Association of end‐stage renal disease with HLA phenotypes and panel reactive antibodies in patients awaiting renal transplantation in Hunan Province

Abstract

Kidney transplantation using organs from relatives or donors is one of the main treatment methods for patients with end-stage renal disease (ESRD). 1 Human leukocyte antigens (HLAs), which are cell-surface proteins encoded by the major histocompatibility complex in the human body, act mainly to regulate the immune response and immune regulatory functions. The HLA genes, which are highly polymorphic, determine the compatibility of transplanted tissue with the recipient's HLA phenotype, and their expression is closely

Association between End-stage renal disease and the polymorphism of HLA in Guangxi Zhuang population

“…Our investigation was conducted without consideration for primary renal disease resulting in ESRD, as in some described studies [21][22][23][24][25]27], which is our study's one limitation. The other main limitations of this study were the small number of HLA loci and the patient sample size, which called for further research with larger patient samples, more HLA loci, and every condition that could cause ESRD.…”

“…However, susceptible alleles should receive more attention because they are signi cantly more common in ESRD patients than controls, making it more di cult to match patients with kidney transplants.In some studies, HLA alleles and ESRD are signi cantly correlated, but most research uses low-resolution HLA typing. HLA-A*24 and HLA-B*35 may be protective alleles for patients with ESRD in Indonesia[21]; HLA-B*50 may be susceptible to ESRD in Pakistan, whereas HLA-B*40, DRB1*13, and DRB1*12 may be protective alleles for patients with ESRD[22] ; HLA-DRB1*4 and DRB1*11 may be susceptible alleles for patients with ESRD in the Henan Han population of China, whereas HLA-B*62 and DRB1*15 may be protective alleles for patients with ESRD[23]; HLA-B8 may be a susceptible allele to ESRD in Kuwaiti patients, and HLA-A28 and HLA-DR11 may be protective alleles for patients with ESRD[24]; HLA-A2, -B48, -B52, and -B55 were positively associated with ESRD in the Hunan Han population of China, whereas HLA-B60 was negatively associated with ESRD[25];HLA-A*24, B*54, B*55, B*60, and DRB1*04 may be susceptible alleles to ESRD in Chinese Cantonese patients with ESRD[26]; HLA-B*15 and B*18 may be susceptible alleles to ESRD in Saudi Arabian patients, whereas HLA-A*26, B*39, and B*50 may be protective alleles for patients with ESRD[27]; DRB1*03 and DRB1*11 in Taiwanese were markers for ESRD development…”