different visceral fat area (VFA), and further to explore the clinical significance of CACs in predicting osteoporosis in T2DM patients. Patients and Methods A total of 479 T2DM patients aged ≥50 years were included. Agatston was applied to calculate CACs to evaluate the degree of coronary artery calcification. Dual-energy X-ray absorptiometry (DXA) was used to measure BMD. According to VFA, all subjects were divided into VFA <100cm 2 and VFA ≥100cm 2 group. Adjusted regression analysis was performed to analyze the association between CACs and BMD. ROC curve was used to analyze the optimal cut-off value of CACs for screening osteoporosis. Results The baseline showed that in VFA ≥100cm 2 group, CACs increased significantly than that in VFA <100cm 2 group (212.1±195.9 vs 139.3±141.8, p <0.001) and total hip BMD decreased obviously (0.968±0.19 vs 1.021±0.184, p =0.01). After multivariable adjustment, CACs was not significantly associated with BMD in all patients ( p >0.05). However, CACs was negatively associated with BMD of total hip and lumbar spine in patients with VFA ≥100cm 2 (total hip β=−0.087 p =0.01; lumbar spine β=−0.052 p =0.005), but not VFA <100cm 2 . ROC curve analysis showed that the optimal cut-off value of CACs for screening osteoporosis was 191.505. Conclusion The present study implied that associations between CACs and BMD varied by the visceral fat deposition. It is critical to evaluate the condition of visceral fat accumulation for exploring the complex interplay of coronary artery calcification and BMD in T2DM patients. It may be of some clinical value for CACs in predicting osteoporosis in T2DM with visceral obesity.

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“…In our previous retrospective medical review study on 246 adult patients, no significant independent associations were observed between BMD of the lumbar spine, femoral neck, or total hip with a moderate or high CAC score in patients with osteopenia. In patients with osteoporosis, only the BMD of the lumbar spine was significantly and inversely associated with moderate CAC score [ 22 ]. In addition, we previously reported that TBS was independently associated with moderate but not high CAC scores [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Trabecular Bone Score-Adjusted Fracture Risk Assessment Tool with Coronary Artery Calcification in Women

et al. 2022

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The trabecular bone score (TBS) was found to be significantly associated with moderate coronary artery calcification (CAC). The aim of this study was to further explore the association between TBS-adjusted Fracture Risk Assessment Tool (FRAX) and CAC score in women. The electronic medical record database of a regional teaching hospital in southern Taiwan yielded women who received both coronary computed tomography and bone mineral density (BMD) measurement during their general health examination. Health history, anthropomorphic measurements, laboratory results, BMD, and T-scores were obtained. TBS values were calculated from database spine dual-energy X-ray absorptiometry files. Linear regression analyses tested the association between CAC score and 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF) determined by TBS-adjusted FRAX. Of the 116 women (mean age 55.8 years) studied, 24.1% had osteoporosis. Simple linear regression showed a significant association of CAC score with an increase in MOF and HF risk as measured by TBS-adjusted FRAX. In multiple linear regression adjusted for potential confounders, CAC score remained significantly associated with TBS-adjusted FRAX for right MOF (p = 0.002), left MOF (p = 0 006), right HF (p = 0.005), and left HF (p = 0.015). In conclusion, clinicians should be vigilant to the potential increased risk of coronary events among women with increased TBS-adjusted FRAX for MOF and HF.

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Association of Bone Mineral Density and Coronary Artery Calcification in Patients with Osteopenia and Osteoporosis

Cited by 5 publications

References 40 publications

Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals

Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals

Association Between Coronary Artery Calcium Score and Bone Mineral Density in Type 2 Diabetes Mellitus with Different Visceral Fat Area

Association of Trabecular Bone Score-Adjusted Fracture Risk Assessment Tool with Coronary Artery Calcification in Women

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