Association of Migraine and Ischemic Heart Disease: A Review

Saeed, Aisha; Rana, Kiran F; Warriach, Zain I; Tariq, Marium; Malik, Bilal Haider

doi:10.7759/cureus.5719

Cited by 6 publications

(5 citation statements)

References 33 publications

(55 reference statements)

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“…Numerous studies have also shown migraine to be an important risk factor for ischemic heart disease (IHD), as well as other adverse cardiac events, such as myocardial infarction, angina, and arrhythmia ( 110 , 111 ). Furthermore, research has also found an increased risk of patent foramen ovale, atrial septal defect, and mitral valve prolapse in migraine patients with aura ( 110 , 111 ).…”

Section: Biological Risk Factors and Comorbiditiesmentioning

confidence: 99%

Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities

et al. 2022

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Migraine affects more than one billion individuals each year across the world, and is one of the most common neurologic disorders, with a high prevalence and morbidity, especially among young adults and females. Migraine is associated with a wide range of comorbidities, which range from stress and sleep disturbances to suicide. The complex and largely unclear mechanisms of migraine development have resulted in the proposal of various social and biological risk factors, such as hormonal imbalances, genetic and epigenetic influences, as well as cardiovascular, neurological, and autoimmune diseases. This review presents a comprehensive review of the most up-to-date literature on the epidemiology, and risk factors, as well as highlighting the gaps in our knowledge.

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Section: Biological Risk Factors and Comorbiditiesmentioning

confidence: 99%

Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities

et al. 2022

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“…We considered baseline comorbidities of diabetes (ICD-9-CM250), hypertension (401–405), hyperlipidemia (272.0–272.4), arrhythmia (427), thyroid disease (240–246), and migraine (346) potential covariates associated with the development of IHD [ 2 , 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Risk of Ischemic Heart Disease Associated with Primary Dysmenorrhea: A Population-Based Retrospective Cohort Study

Yeh

Muo

Sung

et al. 2022

JPM

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The awareness on ischemic heart disease (IHD) in women with dysmenorrhea is insufficient. We utilized the National Health Insurance Research Database (NHIRD) of Taiwan to evaluate this relationship. From the claims data, we established a cohort of women aged 15–50 years with primary dysmenorrhea diagnosed from 2000 to 2008 (n = 18,455) and a comparison cohort (n = 36,910) without dysmenorrhea, frequency matched by age and diagnosis date. Both cohorts were followed until the end of 2013 to assess IHD events. With 75% of study population aged 15–29 years, the incidence of IHD was greater in the dysmenorrheal cohort than in the comparison cohort (1.93 versus 1.18 per 10,000 person-years), with an adjusted hazard ratio of 1.60 (95% confidence interval [CI] = 1.38–1.85). The incidence increased with age and the rate of increase was greater in the dysmenorrheal cohort than the comparison cohort. Nested case-control analysis in the dysmenorrhea cohort showed that IHD risk was also associated with hypertension and arrhythmia, with adjusted odds ratios of 2.50 (95% CI = 1.64–3.81) and 3.30 (95% CI = 2.25–4.86), respectively. Women with dysmenorrhea are at a higher risk of developing IHD, particularly for older patients and patients with comorbidity.

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“…Strong evidence suggested migraine as a risk factor for ischemic stroke. Researches have also shown the positive link between migraine and ischemic heart disease, especially in migraineurs with aura 3 - 5 .…”

Section: Introductionmentioning

confidence: 99%

Risk of peripheral artery disease and stroke in migraineurs with or without aura: a nationwide population-based cohort study

Siao¹,

Su²,

Kuan³

et al. 2022

Int. J. Med. Sci.

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Background: Migraine is deemed a neurovascular disorder and there is growing evidence on the increased risk of cardiovascular disease, especially ischemic stroke, in patients with migraine. However the risk of peripheral artery disease (PAD) and stroke in migraineurs and the association between migraineurs with or without aura is still under debate. Our study aimed to identify the risk of PAD and stroke in migraineurs with or without aura. Methods: This was a population-based cohort study utilizing Taiwan Longitudinal Health Insurance Database (LHID2010). Patients with coding of migraine from 2002 to 2011 were enrolled and those with established cardiovascular disease defined as myocardial infarction, stroke, PAD, venous thromboembolism, atrial fibrillation and heart failure diagnosis before the index date were excluded. Participants were categorized into migraine group, migraine without aura group, and migraine with aura group respectively. The subjects in the three groups were propensity score-matched randomly to their counterparts without migraine. The study outcome was PAD and stroke. The Cox proportional hazard model was used to estimate the hazard ratios with 95% confidence interval (CI) for the association between migraine and the incident events of disease, after controlling for related variables. Results: The migraine, migraine without aura, and migraine with aura group included 5,173 patients, 942 patients and 479 patients respectively after propensity score-matching. The migraine group had an increased risk of PAD [adjusted hazard ratio (aHR): 1.93; 95% confidence interval (CI): 1.45-2.57; p < 0.001] and stroke (aHR: 1.55; 95% CI: 1.35-1.77; p < 0.001) compared to their non-migraine controls. Both the groups of migraine without aura and with aura had an increased risk of stroke (aHR: 1.49, 95% CI: 1.11-2.00; p = 0.008; aHR: 1.63, 95% CI: 1.10-2.43; p = 0.016). With regards to the outcome of PAD, the group of migraine with aura had a trend of an increased risk but did not reach statistical significance (aHR: 1.95, 95% CI: 0.86-4.40; p = 0.108). Conclusion: Migraineurs without established cardiovascular disease had a significantly increased risk of PAD and stroke, and the risk of stroke persists in migraineurs with or without aura, with an increased trend of PAD in migraineurs with aura. Our study result should remind clinical physicians of the risk of PAD in the future among migraineurs even without established cardiovascular disease currently, and screening for PAD and stroke may be needed in caring patients with migraine.

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Association of Migraine and Ischemic Heart Disease: A Review

Cited by 6 publications

References 33 publications

Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities

Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities

Risk of Ischemic Heart Disease Associated with Primary Dysmenorrhea: A Population-Based Retrospective Cohort Study

Risk of peripheral artery disease and stroke in migraineurs with or without aura: a nationwide population-based cohort study

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