Association of Elevated Plasma Total Homocysteine With Dementia With Lewy Bodies: A Case-Control Study

Zhang, Guili; Liu, Shuai; Chen, Zhichao; Shi, Zhihong; Hu, Wenzheng; Ma, Lulin; Wang, Xiaodan; Li, Xudong; Ji, Yong

doi:10.3389/fnagi.2021.724990

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…We generated Kaplan-Meier survival curves using the median survival time from disease onset and the first visit were 81 (95% CI 69.09-92.91) and 45 (95% CI 34.78-55. 22) months, respectively. The median survival time from the first visit to death in mild dementia and moderate to severe dementia was comparable at 59 (95% CI 34.32-83.68) and 41 (95% CI 30.15-51.85) months, respectively (log-rank χ 2 = 7.76, p < 0.005) (Figure 2).…”

Section: Survival Time From First Visit and Disease Onset By Groupsmentioning

confidence: 93%

“…Visual hallucinations, specifically formed and detailed visual hallucinations and illusions, that were complained about by the patient and/or caregiver were determined by confirmation and quantification according to the hallucinations item of the Neuropsychiatric Inventory scores (NPI) 20,21 . Parkinsonism was rated as present when the neurological exam showed extrapyramidal signs (tremor, bradykinesia, and/or rigidity) 22 . RBD was confirmed by caregivers who noted five or more behaviors that are mentioned in the RBD screening questionnaire (RBD‐SQ) or by someone who was diagnosed using overnight video polysomnography 23,24 …”

Section: Methodsmentioning

confidence: 99%

“…20,21 Parkinsonism was rated as present when the neurological exam showed extrapyramidal signs (tremor, bradykinesia, and/or rigidity). 22 RBD was confirmed by caregivers who noted five or more behaviors that are mentioned in the RBD screening questionnaire (RBD-SQ) or by someone who was diagnosed using overnight video polysomnography. 23,24…”

Section: Dlb Core and Suggestive Clinical Features And Indicative Bio...mentioning

confidence: 99%

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Survival and causes of death among people with clinically diagnosed dementia with Lewy bodies: A multicenter cohort study

Zuo

Yue

Zhang

et al. 2022

Int J Geriat Psychiatry

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Objective A comprehensive study of the survival and causes of death of people with clinically diagnosed Dementia with Lewy bodies (DLB) were few. The aim of our study was to investigate the survival and causes of death of DLB. Methods The patients diagnosed with probable DLB were consecutively enrolled from five memory clinics in China across a 5‐year period (2017–2021) with mortality data updated to December 2021. The endpoint was all‐cause death. Survival analysis including Cox regression by groups (time both from disease onset and the first visit to death) and causes of death were evaluated. Results Of the 108 patients with DLB, 54 (50%) were men and the time from onset of disease to the first visit to the memory clinic (lag time) was 24 (12–48) months. During follow‐up, 28.7% (n = 31) of the patients died. The median survival time both from disease onset and the first visit were 81 (95% cognitive impairment (CI) 69.09–92.91) and 45 (95% CI 34.78–55.22) months, respectively. The use of antipsychotic drugs (HR 0.15, 95% CI: 0.03–0.75), moderate to severe dementia (Clinical Dementia Rating [CDR]) at the first visit (HR 0.22, 95% CI 0.78 to 0.62) and the longer lag time (HR 0.943, 95% CI 0.92–0.97) predicted a shorter survival. Failure to thrive (stopped eating, drinking) or multiple organ dysfunction syndrome (MODS) maybe the most common cause of death (41.7%), followed by pneumonia or aspiration (29.2%). Conclusions The factors associated with survival time were disease severity level, antipsychotic drug use and lag time to seek medical advice. Failure to thrive or MODS and pneumonia were probably the most common cause of death. The long‐term outcomes of DLB patients may be helpful to guide clinicians counseling patients and caregivers.

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Section: Survival Time From First Visit and Disease Onset By Groupsmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Dlb Core and Suggestive Clinical Features And Indicative Bio...mentioning

confidence: 99%

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Survival and causes of death among people with clinically diagnosed dementia with Lewy bodies: A multicenter cohort study

Zuo

Yue

Zhang

et al. 2022

Int J Geriat Psychiatry

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“…Zhang et al [ 115 ] recently performed a retrospective case–control study including 132 dementia with Lewy body (LBD) patients, 264 AD patients, and 295 age-matched healthy controls. They found that elevated plasma tHCy levels were associated with LBD, and more strongly so than with AD.…”

Section: Homocysteine and Degenerative Brain Diseasesmentioning

confidence: 99%

“…Work published later than 2000, which we review below, kept neglecting the issue. Most of the studies exploring the role of HCy levels on the dementias do not report data from multi-domain neuropsychological examination [ 85 , 86 , 88 , 89 , 92 , 93 , 95 , 98 , 99 , 102 , 103 , 104 , 105 , 109 , 112 , 115 , 116 , 117 , 118 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 ]. Typically, authors focus on the general cognitive status of the patient, and thus report data from neuropsychological screening tools, such as the Mini Mental State Examination (MMSE).…”

