Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency

Genetic variants in the plasminogen activator inhibitor‐1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients

“…The rs7242 polymorphism is located in the 3′‐UTR of PAI‐1 and is characterized by the substitution of a guanine with thymine. Studies have examined the relationships between this polymorphism and the risk of myocardial infarction, diffuse‐type gastric cancer susceptibility, and primary ovarian insufficiency . In addition, previous studies found that haplotypes of this polymorphism may affect the plasma level of PAI‐1 .…”

“…Studies have examined the relationships between this polymorphism and the risk of myocardial infarction, diffuse‐type gastric cancer susceptibility, and primary ovarian insufficiency . In addition, previous studies found that haplotypes of this polymorphism may affect the plasma level of PAI‐1 . Other research reported that the rs7242 polymorphism may affect blood insulin concentrations .…”

Justification of Genetic Factors for Predicting the Risk of Acute Bleeding in Peptic Ulcer Disease

“…To be able to do this, a standard genomic DNA was extracted from the blood of the probands, using a set of reagents to isolate DNA from the clinical material (“DNA-Sorb B”). The PCR amplification of the corresponding section of the PAI gene was performed using a specific pair of primers 5’ - CAC AGA GAG AGT CTG GCC ACG -3’ and 5’ - CCA ACA GAG GAC TCT TGG TC -3’, according to Jeon et al [ 21 ]. The amount of DNA for PCR was 50 ng per reaction.…”

Поліморфізм 5g4 Гена Інгібітору Активатора Плазміногена 1 (Pai-1) У Хворих На Гострі Ускладнення Виразкової Хвороби

“…ПЛР-ампліфікацію відповідної ділянки гена PAI здійснювали з використанням специфічної пари праймерів 5'-CAC AGA GAG AGT CTG GCC ACG -3' та 5'-CCA ACA GAG GAC TCT TGG TC -3', які відомі з літератури [15]. Кількість ДНК для проведення ПЛР становила 50 нг на реакцію.…”

“…Серед хворих із кровотечею найрідше виявлений гомозиготний генотип 4G/4G (n=6, 13,95% Без рецидиву кровотечі n=29 31,03 917,24 (5) р 1-9=0,04 χ 2 =5,14 51,72 (15) підгрупах здебільше була статистично істотно меншою, ніж у хворих без кровотечі. Попри це у хворих з кровотечами загалом статистично істотно частіше, ніж у хворих без кровотечі, траплявся гетерозиготний генотип 4G/5G.…”