Association of phthalates and early menarche in Korean adolescent girls from Korean National Environmental Health Survey (KoNEHS) 2015–2017

Park, One; Park, Jong-Tae; Chi, Youngchan; Kwak, Kyeongmin

doi:10.35371/aoem.2021.33.e4

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…This study detected that the mean level of monobutyl phthalates was higher in PP group than the control group and showed a significant difference. This was compatible with the third round of KoNEHS that was conducted by Park et al [33] to describe the Korean population and assess exposure levels to different chemicals in which they found that the possibility of early menarche was significantly increased in a high concentration of MnBP compared to low concentration. Furthermore, Zhang et al [43] found that phthalate metabolites levels (MMP, MnBP, mono(2-ethyl-hexyl) , and MEP) were related to increased breast development stage, rapid breast progression, and earlier menarche.…”

Section: Discussionsupporting

confidence: 85%

“…This agreed with Srilanchakon et al [31] who found significant difference between idiopathic precocious puberty, early puberty, and control regarding BMI and Hashemipour et al [32] who found significant difference between central precocious puberty group and control. It was contrary to Park et al [33] who reported that there was no significant difference between the early menarche group and the normal menarche. Also, Buluş et al [5] reported that there was no statistical difference between the CPP group, PPP group, and control regarding BMI.…”

Section: Discussioncontrasting

confidence: 79%

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The Possible Association between Phthalates and Bisphenol A Exposure and Idiopathic Precocious Puberty in Egyptian Girls

Mohsen

El-Zohairy

Hassan

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Bisphenol A (BPA) and phthalates are utilized in large spectrum of plastics, as polyvinyl chloride as well as personal products, medical equipment, and epoxy resins. Phthalate and bisphenol A are the most common endocrine disrupting chemicals that interrupt the endocrine system and cause developmental, reproductive, neurological, and immune disturbances in humans. However, the relation between phthalates and bisphenol A and precocious puberty (PP) in human is still controversial. AIM: Consequently, the present study aimed to detect and investigate the association between exposure to bisphenol A and monobutyl phthalate (MBP) and precocious puberty in Egyptian girls. METHODS: Urine samples were collected from 100 young females. The subjects were divided into two major groups, precocious puberty group consisted of 60 young females diagnosed by an endocrine pediatric specialist and controls consisted of 40 normal young females matched in age and demographic characters. In urine, MBP and bisphenol A (BPA) were measured with high-performance liquid chromatography. RESULTS: The mean concentration of MBP level was 22.758 ± 6.216 for the PP group and 15.283 ± 6.262 for controls with statistical difference between the studied groups (p < 0.001). Furthermore, the mean concentration of BPA was 405.02 ± 223.54 for the PP group and 97.95 ± 55 for controls with significant difference between groups (p < 0.001). CONCLUSION: The present study found that idiopathic precocious puberty in young females was associated with high phthalate metabolites and bisphenol A levels in urine.

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 79%

The Possible Association between Phthalates and Bisphenol A Exposure and Idiopathic Precocious Puberty in Egyptian Girls

Mohsen

El-Zohairy

Hassan

et al. 2022

Open Access Maced J Med Sci

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“…Modeling menarche [45,73,74] or early onset of menarche [75] as a binary outcome, four previous studies reported increased odds of (early) menarche in relation to phthalate exposure, which is consistent with our findings. In an 18-month follow-up study of 208 girls (6 to 13 years) from Shanghai, 5OH-MEHP and 5oxo-MEHP were associated with a 70% increase in the odds of having reached menarche [45].…”

