Association of Circulating immune Complexes in the development of Visceral Leishmianisis

AL-Fakhar, Suha A.; Ali, Wifaq M.; Obaid, Khitam Yahya; Mohammed, Khalil Ismail Abid; Ali, Saad Hasan Mohammed; Mousa, Jinan M.

doi:10.5958/0974-360x.2020.00582.x

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CIC were found in 30% of sera from human patients with VL. They were also detected in sera from patients with cutaneous leishmaniasis and persist in sera from clinically cured subjects [ 52 ]. These studies suggest that disease complications may be partly accounted for by CIC deposition-related pathology, particularly nephritis [ 27 , 29 , 53 , 54 , 55 ].…”

Section: Role Of Cic In Canlmentioning

confidence: 99%

Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

Cacheiro-Llaguno¹,

Parody²,

Escutia³

et al. 2021

Microorganisms

View full text Add to dashboard Cite

During canine visceral leishmaniasis (CanL), due to Leishmania infantum (L. infantum), uncontrolled infection leads to a strong humoral immune response. As a consequence of the production of high antibody levels and the prolonged presence of parasite antigens, circulating immune complexes (CIC) are formed, which can be deposited in certain organs and tissues, inducing vasculitis, uveitis, dermatitis and especially glomerulonephritis and renal failure. A method to detect CIC and quantify their levels in serum samples from dogs infected with L. infantum has been recently described. It allowed demonstration of a correlation between CIC levels and disease severity. Thus, CIC measurement may be useful for diagnosis, assessment of disease progression and monitoring response to treatment. This is an interesting finding, considering that there remains an urgent need for identification of novel biomarkers to achieve a correct diagnosis and for optimal disease staging of dogs suffering from Leishmania infection. The objective of the present review is to shed light on the role of CIC in CanL, as well as to highlight their potential use not only as diagnostic and prognostic biomarkers but also as a valuable tool in vaccine development and new immunotherapy strategies to prevent or control disease outcome.

show abstract

Section: Role Of Cic In Canlmentioning

confidence: 99%

Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

Cacheiro-Llaguno¹,

Parody²,

Escutia³

et al. 2021

Microorganisms

View full text Add to dashboard Cite

show abstract

The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis

Campelo,

Medvedovsky,

de Holanda

et al. 2024

Indian J Microbiol

View full text Add to dashboard Cite

Evaluation of Two Assays Immunochromatography and RT-PCR for detection of Rotavirus in Iraqi Children

Zaboon

Mohammed

Muhammed

et al. 2023

RJPT

View full text Add to dashboard Cite

The lack of dedicated RV treatment makes early detection and effective vaccines important to prevent increased mortality and morbidity, as they can only be treated with fluid and electrolyte replacement. The study's goal was to assess the specificity and sensitivity of Reverse transcriptase PCR and Rapid immunochromatography techniques for Rotavirus detection. Between November 2020 and June 2021, 320 stool samples from children under the age of five were obtained at Babylon Teaching Hospital. Primary detection of Rotavirus contamination has executed the use of immunochromatography test (rapid test) LumiQuickAdeno-RotaVirus Antigen Comb takes a look at(Netherlands) and opposite transcriptase PCR in the detection of Rotavirus infection by means of using structural gene (vp4), the results discovered that Rotavirus became detected at a high rate in male stool samples (67.5%) rather than a girl (32.5%). December and Januarywere observed the biggest number of cases, with (46.6%) and (28.3%), respectively.The rural area had the highest rate of Rotavirus infection (56.6%), compared to (43.4%) in the urban area.The RT-PCR assay's excellent overall performance was also considered in its capability to identify Rotavirus RNA in 84 of 320 children's prevalence (26.25%).

show abstract

Association of Circulating immune Complexes in the development of Visceral Leishmianisis

Cited by 3 publications

References 0 publications

Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis

Evaluation of Two Assays Immunochromatography and RT-PCR for detection of Rotavirus in Iraqi Children

Contact Info

Product

Resources

About