Association of Changes in Neural Targets and Dietary Outcomes among Patients with Comorbid Obesity and Depression: Post hoc Analysis of ENGAGE-2 Mechanistic Clinical Trial

Lv, Nan; Hallihan, Hagar; Xiao, Lan; Williams, Leanne M.; Ajilore, Olusola; Ma, Jun

doi:10.1016/j.tjnut.2023.01.022

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…However, the increased RSFC in the dlPFC predicted an improvement in loss of control and binge eating or overeating behaviours, analogous to previous results that showed increased dlPFC activity of the cognitive control circuit predicted dietary improvements. 26 …”

Section: Discussionmentioning

confidence: 99%

Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa

He,

Zheng,

Zhang

et al. 2024

Gen Psych

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BackgroundAnorexia nervosa (AN) has been characterised as a psychiatric disorder associated with increased control. Currently, it remains difficult to predict treatment response in patients with AN. Their cognitive abilities are known to be resistant to treatment. It has been established that the frontoparietal control network (FPCN) is the direct counterpart of the executive control network. Therefore, the resting-state brain activity of the FPCN may serve as a biomarker to predict treatment response in AN.AimsThe study aimed to investigate the association between resting-state functional connectivity (RSFC) of the FPCN, clinical symptoms and treatment response in patients with AN.MethodsIn this case-control study, 79 female patients with AN and no prior treatment from the Shanghai Mental Health Center and 40 matched healthy controls (HCs) were recruited from January 2015 to March 2022. All participants completed the Questionnaire Version of the Eating Disorder Examination (version 6.0) to assess the severity of their eating disorder symptoms. Additionally, RSFC data were obtained from all participants at baseline by functional magnetic resonance imaging. Patients with AN underwent routine outpatient treatment at the 4th and 12th week, during which time their clinical symptoms were evaluated using the same measures as at baseline.ResultsAmong the 79 patients, 40 completed the 4-week follow-up and 35 completed the 12-week follow-up. The RSFC from the right posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (dlPFC) increased in 79 patients with AN vs 40 HCs after controlling for depression and anxiety symptoms. By multiple linear regression, the RSFC of the PPC to the inferior frontal gyrus was found to be a significant factor for self-reported eating disorder symptoms at baseline and the treatment response to cognitive preoccupations about eating and body image, after controlling for age, age of onset and body mass index. The RSFC in the dlPFC to the middle temporal gyrus and the superior frontal gyrus may be significant factors in the treatment response to binge eating and loss of control/overeating in patients with AN.ConclusionsAlterations in RSFC in the FPCN appear to affect self-reported eating disorder symptoms and treatment response in patients with AN. Our findings offer new insight into the pathogenesis of AN and could promote early prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa

He,

Zheng,

Zhang

et al. 2024

Gen Psych

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Depression and Obesity—Do We Know Everything about It? A Narrative Review

Dębski,

Przybyłowski,

Skibiak

et al. 2024

Nutrients

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Introduction: Due to similarities in their pathophysiology and common psychological background, depressive disorders and obesity often occur simultaneously. The treatment of obesity can reduce the symptoms of comorbid depression and, conversely, treating depression can improve weight reduction outcomes. Purpose of this study: This review aimed to analyze the available literature on the subject of various methods of treating obesity and comorbid depression and to demonstrate the mutual correlation between the therapy of depressive disorders and the therapy of obesity. Method: The Pubmed and Cochrane databases were searched for original articles on the subject of simultaneous depression and obesity that had been published between 2014 and 2024, using the key words “depression”, “depressive symptoms”, “obesity”, and “behavioral therapy”. Results and conclusions: The successful treatment of depression can help in treating obesity, especially in motivating patients to adjust their lifestyle by changing dietary habits and increasing their physical activity, which contribute to both changes in body mass index scores and reductions in depressive symptoms. Changes in self-perception, reduced daily stress, and dietary changes, as well as increased physical activity, contribute to both weight loss and the reduction of depressive symptoms. Depression and obesity should be treated as one two-dimensional disorder to achieve better long-term treatment results.

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Association of Changes in Neural Targets and Dietary Outcomes among Patients with Comorbid Obesity and Depression: Post hoc Analysis of ENGAGE-2 Mechanistic Clinical Trial

Cited by 2 publications

References 61 publications

Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa

Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa

Depression and Obesity—Do We Know Everything about It? A Narrative Review

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