Association of IL-10 and IL-6 Gene Polymorphisms with Type 2 Diabetes Mellitus among Egyptian Patients

Abstract

Recent findings indicate that certain cytokines are capable of interfering with insulin sensitive glucose uptake and induce insulin resistance. To test for the association of IL-10-1082 and IL-6-174 Key words: IL-10, IL-6, gene polymorphism, type 2 diabetes, Egypt Mısır'lı Hastalarda Tip 2 Diyabet ile IL-10 ve IL-6 Gen Poliformizmi Arasındaki İlişki ÖZET Son yıllarda bazı sitokinlerin insülin duyarlı glikoz alınımı ile ilişkiye girebilme ile birlikte insülin direnci meydana

African vs. Caucasian and Asian difference for the association of interleukin-10 promotor polymorphisms with type 2 diabetes mellitus (a meta-analysis study)

“…Among these, five studies were performed among Europeans ( Tsiavou, A, et al, 2004 , Babel, N, et al, 2006 , Scarpelli, D, et al, 2006 , Forte, GI, et al, 2010 , Erdogan, M, et al, 2012 ), three studies were performed among Asians ( Kolla, VK, et al, 2009 , Kung, WJ, et al, 2010 and Bai et al, 2014 ), two studies were performed among Africans ( Mtiraoui et al, 2009 and Helaly and Hatata, 2013 ), and one among Mexicans ( García-Elorriaga et al, 2013 ). The overall frequencies of IL-10 − 1082 A > G gene polymorphism in control subjects was consistent with Hardy–Weinberg equilibrium (HWE) in spite of the presence of 5 non-consistent studies ( Bai, H, et al, 2014 , Helaly, MA and Hatata, EZ, 2013 , Kung, WJ, et al, 2010 , Kolla, VK, et al, 2009 , Babel, N, et al, 2006 ). The results of Eggers test suggested no publication bias for all comparisons ( Fig.…”

“…T2DM is a complex heterogeneous status of metabolic disorders including hyperglycemia and impaired insulin function and secretion ( Kramer et al, 2015 ). Several reports have demonstrated the association between IL-10 − 592 C > A , − 1082 A > G and − 819 C > T gene polymorphisms and the susceptibility of T2DM with relatively inconclusive conclusions ( Bai, H, et al, 2014 , Arababadi, MK, et al, 2012 , Scarpelli, D, et al, 2006 , Zhang, F, et al, 2013 , Helaly, MA and Hatata, EZ, 2013 , Erdogan, M, et al, 2012 , Mtiraoui, N, et al, 2009 , Chang, YH, et al, 2005 and Li et al, 2013 ). Knowing that the meta-analysis is a suitable method for evaluating small effects in human genetic association studies, we have designed this study to investigate and update the results recently given for the association of IL-10 − 592 C > A , − 1082 A > G and − 819 C > T gene polymorphisms with T2DM susceptibility in different ethnic subjects.…”

“…Although several studies and few meta-analyses have evaluated the association between IL-10 gene polymorphisms with the risk of development of T2DM in different ethnic populations, their results showed controversies and inconsistencies that might be due relatively small sample size, selection bias and ethnic difference ( Bai, H, et al, 2014 , Helaly, MA and Hatata, EZ, 2013 , Kung, WJ, et al, 2010 , Yin, YW, et al, 2012 , Li, J, et al, 2013 , Zhang, F, et al, 2013 , Mtiraoui, N, et al, 2009 ). Another issue of concern is the under-representation of African-based studies.…”

The cytokine gene polymorphisms (TNF- and #945;, IL-10 And IFN- and #947;) and the role of inflammatory cytokines in diabetic neuropathy

“…40 Studies conducted in France and Spain did not confirm any significant association of DM with different genotypes of IL-10 promoter polymorphisms in Caucasians. [43][44][45] Whereas few reports from Taiwanese, 46 Turkish 47 and Egyptian subjects 48 has shown association of IL-10-1082 homozygous GG with DM cases.…”

Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies

“…Also −1082A/G polymorphism of IL-10 seems to be a risk factor for T2DM in Asians but not in Europeans and Africans [ 116 ]. In another study it was reported that −1082GG genotype of IL-10 and −174CC genotype of IL-6 are as risk factors for T2DM in Egyptians [ 117 ]. In our study IL-4 has been studied but no significant association with T2DM was seen [ 66 ].…”