Association of Helicobacter Pylori Infection and Colon Cancer

Strofilas, Alexandros; Lagoudianakis, Emmanuel; Seretis, Charalampos; Παππάς, Απόστολος; Koronakis, Nikolaos; Keramidaris, Dimitrios; Koukoutsis, Ilias; Chrysikos, Ioannis; Manouras, Ioannis; Manouras, Andreas

doi:10.4021/jocmr880w

Cited by 40 publications

(42 citation statements)

References 32 publications

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“…Laboratory studies have found that administration of VacA-positive strains of H. pylori (as well as CagA-positive H. pylori strains) induces an inflammatory response and increases gastrinemia (24, 25, 26), and that after H. pylori eradication, serum gastrin levels decrease significantly (27). An association between high gastrin levels and colorectal cancer risk has been suggested in several studies of human populations (28, 29, 30), although the association only reached significance in one (30). In the most recent study of the gastrin – colorectal cancer association, mean levels of gastrin did not differ between cases and controls, although significantly higher levels were seen among patients with lymph node metastasis compared to patients without ( P = 0.03) (29).…”

Section: Discussionmentioning

confidence: 97%

“…An association between high gastrin levels and colorectal cancer risk has been suggested in several studies of human populations (28, 29, 30), although the association only reached significance in one (30). In the most recent study of the gastrin – colorectal cancer association, mean levels of gastrin did not differ between cases and controls, although significantly higher levels were seen among patients with lymph node metastasis compared to patients without ( P = 0.03) (29). …”

Section: Discussionmentioning

confidence: 97%

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Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

Epplein

Pawlita

Michel

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background There is biological plausibility as to why infection with Helicobacter pylori, the leading cause of gastric cancer, may also increase the risk of colorectal cancer, but the epidemiological findings have been inconsistent. We assessed the association of H. pylori protein-specific infection and colorectal cancer risk in the prospective cohort, the Southern Community Cohort Study. Methods Multiplex serology was utilized to measure antibodies to 15 H. pylori proteins in pre-diagnostic blood among 188 incident colorectal cancer cases and 370 controls matched by age, race, sex, and blood collection timing. Conditional logistic regression was used to calculate ORs and 95% confidence intervals (CI). Results Overall H. pylori prevalence was not associated with colorectal cancer risk (OR, 1.03; 95% CI, 0.59–1.77). However, sero-positivity to any of five specific H. pylori proteins (VacA, HP231, HP305, NapA, HcpC) was associated with a significant 60 to 80% increase in odds of risk. These associations became even stronger when limited to colon cancer risk, particularly for the known H. pylori toxin VacA (OR, 2.24; 95% CI, 1.22–4.11), including a significant, positive dose-response association by VacA antibody levels in quartiles (P<0.05). Associations with VacA sero-positivity were especially strong for early onset and late stage cancers. Conclusions The findings raise the hypothesis that individuals with high levels of antibodies to specific H. pylori proteins may be at higher risk of colon cancer. Impact Further investigation of the H. pylori – colorectal cancer association is warranted to determine the possibility of protein-specific antibody levels as a risk biomarker.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

Epplein

Pawlita

Michel

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…However, in the current literature various frequencies of H. pylori infections have been reported in CC patients. Additionally, the prevalence of H. pylori infections in the tissue samples and the role of this infection in colorectal carcinogenesis were not yet well defined [21][22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…The mean duration of CIT was 13 days (range, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Of the 33 patients with CIT, 27 presented with various levels of chemotherapy-induced anaemia (CIA) and chemotherapy-induced neutropenia (CIN).…”

Section: Compliance With Treatmentmentioning

confidence: 99%

Association ofHelicobacter pyloriinfection with chemotherapy-induced thrombocytopenia in patients with stage III colon cancer: A pilot study

Tanrıverdi

2013

Platelets

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In this study, the effects of the pre-treatment presence of Helicobacter pylori (H. pylori) infection on chemotherapy-induced thrombocytopenia (CIT) were investigated in patients with stage III colon cancer (CC). A cohort of 74 patients with early stage CC was analysed through a review of clinical records and personal interviews. Helicobacter pylori infections were diagnosed in these patients prior to chemotherapy. The subjects were divided into two groups according to H. pylori infection status: Group 1, H. pylori-positive and Group 2, H. pylori-negative. In all patients, bone marrow toxicity and other study variables were compared. Helicobacter pylori infections were detected in 31 of the 74 CC patients. Helicobacter pylori-infected patients (Group 1) showed significantly higher incidences of CIT than did non-infected patients (Group 2; p = 0.029). Helicobacter pylori infection status correlated significantly with tumour location (r = 0.547; p = 0.043) and the most common location of CC in H. pylori-infected patients was the ascending colon (n = 13, 42%) in comparison to non-infected patients (n = 6, 14%; p= 0.042). The relationship between CIT and H. pylori infection status in CC was determined to be independent from the other study variables (p = 0.037; OR = 3.32, CI 95% = 1.16-9.70). In this study, the small number of patients resulted in an inadequate demonstration of the relationship between H. pylori infection and CIT. Therefore, clinical and molecular studies that include more patients are warranted.

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“…Three studies 41-42, 43 evaluated if a difference in the bacterium, CagA + H.pylori versus CagA - H. pylori, has any effect on CRC and associated lymph node metastasis. CagA + H. pylori have been reported to induce greater degree of inflammation than the CagA - strain, which leads to chronic atrophic gastritis.…”

Section: Helicobacter Pylorimentioning

confidence: 99%

Significance of Infectious Agents in Colorectal Cancer Development

Antonic¹,

Stojadinovic²,

Kester³

et al. 2013

J. Cancer

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Colorectal cancer (CRC) is a major burden to healthcare systems worldwide accounting for approximately one million of new cancer cases worldwide. Even though, CRC mortality has decreased over the last 20 years, it remains the third most common cause of cancer-related mortality, accounting for approximately 600,000 deaths in 2008 worldwide. A multitude of risk factors have been linked to CRC, including hereditary factors, environmental factors and inflammatory syndromes affecting the gastrointestinal tract. Recently, various pathogens were added to the growing list of risk factors for a number of common epithelial cancers, but despite the multitude of correlative studies, only suggestions remain about the possible relationship between selected viruses and bacteria of interest and the CRC risk. United States military service members are exposed to various risk factors impacting the incidence of cancer development. These exposures are often different from that of many sectors of the civilian population. Thereby, cancer risk identification, screening and early detection are imperative for both the military health care beneficiaries and the population as a whole. In this review, we will focus on several pathogens and their potential roles in development of CRC, highlighting the clinical trials evaluating this correlation and provide our personal opinion about the importance of risk reduction, health promotion and disease prevention for military health care beneficiaries.

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Association of Helicobacter Pylori Infection and Colon Cancer

Cited by 40 publications

References 32 publications

Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

Association ofHelicobacter pyloriinfection with chemotherapy-induced thrombocytopenia in patients with stage III colon cancer: A pilot study

Significance of Infectious Agents in Colorectal Cancer Development

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