Association of longitudinal changes in serum lipids with the natural history of subclinical hypothyroidism: A retrospective cohort study using data from the REACTION study

Zhong, Fang; Guan, Qingbo; Zhang, Haiqing; Zhang, Xu; Zhao, Meng; Yuan, Zhongshang; Fan, Xiude; Han, Junming; Li, Qihang; Wang, Zhixiang; Shao, Shanshan; Zhao, Jiajun

doi:10.1016/j.eclinm.2022.101629

Cited by 3 publications

(3 citation statements)

References 31 publications

(48 reference statements)

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“…A recent study also took this different perspective and examined the relationship between the longitudinal lipid profile and progression of subclinical hypothyroidism using data from the REACTION study [ 22 , 25 ]. Patients with subclinical hypothyroidism had documentation of their lipid profile on two occasions three years apart and the lipid changes were classified as a greater than 25% increase, versus a minor change, versus a greater than 25% decrease.…”

Section: Lipid Changes With Subclinical Hypothyroidismmentioning

confidence: 99%

“…The investigators used logistic regression models to assess the association between the changes in the lipid parameters and the natural history of subclinical hypothyroidism, including age, sex, body mass index, TSH, free triiodothyronine, free thyroxine, thyroid peroxidase antibodies, creatinine, smoking status, and alcohol consumption in the model. The investigators found that increase in TC levels increased the risk of progression to overt hypothyroidism, while a decrease in TC and TG levels was associated with a higher likelihood of regression to euthyroidism [ 25 ]. These findings were seen in both a retrospective cohort and a validation cohort.…”

Section: Lipid Changes With Subclinical Hypothyroidismmentioning

confidence: 99%

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Hypothyroidism, lipids, and lipidomics

Jonklaas

2023

Endocrine

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Purpose Hypothyroidism is a relatively common endocrine disorder and is well documented to be associated with lipid abnormalities. Methods A narrative review was conducted of studies describing the alterations in the lipid profile accompanying both subclinical and overt hypothyroidism. Results Lipid abnormalities are seen with TSH values in the upper end of the accepted reference range, as well as with subclinical and overt hypothyroidism. The degree of lipid derangement is generally proportional to the degree of TSH elevation. Other factors such as age, sex, and body mass index can also influence the pattern of the lipid abnormalities seen. The most robust finding with TSH elevation is increases in the low density lipoprotein cholesterol. Thyroid hormone treatment is efficacious in reversing the lipid abnormalities in both subclinical and overt hypothyroidism. Conclusion Given the association of lipid abnormalities with metabolic and cardiovascular disease, consideration of hypothyroidism as an important non-communicable disease may facilitate studies that test the hypothesis that thyroid hormone treatment to reverse hypothyroidism-associated lipid abnormalities may improve metabolic and cardiovascular outcomes.

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Section: Lipid Changes With Subclinical Hypothyroidismmentioning

confidence: 99%

Section: Lipid Changes With Subclinical Hypothyroidismmentioning

confidence: 99%

Hypothyroidism, lipids, and lipidomics

Jonklaas

2023

Endocrine

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“…The REACTION study was a population-based multicenter study, in which a total of 259,657 Chinese adults (aged ≥40 years) from 25 communities across mainland China were recruited to participate in the baseline survey during 2011 to 2012. The detailed design and methods of the study cohort have been described previously (11)(12)(13). Briefly, eligible participants were identified from the local residence registration records and was approached by trained community workers using a door-to-door invitation in the baseline survey during 2011 to 2012.…”

Section: Study Populationmentioning

confidence: 99%

Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

Wu,

Wang,

Lin

et al. 2024

Front. Endocrinol.

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BackgroundThe triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.MethodsThis cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.ResultsMultivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19–2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13–17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09–1.68), 1.27 (1.05–1.54), 1.26 (1.05–1.52), and 1.32 (1.08–1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44–3.87).ConclusionThe TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.

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The change in thyroid function categories with time in patients with subclinical hypothyroidism: a systematic review and meta-analysis

Zhang,

Wang

et al. 2024

BMC Endocr Disord

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Background Subclinical hypothyroidism (SCH) is characterized by elevated levels of thyroid hormone (TSH) and normal levels of free thyroxine (FT4). The outcomes of SCH patients are crucial for determining treatment plans; therefore, our aim is to summarize the existing prospective studies to understand the changes in thyroid function over time in SCH patients and the factors influencing these changes, providing references for clinical diagnosis and treatment. Methods We searched PubMed, Embase, Cochrane Library, and Web of Science for prospective follow-up studies on natural outcomes of SCH published until September 2024. Results are presented as the overall risk ratio (RR) and 95% confidence intervals (CI). Results We reviewed 8 prospective follow-up studies involving 1,859 individuals and extracted data from them for a meta-analysis. We found that when TSH levels are ≥ 10 mU/L, patients with SCH are more likely to progress to overt hypothyroidism (OH) (RR11.38, 95%CI 4.98–26.03, P <0.001) and were less likely to return to normal TSH levels (RR 0.20, 95%CI 0.09–0.42, P <0.001) compared to patients with TSH between 4.5 and 9.9 mU/L. In addition, patients who test positive for thyroid peroxidase antibodies (TPOAb) are more likely to progress to OH (RR 2.53, 95% CI 1.86–3.44, P < 0.001) and less likely to return to euthyroidism (RR 0.68, 95% CI 0.60–0.76, P < 0.001) compared to TPOAb-negative patients. Conclusion The results indicated that a large proportion of patients diagnosed with SCH will return to normal TSH levels or maintain SCH. Additionally, patients with TSH levels ≥ 10 mU/L or positive for TPOAb are more likely to experience progression and should be closely monitored. However, we did not find any gender differences in the natural outcome of SCH. Supplementary Information The online version contains supplementary material available at 10.1186/s12902-024-01754-7.

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Association of longitudinal changes in serum lipids with the natural history of subclinical hypothyroidism: A retrospective cohort study using data from the REACTION study

Cited by 3 publications

References 31 publications

Hypothyroidism, lipids, and lipidomics

Hypothyroidism, lipids, and lipidomics

Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

The change in thyroid function categories with time in patients with subclinical hypothyroidism: a systematic review and meta-analysis

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