Association of Interleukin 10 Haplotype with Low Bone Mineral Density in Korean Postmenopausal Women

Abstract

Osteoporosis is a disease characterized by exaggerated loss of bone mass, with as much as 50 to 85% of the variation in bone mineral density (BMD) commonly accepted as being genetically determined. Although intensive studies have attempted to elucidate the genetic effects of polymorphisms on BMD and/or osteoporosis in several genes, the genes involved are still largely unknown. The possible associations of genetic variants in five-candidate genes (IL10, CCR3, MCP1, MCP2 and GC) with spinal BMD were investigated in Korean postmenopausal women (n = 370). Fourteen SNPs in five candidate genes were genotyped, and the haplotypes of each gene constructed. The associations of adjusted spinal BMD by age, year since menopause (YSM) and body mass index (BMI), with genetic polymorphisms, were analyzed using multiple regression models. Genetic association analysis of Korean postmenopausal women revealed that IL10 -592A > C and/or IL10 ht2 were associated with decreased bone mass, whereas no significant associations were observed with all polymorphisms in other genes. The levels of spinal BMD in individuals bearing the IL10 -592CC genotype were lower (0.78 ± 0.16) than those in others (0.85 ± 0.17) (P = 0.02), and the BMD of IL10 ht2 bearing individuals were also lower (0.82 ± 0.15) than those in others (0.85 ± 0.17) (P = 0.04). Our results suggest that variants of IL10 might play a role in the decreased BMD, although additional study might need to be followed-up in a more powerful cohort.

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

“…Previous studies observed the opposite with IL-10. Byung Lae Park et al [43] found some connection of IL-10 haplotype with the reduced BMD in Korean postmenopausal women accompanied by the reduction of BMD. But the relationship between IL-10 and BMD was still not explained completely.…”

Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases

“…Recent studies have indicated that the polymorphisms of IL-10 gene, which may affect IL-10 production, are associated with reduced bone mineral density (BMD) in postmenopausal women who were prone to suffered from osteoporosis [35, 36]. However, serum levels of IL-10 are significantly lower in the postmenopausal osteoporotic patient than in postmenopausal healthy women [37].…”

Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse

“…PTHR1 has been associated with BMD by Scillitani et al [33] who demonstrated that the subjects bearing at least one (AAAG)6 allele in the P3 promoter of PTHR1 gene have a higher femoral neck (FN) BMD than those without, suggesting the variation in promoter activity of the PTHR1 gene may exert a relevant genetic influence on BMD. IL10 has been found to be associated with BMD by Park et al [16]. The investigators studied the possible associations of genetic variants in five-candidate genes with spinal BMD.…”