Section: Homocysteine and Cognitive Functionsmentioning

confidence: 99%

Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art

et al. 2022

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There is strong evidence that homocysteine is a risk factor not only for cerebrovascular diseases but also for degenerative dementias. A recent consensus statement renewed the importance and the role of high levels of homocysteine in cognitive decline in several forms of degenerative dementia, such as Alzheimer’s disease. Although the molecular mechanisms by which homocysteine causes cell dysfunction are known, both the impact of homocysteine on specific cognitive functions and the relationship between homocysteine level and non-Alzheimer dementias have been poorly investigated. Most of the studies addressing the impact of hyperhomocysteinemia on dementias have not examined the profile of performance across different cognitive domains, and have only relied on screening tests, which provide a very general and coarse-grained picture of the cognitive status of the patients. Yet, trying to understand whether hyperhomocysteinemia is associated with the impairment of specific cognitive functions would be crucial, as it would be, in parallel, learning whether some brain circuits are particularly susceptible to the damage caused by hyperhomocysteinemia. These steps would allow one to (i) understand the actual role of homocysteine in the pathogenesis of cognitive decline and (ii) improve the diagnostic accuracy, differential diagnosis and prognostic implications. This review is aimed at exploring and revising the state of the art of these two strictly related domains. Suggestions for future research are provided.

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Risk factors for the alzheimer's disease. Systematic review and meta-analysis

Khasanova,

Muzaffarova

2024

Fundamentalʹnaâ i kliničeskaâ medicina

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The “aging” of the population increased the importance of researches in the field of the epidemiology of chronic diseases, including Alzheimer's disease (AD) -the most common cause of dementia in the population.Aim. The role of potential risk factors for AD through a systematic review and meta-analysis. The “aging” of the population has updated research in the field of the epidemiology of chronic diseases, incl. Alzheimer's disease (AD) is the most common cause of dementia in the population. The aim of the study was to assess the role of potential risk factors for AD through a systematic review and meta-analysis.Materials and Methods. Using the electronic databases PubMed, Scopus, E-library, a search was made for articles in Russian and English, published from 1995 to 2022. In accordance with the clinical question, using the PECO formula, papers were selected in which the authors investigated the role of various risk factors in groups with and without AD. The study was carried out in accordance with the international guidelines for writing systematic reviews and meta-analyses "PRISMA". Study quality was analyzed using the Newcastle-Ottawa scale for cohort and case-control studies. The degree of heterogeneity was assessed using the chi-square test and the I2 coefficient. Publication bias was analyzed using a funnel plot. We used the software Review Manager 5.3 and Microsoft Office Excel 2010.Results. Initially, 3197 articles were retrieved from the databases; After screening and eligibility analysis, 17 studies were included in the me-ta-analysis (11 case-control studies and 6 cohort studies). Totally, these publications included data from 134,732 people with a confirmed diagnosis of AD and 1,058,143 respondents without AD (control group). According to the results of the meta-analysis, significant risk factors were: heredity (odds ratio (OR) 1.82; 95% confidence interval (95% CI) 1.66-1.99), arterial hypertension (OR 1.65; 95% CI 1.29-2.13), hypercholesterolemia (OR 1.25; 95% CI 1.13-1.38), obesity (OR 1.13; 95% CI 1.09-1.17), presence of diabetes mellitus 2 type (OR 1.36; 95%; CI 1.15-1.62), low level of education (OR 1.61; 95% CI 1.18-2.18), depression (OR 1.35; 95% CI 1.03-1.76). There was no relationship with alcohol consumption, smoking, a history of myocardial infarction and / or coronary heart disease, a history of acute cerebrovascular accident, insomnia, female gender, traumatic brain injury.Conclusion. The conducted meta-analysis allowed to obtain confirmation of the role of various potential risk factors for AD; at the same time, many of them are modifiable and are associated with metabolic disorders, which can probably be involved into the process of accumulation and deposition of beta-amyloid in the cells of the nervous system. Continued research on this issue could contribute to the development of prognostic scales and personalized recommendations for the prevention of this currently incurable disease.

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Association of Elevated Plasma Total Homocysteine With Dementia With Lewy Bodies: A Case-Control Study

Cited by 7 publications

References 34 publications

Survival and causes of death among people with clinically diagnosed dementia with Lewy bodies: A multicenter cohort study

Survival and causes of death among people with clinically diagnosed dementia with Lewy bodies: A multicenter cohort study

Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art

Risk factors for the alzheimer's disease. Systematic review and meta-analysis

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