Association of Mycoplasma penetrans with Human Immunodeficiency Virus Infection

Grau, Odile; Slizewicz, B; Tuppin, Philippe; Launay, Valérie; Bourgeois, Emmanuelle; Sagot, N; Moynier, Marinette; Lafeuillade, Alain; Bachelez, Hervé; Clauvel, Jean‐Pierre; Blanchard, Alain; Bahraoui, Elmostafa; Montagnier, Luc

doi:10.1093/infdis/172.3.672

Cited by 54 publications

(67 citation statements)

References 35 publications

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“…The profile of the LAMP fraction of Mycoplasma fermentans revealed 29, 38, 41, 61, 78, 95 and 150 kDa proteins. The bands p35 and p29 identified in this study are those referred in the literature as being specific for M. penetrans and M. fermentans (7,15,27) (Fig. 1).…”

Section: Resultssupporting

confidence: 70%

“…Proteins of 35 and 38 kDa, the two main lipoproteins used by M. penetrans to penetrate into the host cell (3,7), are the most abundant in mycoplasma cellular surface had have highfrequency phase variation (17). Our results showed a strong immunoreactivity these two proteins and the specie specificity of 35 kDa lipoprotein as previously found by Ferris et al, (5).…”

Section: Specific Reactivity For Speciessupporting

confidence: 84%

“…Studies with sera of HIV positive patients showed p35 and p38 to be immunodominant proteins (3,6,27). However, p35 and p38 was shown to be the specific lipoproteins for M. penetrans in Western blot with a high frequency of phase variation (7,19,20). These lipoproteins and their adhesins act as potent immunogens, determining the nature, intensity and multiple specificity of the host immune response.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Mycoplasma penetrans and Mycoplasma fermentans immunodominant proteins

Bruder

Godry

Takei

et al. 2005

Braz. J. Microbiol.

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Mycoplasmas are a heterogeneous group of the smallest organisms capable of self replication and are known to cause many detrimental diseases in both animals and humans. These wall-less prokaryotes are enveloped by a lipoprotein membrane and their small genomes are sufficient to synthesize molecules required for growth and self-replication. Among sixteen species isolated from humans, Mycoplasma pneumoniae, an agent of primary atypical pneumonia, and the urogenital tract species Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum have been confirmed to be pathogenic. Mycoplasma penetrans and Mycoplasma fermentans, which are species associated with HIV, have been investigated mainly in research laboratories. In this study we have characterized lipid-associated membrane proteins (LAMP) of Mycoplasma penetrans and Mycoplasma fermentans, in view of the importance of mycoplasmas in human diseases and the peculiar antigenic variation observed in these species. To characterize proteins with possible diagnostic value, we used ELISA and Western blot in sera of pregnant women whose cervical samples were positive for these species of mycoplasmas when tested by PCR. ELISA showed IgG anti-LAMP-M. fermentans antibodies to be present in 57.5% of cases and IgM antibodies to be present in 74.5% of cases. The three samples that were PCR positive for M. penetrans showed IgG anti-LAMP-M. penetrans antibodies, and one sample was positive for IgM. No IgA antibodies against either species were detected in any of the samples. LAMP analysis by Western blot revealed the 35, 38, 42, 61 and 103 kDa proteins of M. penetrans and the 29, 38, 41, 61, 78 and 95 kDa proteins of M. fermentans. Among these, will be considered p35 to M. penetrans and 29 kDa protein to M. fermentans, the main immunoreactive proteins and therefore useful markers for further laboratory diagnosis.

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Section: Resultssupporting

confidence: 70%

Section: Specific Reactivity For Speciessupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Characterization of Mycoplasma penetrans and Mycoplasma fermentans immunodominant proteins

Bruder

Godry

Takei

et al. 2005

Braz. J. Microbiol.

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“…M. pneumoniae and others induce depression in the immune response 65,66 , mainly of T cells, through a possible mechanism of apoptosis 67,68 , with a reduction in the CD4 T cells 69 , which may be a facilitating mechanism for other infections. This possible action of mycoplasmas, increasing the virulence of other agents, has been studied in AIDS patients 70 . Increased levels of cytokines and a low number of CD4 T cells are characteristics also present in unstable plaques.…”

Section: Discussionmentioning

confidence: 99%

Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction

Higuchi¹,

Reis²,

Sambiase³

et al. 2003

Arq. Bras. Cardiol.

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OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling)

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“…It is obviously too early to be able to draw conclusions about whether the findings of Tsai et al bear any relevance to oncogenesis in humans. The claims of Wang et al (467) that Kaposi's sarcoma is associated with M. penetrans infection were not verified by Grau et al (165). However, oncogenesis by mycoplasmas is a topic that offers an additional dimension to the pathogenic potential of mycoplasmas and certainly deserves further study.…”

Section: Clastogenic and Oncogenic Effectsmentioning

confidence: 97%

Molecular Biology and Pathogenicity of Mycoplasmas

2002

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Association of Mycoplasma penetrans with Human Immunodeficiency Virus Infection

Cited by 54 publications

References 35 publications

Characterization of Mycoplasma penetrans and Mycoplasma fermentans immunodominant proteins

Characterization of Mycoplasma penetrans and Mycoplasma fermentans immunodominant proteins

Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction

Molecular Biology and Pathogenicity of Mycoplasmas

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