Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population

Singh, HariOm; Sachan, Rekha; Devi, Sivanesan Saravana; Pandey, Sachchida Nand; Mittal, Balraj

doi:10.1016/j.ajog.2007.09.046

Cited by 37 publications

(36 citation statements)

References 29 publications

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“…[38][39][40][41] In a multivariate logistic analysis, we have evidenced that the GSTT1/GSTM1*0 ([ ]/ [-]) combined genotype provides a greater susceptibility for the development of spinocellular carcinoma of head and neck, similar results to those found by other authors. 7,23,42,43 Various studies could not correlate the null GSTT1 genotype with the head and neck cancer, 26,27,43 which was a result found in our study. Similarly, there was no association between this type of neoplasia and the null combined genotypes null GSTT1 and null GSTM1, as observed by Singh et al 7 On the other hand, a Chinese study has shown a correlation between the double null genotype GSTT1 and GSTM1 with nasopharynx cancer among men.…”

Section: Discussionsupporting

confidence: 68%

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme¹,

Raposo²,

Ruiz³

et al. 2010

Rev. Assoc. Med. Bras.

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Objective. To establish the clinical and demographic profile and identify risk factors among patients with head and neck cancer, relating them to the polymorphism of GSTT1 and GSTM1. MethOds. One hundred patients with head and neck cancer and 100 control group individuals without history of neoplasm were analyzed. The molecular analysis was made by multiplex polymerase chain reaction. For statistical analysis, data were tabulated and compared by the Fisher's exact test, the Chi-square test and multiple logistic regression were also used.Results. There was prevalence of smokers (OR = 5.32, CI 95% CI = 2.04-13.86 p = 0.0006), alcohol drinkers (OR = 5.04, CI 95% = 2.19-11.59 p = 0.0001) in head and neck cancer patients. The GSTT1 null genotype was found in 47% of the patient and 41% of the control group (OR = 0.67; CI 95%= 0.34-1.35; p = 0.2648). Likewise, the GSTM1 null genotype was found in 66% of the patient and 75% of the control group (OR = 2.25; CI 95%= 1.05 -4.84; p = 0.0368). The combined GSTT1 and GSTM1 gene null genotype shown association between GSTM1*0/GSTT1 and occurrence of head and neck carcinoma (OR = 7.64; CI 95%= 1.72-34.04; p = 0.0076). Analysis of clinical-pathological features showed association between GSTT1 null genotype and larynx, the inverse relation between this genotype and pharynx. cOnclusiOn. In our study it was possible to establish an association between the nullity of GSTM1 genotype and that of combined GSTT1/GSTM1*O ([]/ [-] genotypes and head and neck cancer. gstM1 and gstt1 genes analysis in head and neck canceR patients cássia veRidiana dOuRadO leMe 1 , luis séRgiO RapOsO 2 , MaRiangela tORReglOsa Ruiz 3 , jOice MatOs biselli 4 , ana lívia silva galbiatti 5 , jOsé victOR Maniglia 6 , éRika cRistina pavaRinO-beRtelli 7 , eny MaRia gOlOni-beRtOllO 8*

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Section: Discussionsupporting

confidence: 68%

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme¹,

Raposo²,

Ruiz³

et al. 2010

Rev. Assoc. Med. Bras.

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“…The GSTM1 subfamily mainly metabolizes polyaromatic hydrocarbons and the benzo-α-pyrene class of carcinogens, whereas GSTT1 is known to metabolize carcinogens like monohaloethanes and ethylene oxide [29]. In our meta-analysis, in Asians, the null genotype of GSTM1 was found to be associated with an increased CC risk, but the null genotype of GSTT1 was not.…”

Section: Discussionmentioning

confidence: 67%

“…According to the exclusion criteria, 15 articles were excluded including 5 articles containing overlapping population [7][8][9][10][11], 8 precancerous lesions included in the cases [12][13][14][15][16][17][18][19], 2 without sufficient data [20][21]. At last, data were available from 16 individual case-control studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Table 1 presented characteristics of these 16 case-control studies (a total of 1,627 CC cases and 2,161 controls). 14 studies on GSTM1 polymorphism (a total of 1,514 CC cases and 1,907 controls), 12 studies on GSTT1 polymorphism (a total of 1,187 CC cases and 1,590 controls), and 6 studies on GSTM1-GSTT1 interaction analysis (a total of 791 CC cases and 767controls) were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

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There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

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“…however, the results are inconsistent [6][7][8] . Although there were meta-analyses reported regarding the two gene polymorphisms and cervical cancer, these were not in the context of HPV infection.…”

Section: It Is Well Known That Human Papilloma Virus (Hpv)mentioning

confidence: 87%

“…21 studies of GSTM1 polymorphisms (2,250 CC cases and 3,025 controls) [6,8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] , 17 studies of GSTT1 polymorphisms (1,704 CC cases and 2,060 controls) genotypes [6, 11-13, 15-17, 20-24, 26-30] , and 9 studies of GSTM1-GSTT1 interaction analyses (1,046 CC cases and 1,319 controls) [6,11,12,15,16,24,26,28] were included in our meta-analysis. The characteristics of the studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Liu¹,

Zeng²,

Ma³

et al. 2017

ijSciences

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Objective: To study the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer (CC) risk, and explore genetic-environmental interactions. Methods: After a systematic literature search, all relevant studies entailing the association between GST polymorphisms and CC were included. The pooled odds ratio (OR) was used for analysis of the results and corresponding 95% confidence intervals (CI) were estimated. Results: A total of 23 case-control studies were included in the meta-analysis of GSTM1 (2,250 CC cases and 3,025 controls) and GSTT1 (1,704 CC cases and 2,460 controls) genotypes. For the GSTM1 polymorphisms, the null genotype of GSTM1 was associated with an increased CC risk for the total population (OR=1.57, 95% CI=1.25-1.98). A similar association was found in China (OR=2.34, 95% CI=1.56-3.52), India (OR=2.02, 95% CI=1.43-2.83), Pakistan (OR=5.52, 95% CI=2.34-13.07), Serbia (OR=1.73, 95% CI=0.68-4.39) and Kazakhstan (OR=6.5, 95%CI=2.25-18.81), but was not noted for others countries. Regarding human papilloma virus (HPV) infection, moderately but significantly increased risk of the null GSTM1 genotype was found in HPV-positive patients (OR=2.59, 95% CI=1.57-4.27). For the GSTT1 polymorphisms, the null GSTT1 genotype was associated with increased CC risk in the total population (OR=1.44, 95% CI=1.07-1.93). Regarding ethnic stratification, a significantly increased risk of the null GSTT1 genotype was found in Kazakhstan (OR=3.99, and Brazil (OR=4.58, 95% CI=2.04-10.28). With respect to smoking, the two aspects of the analysis above were not significantly associated with CC risk in smokers or non-smokers, respectively. For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk for the total population (OR=1.62, 95% CI=1.14-2.29). Conclusion: This meta-analysis provided sufficient evidence that the null genotype of GSTM1, or GSTT1 and the dual-null genotypes of GSTM1/GSTT1 are associated with CC.

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Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population

Cited by 37 publications

References 29 publications

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

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