Association of Lipid Composition and Unsaturated Fatty Acids of VLDL with Atrial Remodeling in Metabolic Syndrome

Abstract

Background: Subjects with metabolic syndrome (MetS) commonly have atrial remodeling, which indicates a risk for atrial fibrillation. Objective: This study determined MetS-related changes in lipid components in very-low-density lipoprotein (VLDL), which has been shown causing atrial remodeling, and the effect of statins on these changes, and the correlation between atrial remodeling and VLDL lipid compositions. Methods: Blood samples were collected from 12 non-MetS and 27 sex- and age-matched MetS subjects. Fourteen patients with MetS (MetS­–off statin) discontinued statin therapy 14 days before the study, while the remaining 13 remained on it (MetS–on statin). The VLDLs were isolated and processed for mass-based lipid profiling. Lipidomic analyses were performed and associated with atrial remodeling markers measured using standard echocardiography and electrocardiography. Results: Compared with the VLDL components of the non-MetS group, glucosyl/galactosyl ceramide, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were enriched in the MetS–off statin group. The statin therapy attenuated all abnormally abundant lipid classes in MetS, except for triglycerides. In addition, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were significantly correlated with atrial dilatation, and the latter two were also correlated with the PR interval. Enrichment of double bonds, which indicates unsaturated fatty acids, was also significantly correlated with atrial remodeling, and P-wave duration. Conclusion: This study suggests that the pathological lipid payload of MetS-VLDL may contribute to atrial remodeling in patients.

Plasma triglyceride is associated with the recurrence of atrial fibrillation after radiofrequency catheter ablation: A retrospective study

“…23,24 In addition, a study suggests that the amount of unsaturated fatty acids in TGs is positively correlated with the expression of cardiac remodeling markers, including left atrial diameter, maximum volume, emptying volume, left ventricular ejection fraction, and LA contractile force. 25 These studies suggest that lipid metabolism may be involved in the occurrence of AF by altering the structure of the heart. Since the recurrence rate of AF remains high within 12 months of catheter ablation, 28,29 continued treatment and regular follow-up after surgery are required.…”

“…A recent large retrospective cohort study has shown that circulating Lp(a) level is inversely correlated with the risk of AF development 23,24 . In addition, a study suggests that the amount of unsaturated fatty acids in TGs is positively correlated with the expression of cardiac remodeling markers, including left atrial diameter, maximum volume, emptying volume, left ventricular ejection fraction, and LA contractile force 25 . These studies suggest that lipid metabolism may be involved in the occurrence of AF by altering the structure of the heart.…”

Ether-linked phosphatidylethanolamine is a chemo-desensitizer of human carcinomas and epithelial ovarian cancer cells

“…However, neutral lipids and phospholipids can also be imported via lipoproteins and their corresponding receptors. For example, Lee et al found that atrial remodeling is related to VLDL-mediated unsaturated fatty acid import, e.g., TAG and lysophosphatidylcholine (LPC) or LPE (47).…”