Association of Human Adenovirus-36 With Dyslipidemia in Tehranian Children and Adolescent; TLGS

Zarkesh, Maryam; Daneshpour, Maryam Sadat; Ehsandar, Shohreh; Bandehpour, Mojgan; AlFadhli, Suad; Azizi, Fereidoun; Hedayati, Mehdi

doi:10.5812/scimetr.23927

Cited by 1 publication

(2 citation statements)

References 26 publications

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“…These are 20 to 30 nucleotides-long noncoding RNAs which bind to 3′-UTR of the target primary transcript causing its destabilization and repression of translation. 81 89 Several miRNAs have been associated with T2DM susceptibility, like miR-375, miR-146a, and others, which were overexpressed in T2DM patients. 89 Apart from imparting susceptibility, some miRNAs have also been shown to be involved in action few antidiabetic drugs.…”

Section: Role Of Epigeneticsmentioning

confidence: 99%

“…81 89 Several miRNAs have been associated with T2DM susceptibility, like miR-375, miR-146a, and others, which were overexpressed in T2DM patients. 89 Apart from imparting susceptibility, some miRNAs have also been shown to be involved in action few antidiabetic drugs. One example of this is DPP-4 inhibitor linagliptin which alleviates kidney fibrosis by reversing the DDP-4-induced repression of miRNA29s.…”

Section: Role Of Epigeneticsmentioning

confidence: 99%

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Determinants in Tailoring Antidiabetic Therapies: A Personalized Approach

Rizvi¹,

Al-Abbas²,

Verma³

et al. 2022

Glob Med Genet

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Diabetes has become a pandemic as the number of diabetic people continues to rise globally. Being a heterogeneous disease, it has different manifestations and associated complications in different individuals like diabetic nephropathy, neuropathy, retinopathy, and others. With the advent of science and technology, this era desperately requires increasing the pace of embracing precision medicine and tailoring of drug treatment based on the genetic composition of individuals. It has been previously established that response to antidiabetic drugs, like biguanides, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and others, depending on variations in their transporter genes, metabolizing genes, genes involved in their action, etc. Responsiveness of these drugs also relies on epigenetic factors, including histone modifications, miRNAs, and DNA methylation, as well as environmental factors and the lifestyle of an individual. For precision medicine to make its way into clinical procedures and come into execution, all these factors must be reckoned with. This review provides an insight into several factors oscillating around the idea of precision medicine in type-2 diabetes mellitus.

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Section: Role Of Epigeneticsmentioning

confidence: 99%