Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy

Abstract

Diabetes and diabetic nephropathy are complex diseases affected by genetic and environmental factors. Identification of the susceptibility genes and investigation of their roles may provide useful information for better understanding of the pathogenesis and for developing novel therapeutic approaches. Intercellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein expressed on endothelial cells and leukocytes in the immune system. The ICAM1 gene is located on chromosome 19p13 within the linkage region of diabetes. In the recent years, accumulating reports have implicated that genetic polymorphisms in the ICAM1 gene are associated with diabetes and diabetic nephropathy. Serum ICAM1 levels in diabetes patients and the icam1 gene expression in kidney tissues of diabetic animals are increased compared to the controls. Therefore, ICAM1 may play a role in the development of diabetes and diabetic nephropathy. In this review, we present genomic structure, variation, and regulation of the ICAM1 gene, summarized genetic and biological studies of this gene in diabetes and diabetic nephropathy and discussed about the potential application using ICAM1 as a biomarker and target for prediction and treatment of diabetes and diabetic nephropathy.

Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes

“…It is noteworthy that Nox-4 is essential to insulin signal propagation (17) and cardiac remodeling (16,18). Interestingly, Nox-4 signaling links to ICAM-1, which is an inflammatory mediator that also increases in T2DM (9) and selectively decreased by Ex-4 (Fig. 5, G and H) (27), suggesting that the essential effects of Ex-4 may be mediated by ICAM-1/Nox-4 axis.…”

A case of “hidden” diabetic nephropathy diagnosed by a combination of renal biopsy findings and continuous glucose monitoring system

“…Previous reports, however, suggest that diabetes mellitus, hypertension and smoking contribute to kidney disorders via some common pathways. Diabetes mellitus, including postprandial hyperglycemia, and smoking, may cause damage to the glomeruli by common pathways, for example, that of AGEs [4,10,12], dysregulation of intracellular adhesion molecule (ICAM)-1 expressed by vascular endothelial cells [13][14][15][16] and increasing the expression of transforming growth factor beta (TGF-b), an profibrotic cytokine [17,18]. It is difficult to distinguish diabetic nephropathy from ING except by speculation based on the clinical course.…”

The predictive value of serum intercellular adhesion molecule 1 for the progression of diabetic kidney disease in type 2 diabetic patients

“…In diabetic milieu and upon cytokine stimulation, ICAM 1 gene expression on the surface of endothelium cells is up-regulated. ICAM 1 protein binding activity with LFA-1 is increased and more lymphocytes from blood are transferred into glomeruli and interstitium (9), triggering in-404 Values are presented as mean ± SD for normally distributed variables and median (25 th -75 th percentiles) for the abnormally distributes ones.…”