Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population

Kaur, Naindeep; Singh, Jagtar; Reddy, Srinivas Gosla

doi:10.1007/s10528-018-9880-7

Cited by 11 publications

(7 citation statements)

References 46 publications

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“…The CXCL8 gene polymorphisms have been related to susceptibility to chronic and inflammatory conditions involving eastern and western populations (Cui et al, 2016;Bishu et al, 2018). The rs4073 is one of the most analyzed SNPs regarding periodontal disease susceptibility, reporting associations with inflammatory conditions Kaur et al, 2019), although this has not been found in the present study.…”

Section: Discussioncontrasting

confidence: 66%

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Manso¹,

Hannum²,

Fortes³

et al. 2020

Genet. Mol. Res.

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©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 19 (3): gmr18568 J.A.X. Manso et al. 2 periogram, previously elaborated, together with a questionnaire concerning habits and life style. The DNA of the samples was genotyped using PCR-RFLP and qPCR, for each molecular marker. A significant trend to develop CPD was detected for individuals who brush their teeth less than twice a day. The allele of minor frequency of the variants rs1143634, rs1800796, and rs2227539 were associated with CPD, revealing a significant predictive effect (P < 0.05). The most significant findings involved the T (rs1143634) and C (rs1800796) alleles, which were associated with increased risk, when examined individually and together. We concluded that this is a multifactorial disease, although the genetic influence was predominant.

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Section: Discussioncontrasting

confidence: 66%

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Manso¹,

Hannum²,

Fortes³

et al. 2020

Genet. Mol. Res.

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“…As shown in Table 2 , the genotype distribution in controls is not in HWE in 3 of the included studies [ 16 , 20 , 21 ], this may influence the reliability of the study results. So to overcome this shortcoming, we recalculated the pooled ORs by excluding these 3 studies, and found that a significant association was still present in all dominant (OR 1.35, 95% CI 1.08–1.70, P =0.01), recessive (OR 1.32, 95% CI 1.07–1.63, P =0.01), allelic (OR 1.26, 95% CI 1.07–1.48, P =0.007), homozygote (OR 1.54, 95% CI 1.11–2.14, P =0.01), and heterozygote (OR 1.27, 95% CI 1.04–1.55, P =0.02) models of the IL-8 gene −251 A/T polymorphism.…”

Section: Resultsmentioning

confidence: 99%

“…Vogiatzi et al first reported that IL-8 gene −251 A/T polymorphism was associated with susceptibility to restenosis after PCI [ 12 ]. Thereafter, several other studies found that IL-8 gene −251 A/T polymorphism was associated with susceptibility of CAD, and that the −251 A allele may increase CAD risk [ 13 – 16 ]. However, other studies reported no significant correlation between the IL-8 gene −251 A/T polymorphism and the risk of CAD [ 17 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-8 Gene –251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis

2019

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BackgroundInflammation plays an important role in the pathogenesis of coronary artery disease (CAD). Studies have reported that inflammatory cytokine interleukin-8 (IL-8) gene −251 A/T (rs4073) polymorphism is correlated with CAD susceptibility, but the result remains controversial. The objective of this study was to clarify the association between IL-8 gene −251 A/T polymorphism and CAD risk.Material/MethodsA meta-analysis included 8244 patients from 9 individual studies with 10 populations was conducted. Heterogeneity test was conducted, and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated used fixed-effect or random-effects model accordingly. Publication bias was evaluated with the Begg’s funnel plot and Egger’s test. Sensitivity analysis was also conducted.ResultsA significant association between IL-8 gene −251 A/T polymorphism and CAD risk was found in the dominant model (OR 1.42, 95% CI 1.16–1.76, P<0.001), recessive model (OR 1.30, 95% CI 1.12–1.52, P<0.001), allelic model (OR 1.28, 95% CI 1.12–1.47, P<0.001), homozygote model (OR 1.59, 95% CI 1.21–2.08, P<0.001), and heterozygote model (OR 1.35, 95% CI 1.11–1.64, P=0.002). Subgroup analysis by ethnicity found significant associations in the Chinese population in the dominant model(OR 1.43, 95% CI 1.26–1.61, P<0.001), recessive model (OR 1.39, 95% CI 1.21–1.59, P<0.001), allelic model (OR 1.31, 95% CI 1.21–1.42, P<0.001), homozygote model (OR 1.66, 95% CI 1.41–1.95, P<0.001), and heterozygote model (OR 1.34, 95% CI 1.18–1.52, P<0.001), but no significant association was found in the Caucasian population. No significant publication bias was found.ConclusionsThe IL-8 gene −251 A/T polymorphism was significantly associated with CAD risk in the Chinese population but not in the Caucasian population, −251 A allele carrier had an increased risk of CAD in the Chinese population.

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“…[17] Common genetic SNPs in asthma-related genes play a significant role in disease progression. Promoter region SNP IL-8 rs4073 A/T (-251A/T) has been connected to the regulation of transcriptional activity of the IL-8 gene and the levels of IL-8 production [18][19][20].…”

Section: Journal Of Applied Sciences and Nanotechnologymentioning

confidence: 99%

Primer and Probe Designing to Detect SNP rs 4073 in Interleukin-8 Gene in Iraqi Patients with Bronchial Asthma

Jan¹,

Alsaadi²,

Al-Khafaji³

et al. 2021

JASN

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Asthma is one of the most prevalent non-communicable illnesses, and it has a significant influence on the quality of life for many people. Asthma is now thought to be a multifaceted condition, with interactions between genetic susceptibility, host factors, and environmental exposures increasingly being blamed for its pathogenesis. In respiratory illness, interleukin-8 plays a critical function due to promoting phagocytosis and inducing angiogenesis. Also, identification and finding out the effect of these SNPs and how it can be dangerously related or contribute to a Bronchial Asthma disease. However, the available methods for detecting interleukin-8 gene polymorphism are direct and quantitative using Poly Chain Reaction (RT-PCR) in real time. Whole blood was isolated from 100 patients with asthma and 50 healthy individuals. The results of polymorphism in single nucleotides showed an essential role in the development of asthma and that the presence of these SNPs has a role in increasing the susceptibility of individuals to asthma, as the variation in the TT genotype at the site followed by the AT genotype at the same site shows high-risk damage.

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Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population

Cited by 11 publications

References 46 publications

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Interleukin-8 Gene –251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis

Primer and Probe Designing to Detect SNP rs 4073 in Interleukin-8 Gene in Iraqi Patients with Bronchial Asthma

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