2013
DOI: 10.1016/j.gene.2013.08.069
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Association of HHIP polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population

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Cited by 33 publications
(30 citation statements)
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“…Since Wnt2+ and Gli1+ cells persist in the adult lung, an important question is whether these cells play a role in regeneration after injury. Gli1 is a down-stream effector of hedgehog signaling and components of this pathway have been associated in GWAS studies with chronic obstructive pulmonary disease (COPD)(Pillai et al, 2009; Wang et al, 2013a; Wilk et al, 2009). Therefore, the hedgehog pathway and Gli1+ cells may play a role in adult lung homeostasis and injury response by controlling mesodermal expansion.…”
Section: Stem/progenitor Populations In Lung Developmentmentioning
confidence: 99%
“…Since Wnt2+ and Gli1+ cells persist in the adult lung, an important question is whether these cells play a role in regeneration after injury. Gli1 is a down-stream effector of hedgehog signaling and components of this pathway have been associated in GWAS studies with chronic obstructive pulmonary disease (COPD)(Pillai et al, 2009; Wang et al, 2013a; Wilk et al, 2009). Therefore, the hedgehog pathway and Gli1+ cells may play a role in adult lung homeostasis and injury response by controlling mesodermal expansion.…”
Section: Stem/progenitor Populations In Lung Developmentmentioning
confidence: 99%
“…(4,5) Although these loci were identified in GWAS conducted in populations of European and African descent, variants in these genes have also been implicated in COPD risk in Asians. (6)(7)(8) To date, there has been no GWAS of COPD conducted exclusively in Hispanic populations. (9) One recent study that did include a diverse group of Hispanics, along with members of other ethnic groups, identified a novel variant in MAN2B1 in Hispanics that was associated with lower values of the percentage of emphysema-like lung on computed tomography and higher plasma levels of alpha1 antitrypsin.…”
mentioning
confidence: 99%
“…According to a study by Zhou et al 8, rs13118928 contributed to the risk of severe COPD in smokers in a Polish population. In another study, rs13118928 was not associated with COPD in the Chinese, but rs12504628 was associated with FEV 1 /FVC, while rs10519717 of HHIP affected the severity of the disease38.…”
Section: Discussionmentioning
confidence: 93%