Association of killer cell immunoglobulin‐like receptors with spontaneous clearance of hepatitis C virus in the Chinese population

Shan, Zhengang; Huang, Jieting; Liao, Qiao; Huang, Ke; Wang, Min; Xu, Ru; Tang, Xi; Zhang, Weiyun; Nelson, Kenrad E.; Fu, Yongshui; Li, Chengyao; Xiao, Rong

doi:10.1111/trf.14527

Cited by 15 publications

(15 citation statements)

References 39 publications

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“…These findings are consistent with previous reports of KIR and HLA genotyping, indicating that the absence of HLA ligands for inhibitory KIRs could be associated with a significant reduction of CMV infection [11]. The cumulative evidence shows that KIR2DL2 –HLA-C1 and KIR2DL3 may be molecular biomarkers of virus-induced diseases [22,23,24].…”

Section: Discussionsupporting

confidence: 91%

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

Dęborska−Materkowska

Perkowska‐Ptasińska

Sadowska-Jakubowicz

et al. 2019

IJMS

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Infection with cytomegalovirus (CMV) remains a major problem in kidney transplant recipients, resulting in serious infectious complications and occasionally mortality. Accumulating evidence indicates that natural killer cell immunoglobulin-like receptors (KIRs) and their ligands affect the susceptibility to various diseases, including viral infections (e.g., CMV infection). We investigated whether KIR genes and their ligands affect the occurrence of CMV infection in a group of 138 kidney transplant recipients who were observed for 720 days posttransplantation. We typed the recipients for the presence of KIR genes (human leukocyte antigen C1 [HLA-C1], HLA-C2, HLA-A, HLA-B, and HLA-DR1) by polymerase chain reaction with sequence-specific primers. The multivariate analysis revealed that the lack of KIR2DS2 (p = 0.035), the presence of KIR2DL3 (p = 0.075), and the presence of KIR2DL2–HLA-C1 (p = 0.044) were risk factors for posttransplant CMV infection. We also found that a lower estimated glomerular filtration rate (p = 0.036), an earlier time of antiviral prophylaxis initiation (p = 0.025), lymphocytopenia (p = 0.012), and pretransplant serostatus (donor-positive/recipient-negative; p = 0.042) were independent risk factors for posttransplant CMV infection. In conclusion, our findings confirm that the KIR/HLA genotype plays a significant role in anti-CMV immunity and suggest the contribution of both environmental and genetic factors to the incidence of CMV infection after kidney transplantation.

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Section: Discussionsupporting

confidence: 91%

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

Dęborska−Materkowska

Perkowska‐Ptasińska

Sadowska-Jakubowicz

et al. 2019

IJMS

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“…As CF is accompanied by severe infectious lesions of the upper respiratory tract, the treatment of which is far from always effective, it cannot be ruled out, that the genetically induced weakness of the activating receptor site of natural killer cells is affecting this process. It should be noted, that we did not meet such studies in the literature, but based on literary data, which relate mainly to HIV infection [23][24][25] and hepatitis C [26][27][28][29][30], it can be concluded, that the more gentle progression of the disease correlates with increased activation of the functional activity of NK cells.…”

Section: Resultsmentioning

confidence: 89%

Spectrum and Frequency of Nk Cell Receptor Genes Among Cystic Fibrosis Patients

Zastavna

Sosnina

Terpyliak

et al. 2020

EUREKA: Life Sciences

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Aim – to establish and analyze the spectrum of KIR genes in people with a confirmed diagnosis of Cystic fibrosis (CF), homozygote of F508del mutation of the СFTR gene for understanding the genetic predisposition of congenital immunity key part functioning during CF. Materials and Methods. Examined 48 people with a confirmed diagnosis of CF, homozygotes of the F508del mutation of the CFTR gene, and 104 practically healthy people without the F508del mutation of the CFTR gene from the control group. The following molecular genetic methods were used: DNA extraction from peripheral blood cells, KIR genotyping by PCR-SSP for the presence or absence of the 14 KIR genes (KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1). Results – molecular genetic studies of KIR-genes repertoire in the group of cystic fibrosis patients showed a decrease in the frequency of genes, responsible for activating NK cells receptors. Of the five examined NK cell activation genes, one gene was completely absent, namely 2DS4, and another (2DS1) was detected in only 3 of 48 patients examined, which was 6.25 %, and this figure is significantly lower in comparison with the control group (c2=4.801, p<0.05). Regarding the genes of NK-cell inhibitory receptors, all investigated genes were detected in the study group (8 in general). By detection frequency, they mostly correspond to the control group, with the exception of the 2DL3 gene, found in patients with CF with a significantly lower frequency (c2=11.97, p<0.005). Conclusion – for the first time in the group of patients with CF, a study was performed on the frequency and spectrum of KIR-genes, responsible for NK cell receptors. Reducing the frequency of activation NK cell receptor genes in patients with CF can lead to a weakening of congenital immunity and the severity of infectious processes during CF

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“…KIR2DL5A is an inhibitory receptor of immune response [33] and it is involved in immune response to viral infection and prognosis of certain malignant diseases. Shan et al reported that patients with KIR2DL5A -/2DL5B + genotype had increased HCV clearance [34]. In colorectal cancer, the presence of KIR2DL5A is related to increased complete response rate in patients treated with FOLFIRI chemotherapy [35], and KIR2DL5A is also a protective factor against breast cancer [36], while in pediatric leukemia patients after hematopoietic stem cell transplantation, the presence of KIR2DL5A is associated with higher relapse rate [37].…”

Section: Database Analysismentioning

confidence: 99%

Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA)

et al. 2020

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Background: Many patients are not responsive or tolerant to medical therapies for carotid atherosclerosis. Thus, elucidating the molecular mechanism for the pathogenesis and progression of carotid atherosclerosis and identifying new potential molecular targets for medical therapies that can slow progression of carotid atherosclerosis and prevent ischemic events are quite important. Material/Methods: We downloaded the expression profiling data of PBMC in Biobank of Karolinska Endarterectomy (BiKE, GSE21545) for GEO. The WGCNA and DEG screening were conducted. The co-expression pattern between patients with ischemic events (the events group) and patients without ischemic events (the no-events group) were compared. Then, we identified hub genes of each module. Finally, the DEG co-expression network was constructed and MCODE was used to identify crucial genes based on this co-expression network. Results: In the study, 183 DEGs were screened and 8 and 6 modules were assessed in the events group and no-events group, respectively. Compared to the no-events group, genes associated with inflammation and immune response were clustered in the green-yellow module of the events group. The hub gene of the green-yellow module of the events group was KIR2DL5A. We obtained 1 DEG co-expression network, which has 16 nodes and 24 edges, and we detected 5 crucial genes: SIRT1, THRAP3, RBM43, PEX1, and KLHDC2. The upregulated genes (THRAP3 and RBM43) showed potential diagnostic and prognostic value for the occurrence of ischemic events. Conclusions: We detected 8 modules for the events group and 6 modules for the no-events group. The hub genes for modules and crucial genes of the DEG co-expression network were also identified. These genes might serve as potential targets for medical therapies and biomarkers for diagnosis and prognosis. Further experimental and biological studies are needed to elucidate the role of these crucial genes in the progression of carotid atherosclerosis.

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Association of killer cell immunoglobulin‐like receptors with spontaneous clearance of hepatitis C virus in the Chinese population

Cited by 15 publications

References 39 publications

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

Spectrum and Frequency of Nk Cell Receptor Genes Among Cystic Fibrosis Patients

Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA)

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