Association of Human Leukocyte Antigen Haplotypes With End-Stage Renal Disease in Vietnamese Patients Prior to First Transplantation

Hieu, Ho Trung; Hà, Nguyễn Thu; Song, Lê Hữu; Nghi, Tran Hong

doi:10.1016/j.transproceed.2019.03.067

Cited by 8 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HLA typing of ESRD patients in our study is similar to research conducted by Hieu et al [12] on Northern Vietnamese ESRD patients and the general Vietnamese Kinh population reported by Do et al [13] The most common alleles in each locus (HLA-A*11, B*15, DRB1*12, DQA1*01, and DQB1*03) are also consistent with typing results from research conducted on East [14][15][16] and South-east Asian populations. [17,18] These findings are different from the most common alleles found in ESRD patients living in countries outside of the regions.…”

Section: Discussionsupporting

confidence: 91%

HLA types and their association with end-stage renal disease in Vietnamese patients: A cross-sectional study

et al. 2022

View full text Add to dashboard Cite

End-stage renal disease (ESRD) is a significant public health issue with an estimated increasing burden over the next 10 years. Early prediction of patients with a high risk of ESRD progression is crucial to monitor and initiate appropriate interventions, of which HLA alleles have been proposed as promising biomarkers. This cross-sectional study described HLA profiles of a Vietnamese cohort and investigated the association between HLA alleles and ESRD. All ESRD patients who were waitlisted to receive kidney transplant and potential donors in a tertiary hospital from March 2018 to April 2020 were invited to participate in the study. A total of 458 participants were eligible, including 126 ESRD patients and 126 family-related donors, 98 ESRD patients and 108 unrelated donors. HLA typing was performed using Luminex-based PCR-SSO technology. We found HLA-A*02, A*11, A*24, B*15, B*07, DRB1*12, DRB1*09, DQA1*01, DQA1*06, DQB1*03 and DQB1*05 as the most common alleles, which is similar to the general Vietnamese population and other countries in East and South-east Asia. HLA-B*07 (P = .040), DQA1*06 (P = .031), and DQB1*03 (P = .036) were susceptible to ESRD, while HLA-B*27 (P = .024) and DQB1*02 (P = .006) were associated with a decreased risk of ESRD.

show abstract

Section: Discussionsupporting

confidence: 91%

HLA types and their association with end-stage renal disease in Vietnamese patients: A cross-sectional study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For HLA-B locus, multiple alleles showed significant associations with ESRD. HLA-B � 15 was found to be positively associated with ESRD by four different works [12,14,17,18]. HLA-B � 55 [14,19] and HLA-B � 53 [13,20] were observed to be positively associated with ESRD in two studies.…”

Section: Discussionmentioning

confidence: 92%

“…S2 Table shows the HLA allele types that have shown significant associations (negative or positive) with ESRD in our work or previous studies. For HLA-A locus, the HLA-A � 11 allele showed a significant positive association with ESRD in three separate studies-that included study-participants from different populations [12][13][14]. In contrast, HLA-A � 28 showed a significant negative association with ESRD in two of the previous works [15,16].…”

Section: Discussionmentioning

confidence: 96%

Revisiting the association between human leukocyte antigen and end-stage renal disease

et al. 2020

View full text Add to dashboard Cite

Multiple works have studied possible associations between human leukocyte antigen (HLA) alleles and end stage renal disease (ESRD) showing, however, contradictory and inconsistent results. Here, we revisit the association between ESRD and HLA antigens, comparing HLA polymorphism (at HLA-A,-B,-C,-DRB1,-DQB1 and DQA1 loci) in ESRD patients (n = 497) and controls (n = 672). Our data identified several HLA alleles that displayed a significant positive or negative association with ESRD. We also determined whether heterozygosity or homozygosity of the ESRD-associated HLA alleles at different loci could modify the prevalence of the disease. Few HLA allele combinations displayed significant associations with ESRD, among which A*3_26 combination showed the highest strength of association (OR = 4.488, P� 0.05) with ESRD. Interestingly, the age of ESRD onset was not affected by HLA allele combinations at different loci. We also performed an extensive literature analysis to determine whether the association of HLA to ESRD can be similar across different ethnic groups. Our analysis showed that at least certain HLA alleles, HLA-A*11, HLA-DRB1*11, and HLA-DRB1*4, display a significant association with ESRD in different ethnic groups. The findings of our study will help in determining possible protective or susceptible roles of various HLA alleles in ESRD.

show abstract

“…For instance, HLA‐DRB1*03, HLA‐DRB1*04, HLA‐DRB1*11 and DQB1*02 were linked to the CRI risk in China, 25 whereas DRB1*14 was observed more frequently in patients from Vietnam. 26 …”

Section: Discussionmentioning

confidence: 99%

“…Some of the HLA-DRB1 alleles were significantly different in patients with CRI compared with the controls in certain studies. For instance, HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*11 and DQB1*02 were linked to the CRI risk in China,25 whereas DRB1*14 was observed more frequently in patients from Vietnam 26. The identified HLA alleles might be identified as potential haplotypes of allele groups inherited in patients with CRI.For example, C*12 and C*15 were related to certain common haplotypes within Romanian patients with CRI: A*01-C*15 and A*02-C*12.…”

mentioning

confidence: 99%

Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation

Mărunţelu

Cristea

Omer

et al. 2021

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Association of Human Leukocyte Antigen Haplotypes With End-Stage Renal Disease in Vietnamese Patients Prior to First Transplantation

Cited by 8 publications

References 11 publications

HLA types and their association with end-stage renal disease in Vietnamese patients: A cross-sectional study

HLA types and their association with end-stage renal disease in Vietnamese patients: A cross-sectional study

Revisiting the association between human leukocyte antigen and end-stage renal disease

Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation

Contact Info

Product

Resources

About