Section: Epidemiological Evidence For Phthalatessupporting

confidence: 92%

PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies

Cox,

Wauters,

Rodríguez-Carrillo

et al. 2023

Toxics

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Early puberty has been found to be associated with adverse health outcomes such as metabolic and cardiovascular diseases and hormone-dependent cancers. The decrease in age at menarche observed during the past decades has been linked to an increased exposure to endocrine-disrupting compounds (EDCs). Evidence for the association between PFAS and phthalate exposure and menarche onset, however, is inconsistent. We studied the association between PFAS and phthalate/DINCH exposure and age at menarche using data of 514 teenagers (12 to 18 years) from four aligned studies of the Human Biomonitoring for Europe initiative (HBM4EU): Riksmaten Adolescents 2016–2017 (Sweden), PCB cohort (follow-up; Slovakia), GerES V-sub (Germany), and FLEHS IV (Belgium). PFAS concentrations were measured in blood, and phthalate/DINCH concentrations in urine. We assessed the role of each individual pollutant within the context of the others, by using different multi-pollutant approaches, adjusting for age, age- and sex-standardized body mass index z-score and household educational level. Exposure to di(2-ethylhexyl) phthalate (DEHP), especially mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), was associated with an earlier age at menarche, with estimates per interquartile fold change in 5OH-MEHP ranging from −0.34 to −0.12 years in the different models. Findings from this study indicated associations between age at menarche and some specific EDCs at concentrations detected in the general European population, but due to the study design (menarche onset preceded the chemical measurements), caution is needed in the interpretation of causality.

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“… 38 Since phthalates are used in almost all modern industries, studies to determine their health effects on humans have been widely performed. Phthalates are well known for their endocrine-disrupting mechanisms, including suppression of the reproductive tract, childhood obesity, early menarche, 38 39 and other adverse effects in various organs are actively revealed. MEOHP is a metabolite of di-2-ethylhexyl phthalate (DEHP).…”

Section: Discussionmentioning

confidence: 99%

Environment-wide association study of elevated liver enzymes: results from the Korean National Environmental Health Survey 2018–2022

Chi

Park

et al. 2023

Ann Occup Environ Med

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Background Environmental exposure is characterized by low concentration, chronic, and complex exposure. Traditional epidemiological studies show limitations in reflecting these characteristics since they usually focus on a single or very limited number of exposure factors at a time. In this study, we adopted the methodology of environment-wide association study (EWAS) to figure out the association of human liver function with various environmentally hazardous substances. Methods We analyzed 2,961 participants from the Korean National Environmental Health Survey Cycle 4 (2018–2020). Using generalized linear model (GLM) analysis, we analyzed the association of 72 variables with 3 liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]). Finally, we visualized our results with Manhattan plot. Results In GLM analysis, perfluorooctanesulfonate were positively associated with ALT (odds ratio [OR]: 2.2; 95% confidence interval [CI]: 1.39–3.46; p adjusted = 0.0147) and perfluorodecanoic acid showed positive association with GGT (OR: 2.73; 95% CI: 1.36–5.5; p adjusted = 0.0256). Plasma mercury showed positive association with GGT (OR: 1.45; 95% CI: 1.14–1.84; p adjusted = 0.0315). Using a plastic container while keeping food in the refrigerator was associated with elevated GGT compared to using a glass container (OR: 1.51; 95% CI: 1.16–1.95; p adjusted = 0.0153). 2-ethyl-5-oxohexyl phthalate, showed a negative trend with all 3 indices, with AST (OR: 0.54; 95% CI: 0.39–0.73; p adjusted = 0.00357), ALT (OR: 0.5; 95% CI: 0.34–0.75; p adjusted = 0.036), GGT (OR: 0.55; 95% CI: 0.4–0.76; p adjusted = 0.00697). Bisphenol S and frequent use of sunblock cream showed negative association with ALT (OR: 0.77; 95% CI: 0.66–0.89), and GGT (OR: 0.25; 95% CI: 0.11–0.55), respectively. Conclusions We conducted an exploratory study on environmental exposure and human liver function. By using EWAS methodology, we identified 7 factors that could have potential association with liver function.

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Association of phthalates and early menarche in Korean adolescent girls from Korean National Environmental Health Survey (KoNEHS) 2015–2017

Cited by 13 publications

References 48 publications

The Possible Association between Phthalates and Bisphenol A Exposure and Idiopathic Precocious Puberty in Egyptian Girls

The Possible Association between Phthalates and Bisphenol A Exposure and Idiopathic Precocious Puberty in Egyptian Girls

PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies

Environment-wide association study of elevated liver enzymes: results from the Korean National Environmental Health Survey 2018–2022

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