Association of maternal chronic disease with risk of congenital heart disease in offspring

Chou, Hsin Hsu; Chiou, Meng-Jiun; Liang, Fu-Wen; Chen, Lea Hua; Lu, Tsung Hsueh; Li, Chung‐Yi

doi:10.1503/cmaj.160061

Cited by 75 publications

(85 citation statements)

References 42 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, simple CHD includes VSD, atrial septal defect, congenital pulmonary valve stenosis, congenital stenosis of aortic valve, patent ductus arteriosus, coarctation of aorta, and stenosis of pulmonary artery. To avoid the enrollment of nonsignificant clinical forms or spontaneously resolved defects, only those children who had a CHD‐specific admission were recruited (Chou et al, ). Severe CHD in this study includes double outlet right ventricle, transposition of the great arteries, common ventricle, single ventricle, atrioventricular septal defect, TOF, congenital tricuspid stenosis, hypoplastic left heart syndrome, atresia of pulmonary artery, and total anomalous pulmonary venous return.…”

Section: Methodsmentioning

confidence: 99%

Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring

Zhao

Xia

et al. 2019

Birth Defects Research

View full text Add to dashboard Cite

Background: In general, the existing evidence points to a role for maternal sleep in pregnancy complications and fetal growth, however, little has been focused on birth defects. We aimed to explore the association between periconceptional poor sleep and the risk of congenital heart disease (CHD), and to examine if daytime napping could to some extent change the association. Methods: A case-control study was conducted in Shanghai Children's Medical Center, in which, a total of 524 cases (262 simple CHD vs. 262 severe CHD), along with 262 controls. Results: In the multivariable logistic analysis, poor sleep could increase the risk of both simple CHD (OR = 2.486, 95% CI = 1.619-3.818) and severe CHD (OR = 1.950, 95% CI = 1.269-2.997), while routine daytime nap could decrease risk of simple CHD (OR = 0.634, 95% CI = 0.435-0.923). In the stratified analysis, the concurrence with routine daytime nap could weaken the risk of simple CHD caused by poor sleep (OR = 3.183, 95% CI: 1.830-5.537 decreased to OR = 2.236, 95% CI: 1.200-4.165). The examinations were repeated in ventricular septal defect and tetralogy of Fallot, and the established associations can be verified. Moreover, all these findings were also similarly observed in both propensityscore-adjusted and propensity-score-matched analyses. Conclusions: Poor maternal sleep around periconceptional period seems to be an independent risk factor for CHD. The concurrence with daytime nap could to some extent reduce the risk in simple CHD. The results individually and collectively put forward the importance of maternal sleep in embryonic heart development. K E Y W O R D S case-control study, congenital heart disease, daytime nap, maternal sleep, pregnancy Anda Zhao and Kena Zhao contributed equally to this work.

show abstract

Section: Methodsmentioning

confidence: 99%

Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring

Zhao

Xia

et al. 2019

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…Despite increased congenital heart diseases in newborns of mothers with gestational diabetes, no congenital heart anomaly was detected in those referred to our clinic because of maternal gestational diabetes mellitus (9,10). This may be due to a small number of patients with gestational diabetes mellitus.…”

Section: Discussionmentioning

confidence: 71%

Fetal Echocardiography Characteristics in a Tertiary Center

Erolu¹

2020

Erciyes Med J

View full text Add to dashboard Cite

Objective: Fetal echocardiography is an important and growing diagnostic tool for early detection of congenital heart diseases and rhythm problems. In this study, we evaluated retrospectively indications and prenatal and postnatal diagnoses for fetal echocardiography. Materials and Methods: Prenatal and postnatal echocardiographic diagnoses of the newborns and data of pregnant women who were referred to the Pediatric Cardiology Clinic of Ümraniye Training and Research Hospital between October 2018 and October 2019 and newborns were obtained from medical recordings. Results: In this study, 138 patients were included. Eighty-one (58%) indication was suspected congenital heart disease, twenty-four indications (13%) was screening test positivity, 10 hyperechogenic focus, two advanced age pregnancy, six diabetes mellitus. Two were hydrops fetalis (immune/nonimmune), five dysrhythmias, one fetal anomaly. Hereditary causes were congenital heart disease in seven previous pregnancies. Sixty-eight patients with normal fetal echocardiography were normal in the postnatal period. Diagnosis of cyanotic congenital heart diseases was 24.2% of all patients, and 47.1% were acyanotic congenital heart disease in our study population. Four of the patients had arcus aorta anomalies. One patient had sustained supraventricular tachycardia with hydrops fetalis resolved with sotalol and digoxin treatment. One patient had neonatal thyrotoxicosis because of maternal graves disease Conclusion: Fetal echocardiography is a useful and noninvasive method for early diagnosis and treatment, especially in rhythm problems. Also, diagnosis of congenital heart diseases antenatally is useful for planning the management of the disease.

show abstract

“…A drug safety stratification list for AED structural teratogenicity is summarized in Table 2. [14][15][16][17][18] The Australian Pregnancy Registry compared AED medication for epilepsy and non-epilepsy use for the prevalence of congenital anomalies and reported an anomaly rate for epilepsy with AED use in the first trimester of 5%, rate for epilepsy with AED use in the second and third trimester of 4%, rate for epilepsy with no AED use of 2%, and rate for no epilepsy but using AEDs of 3%. 20 Educational outcomes for children born to epileptic mothers, following in utero exposure to AED polytherapy or valproate alone, were significantly decreased compared with "control" 7-year-old children.…”

Section: Prevention For Selected Maternal Comorbidities That Can Makementioning

confidence: 99%

Prevention = Pre-Conception Counselling

Wilson

2018

Journal of Obstetrics and Gynaecology Canada

View full text Add to dashboard Cite

Association of maternal chronic disease with risk of congenital heart disease in offspring

Abstract: Interpretation:The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent. AbstractResearch CMAJ, December 6, 2016, 188(17-18)

Cited by 75 publications

References 42 publications

Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring

Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring

Fetal Echocardiography Characteristics in a Tertiary Center

Prevention = Pre-Conception Counselling

Contact Info

Product

Resources

About