Association of Different Pathologic Processes of the Thyroid Gland in Fine Needle Aspiration Samples

Zeppa, Pio; Benincasa, Giulio; Lucariello, A; Palombini, Lucio

doi:10.1159/000327629

Cited by 29 publications

(19 citation statements)

References 24 publications

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“…1 However, the performance of FNA is not totally reliable when a monotonous population of 3-dimensional groups of follicular cells with scarce colloid is aspirated. 2 In such cases, the cytologic distinction between hyperplastic lesions and benign and malignant neoplasms is unsure.…”

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confidence: 99%

Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine‐needle aspirates suspicious for Hurthle cell neoplasms

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Volante

Iaccarino

et al. 2009

Cancer Cytopathology

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BACKGROUND:Thyroid fine‐needle aspiration (FNA) samples that feature a follicular‐patterned, monotonous Hurthle (oncocytic) cell population cannot be diagnosed reliably. The authors of this report recently identified cyclin D3 overexpression on histologic sections of Hurthle cell carcinoma. In this study, they assessed the diagnostic value of cyclin D3 immunohistochemistry added to routine cytology.METHODS:Fifty‐one FNA samples that were suspicious for Hurtle cell neoplasia and that had histologic follow‐up (19 malignant cases) were examined. Cyclin D3 expression levels were evaluated in cell block preparations and were compared with levels of the closely related cyclin D1 protein.RESULTS:Greater than 25% positive cells were used as the cutoff point, as suggested by previous studies. Cyclin D1 and cyclin D3 were highly specific (100% for both) and fairly accurate (75% and 92%, respectively) in distinguishing between benign and malignant oncocytic lesions; the positive predictive value (PPV) for each was 100%. However, both cyclins D1 and D3 had low sensitivity (32% and 79%, respectively) and low negative predictive value (NPV) (71% and 89%, respectively). In contrast, by adopting balanced receiver operating characteristic‐derived positive cutoff values, cyclin D1 (≥6.5%) and cyclin D3 (≥7.5%) were found to be highly sensitive (100% for both) and accurate (90% and 94%, respectively); and the NPV was 100% for both. In contrast, cyclins D1 and D3 had low specificity (84% and 91%, respectively) and a low PPV (79% and 86%, respectively); however, these values improved in samples that were positive for both cyclins (sensitivity, 100%; specificity, 94%; PPV, 90%; NPV, 100%; and accuracy, 96%).CONCLUSIONS:Cyclin D3 increased the suspicion of malignancy in indeterminate oncocytic lesions; its diagnostic performance depended on the cutoff point used and was enhanced further when combined with cyclin D1. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society.

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confidence: 99%

Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine‐needle aspirates suspicious for Hurthle cell neoplasms

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Volante

Iaccarino

et al. 2009

Cancer Cytopathology

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“…One of the DiffQuik-stained smears was destained, Feulgen restained and evaluated for DNA ploidy, as reported elsewhere. 15 The smears showed groups of medium-sized, undifferentiated cells showing nuclei with dense and coarse chromatin, indistinct nulcleoli and thin cytoplasm lacking granules and vacuoles (Figure 1). Occasional mitotic figures were present; neither necrosis nor fragments of fibrosis were observed in the smears.…”

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Occult Lymph Node Metastasis from Desmoplastic Small Round Cell Tumor Diagnosed by Fine Needle Aspiration Cytology

Zeppa

Lepore²,

Vetrani³

et al. 2003

Acta Cytologica

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“…4 With regard to the FCHCTs, we observed that the corresponding mean nuclear area (measured in m 2 ) was the smallest, with the lowest standard deviation (78.14 6 14.72) compared with the goiters (86.86 6 20.81), thyroiditis lesions (95.29 6 24.63) and the adenoma lesions (93.08 6 26.86). These differences were statistically significant between carcinoma and adenoma lesions, whereas they were not between carcinoma and goiter.…”

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confidence: 77%

Fine‐needle cytology of Hürthle cell tumors and morphometry

Zeppa

Vitale

2014

Cancer Cytopathology

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Association of Different Pathologic Processes of the Thyroid Gland in Fine Needle Aspiration Samples

Cited by 29 publications

References 24 publications

Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine‐needle aspirates suspicious for Hurthle cell neoplasms

Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine‐needle aspirates suspicious for Hurthle cell neoplasms

Occult Lymph Node Metastasis from Desmoplastic Small Round Cell Tumor Diagnosed by Fine Needle Aspiration Cytology

Fine‐needle cytology of Hürthle cell tumors and morphometry

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