Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure

Lin, Zhongxiao; Chang, Jishuo; Li, Xinzhi; Wang, Jianglin; Wu, Xia; Liu, Xiaoyan; Zhu, Yi‐Zhun; Yu, Xiang

doi:10.1007/s10142-021-00813-9

Cited by 8 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To further clarify the main targets by which DA treats VS, the top 25 nodes were ranked by the MCC , DMNC , EPC , and Radiality algorithms of the cytoHubba tool in Cytoscape 3.8.0 to explore meaningful modules for targets (Figure 2E–H). cytoHubba is widely used to predict and explore key nodes and subnetworks in a given network, which has been reported before 20 . In general, proteins with a high degree tend to be critical proteins.…”

Section: Resultsmentioning

confidence: 98%

“…The STRING website (https://www.string-db.org/) and Cytoscape software (topology parameters of Network Analyzer) 3.8.0 were used to map targets of DA action against VS and to harvest a target‐to‐target function‐related protein network, PPI. Moreover, the best targets were selected based on degree values 20 …”

Section: Methodsmentioning

confidence: 99%

“…cytoHubba is widely used to predict and explore key nodes and subnetworks in a given network, which has been reported before. 20 In general, proteins with a high degree tend to be critical proteins. The Venn diagram exhibited an interaction of these four methods highlighting genes, showing that eight proteins, HDAC1, cyclin B1 (CCNB1), mitogen-activated protein kinase kinase 1 (MAP2K1), cyclin-dependent kinase 4 (CDK4), (MDM2), androgen receptor (AR), mechanistic target of rapamycin kinase (mTOR), and progesterone receptor (PGR), were hub targets (Figure 2I).…”

Section: Network Pharmacology-based Uncovering Of Compound-disease-ta...mentioning

confidence: 99%

See 2 more Smart Citations

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Lin,

He,

Xian

et al. 2023

MedComm

Self Cite

View full text Add to dashboard Cite

Aconitum carmichaelii (Fuzi) is a traditional Chinese medicine that has been widely used in the clinic to save the dying life for over several thousand years. However, the medicinal components of Fuzi in treating vascular senescence (VS) and its potential mechanism remain unclear. In this study, a network pharmacology method was used to explore the possible components and further validated by experiments to get a candidate compound, deoxyandrographolide (DA). DA restrains aging biomarkers, such as p16, p21, γH2A.X, and p53 in vitro and in vivo blood co‐culture studies. Histone deacetylase 1 (HDAC1), mouse double minute2 (MDM2), cyclin‐dependent kinase 4, and mechanistic target of rapamycin kinase (mTOR) are predicted to be the possible targets of DA based on virtual screening. Subsequent bio‐layer interferometry results indicated that DA showed good affinity capability with HDAC1. DA enhances the protein expression of HDAC1 in the angiotensin II‐induced senescence process by inhibiting its ubiquitination degradation. Loss of HDAC1 by CRISPR/Cas9 leads to the disappearance of DA's anti‐aging property. The enhancement of HDAC1 represses H3K4me3 (a biomarker of chromosomal activity) and improves chromosome stability. RNA sequencing results also confirmed our hypothesis. Our evidence illuminated that DA may achieve as a novel compound in the treatment of VS by improving chromosome stability.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Network Pharmacology-based Uncovering Of Compound-disease-ta...mentioning

confidence: 99%

See 1 more Smart Citation

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Lin,

He,

Xian

et al. 2023

MedComm

Self Cite

View full text Add to dashboard Cite

show abstract

“…В миокарде при СН у пациентов с КМП (ДКМП, обструктивной ГКМП и ИКМП) установлен повышенный уровень экспрессии ДНК-метилтрансфераз, ответственных за метилирование ДНК de novo: DNMT3Aв 1,3 раза, DNMT3B -в 2,1 раза [17]. На животных моделях (мыши) показано, что после инфаркта в миокарде регистрируют изменение экспрессии ряда генов, белковые продукты которых участвуют как в модификации гистонов (Mettl11b, HDAC3, HDAC11 и генов, связанных с убиквитинированием), так и кодирующих регуляторные РНК (в частности малые ядрышковые РНК -snoRNAs), которые авторы отнесли к числу новых регуляторов при СН [18].…”

Section: эпигенетические факторы в развитии снunclassified

Epigenetic factors of heart failure (review)

Kucher,

Nazarenko

2024

SJCEM

View full text Add to dashboard Cite

Heart failure (HF) is a widespread syndrome that leads to a significant decrease in the quality of life of patients. Epigenetics is one of the most promising areas of HF research, which allows us to consider the pathogenesis of this syndrome at a new molecular level. This review summarizes the studies of epigenetic processes (histone modification, DNA methylation, changes in the expression of regulatory non-coding RNAs) that accompany HF development. Epigenetic studies of HF not only confirmed the clinical and etiological heterogeneity of this syndrome, but also expanded the range of potential diagnostic markers and opened up new drug development strategies.

show abstract

“…In addition, a fructose injury-induced mouse model of diabetic heart failure that lacks HDAC11 had lower levels of apoptosis, dyslipidemia, inflammation, and oxidative stress ( 102 ). HDAC11 has also been suggested to be an essential regulator in heart failure ( 103 ). Therefore, HDAC11 contributes to the pathogenesis of diabetic Cardiopathy.…”

Section: Hdac11 In Diabetesmentioning

confidence: 99%

HDAC11, an emerging therapeutic target for metabolic disorders

et al. 2022

View full text Add to dashboard Cite

Histone deacetylase 11 (HDAC11) is the only member of the class IV HDAC, and the latest member identified. It is highly expressed in brain, heart, kidney and some other organs, and located in mitochondria, cytoplasm and nuclei, depending on the tissue and cell types. Although studies in HDAC11 total knockout mice suggest its dispensable features for tissue development and life, it participates in diverse pathophysiological processes, such as DNA replication, tumor growth, immune regulation, oxidant stress injury and neurological function of cocaine. Recent studies have shown that HDAC11 is also critically involved in the pathogenesis of some metabolic diseases, including obesity, diabetes and complications of diabetes. In this review, we summarize the recent progress on the role and mechanism of HDAC11 in the regulation of metabolic disorders, with the focus on its regulation on adipogenesis, lipid metabolism, metabolic inflammation, glucose tolerance, immune responses and energy consumption. We also discuss the property and selectivity of HDAC11 inhibitors and their applications in a variety of in vitro and in vivo models of metabolic disorders. Given that pharmacological and genetic inhibition of HDAC11 exerts a beneficial effect on various metabolic disorders, HDAC11 may be a potential therapeutic target to treat chronic metabolic diseases.

show abstract

Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure

Cited by 8 publications

References 50 publications

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Epigenetic factors of heart failure (review)

HDAC11, an emerging therapeutic target for metabolic disorders

Contact Info

Product

Resources

About