Association of polymorphisms in exons 2 and 10 of the insulin-like growth factor 2 (<i>IGF2</i>) gene with milk production traits in Polish Holstein-Friesian cattle

Bagnicka, Emilia; Siadkowska, E.; Strzałkowska, N.; Żelazowska, Beata; Flisikowski, Krzysztof; Krzyżewski, J.; Zwierzchowski, L.

doi:10.1017/s0022029909990197

Cited by 28 publications

(31 citation statements)

References 32 publications

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“…Other putative candidate genes included SMAD9, which encodes a protein with a potentially important role in follicular initiation and development (Xu et al 2015), GRIK2, which encodes a protein that plays important physiological roles in maturation and puberty (Widmann et al 2013), LRBA, which encodes a protein related to reproductive traits (Taye et al 2017), H19, which encodes a protein associated with embryogenesis and fetal growth in livestock species (Zaitoun and Khatib 2006) and IGF2, which encodes a protein considered to regulate the postnatal growth and differentiation of the mammary gland (Bagnicka et al 2010). The protein encoded byLSP1 has a negative regulatory role in leukocyte recruitment to sites of inflammation and in resistance/susceptibility to intestinal nematodes (Hou et al 2012a).…”

Section: Cnvr Gene Contents and Functional Annotationsmentioning

confidence: 99%

Genome-wide detection of copy-number variations in local cattle breeds

et al. 2019

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Abstract. The aim of the present study was to identify copy-number variations (CNVs) in Cinisara (CIN) and Modicana (MOD) cattle breeds on the basis of signal intensity (logR ratio) and B allele frequency of each marker, using Illumina's BovineSNP50K Genotyping BeadChip. The CNVs were detected with the PennCNV and SVS 8.7.0 software and were aggregated into CNV regions (CNVRs). PennCNV identified 487 CNVs in CIN that aggregated into 86 CNVRs, and 424 CNVs in MOD that aggregated into 81 CNVRs. SVS identified a total of 207 CNVs in CIN that aggregated into 39 CNVRs, and 181 CNVs in MOD that aggregated into 41 CNVRs. The CNVRs identified with the two softwares contained 29 common CNVRs in CIN and 17 common CNVRs in MOD. Only a small number of CNVRs identified in the present study have been identified elsewhere, probably because of the limitations of the array used. In total, 178 and 208 genes were found within the CNVRs of CIN and MOD respectively. Gene Ontology and KEGG pathway analyses showed that several of these genes are involved in milk production, reproduction and behaviour, the immune response, and resistance/susceptibility to infectious diseases. Our results have provided significant information for the construction of more-complete CNV maps of the bovine genome and offer an important resource for the investigation of genomic changes and traits of interest in the CIN and MOD cattle breeds. Our results will also be valuable for future studies and constitute a preliminary report of the CNV distribution resources in local cattle genomes.

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Section: Cnvr Gene Contents and Functional Annotationsmentioning

confidence: 99%

Genome-wide detection of copy-number variations in local cattle breeds

et al. 2019

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“…The results of the Bonferroni test were found to be significant (5%), and each animal that received the C allele tended to weigh on average 10.2 kg less than its contemporary. Several studies have investigated allelic profiles by SNP genotyping in cattle populations (Damiani et al, 2000;Flisikowski et al, 2005;de Souza et al, 2007;Andréa et al, 2007;Biase et al, 2007;Curi et al, 2009;Bagnicka et al, 2010;Souza et al, 2010). Up to 2009, around 500 bulls from 123 farms participating in the Genetic Improvement Program of the Nellore Breed in Brazil have been evaluated for the future multiplication of "positive animals" in commercial herds by artificial insemination, and of this total number, 25% were evaluated in the present study.…”

Section: Resultsmentioning

confidence: 99%

“…According to the average allelic effect, the animals that received the T allele (less frequent in the population) from the sire tended to have greater weight than their contemporary at this stage of life. In an association study of two SNPs located in the bovine IGF2 gene (exons 2 and 10) with milk production traits in dairy cattle, Bagnicka et al (2010) identified significant differences (P < 0.001) for the CT/GT haplotype. However, the same authors, in the analysis of the CT/GG haplotypes, verified that they seemed inferior for milk traits (daily yield, fat and protein content), and lower daily milk yield and lactose were associated with the genotype CT/GT, while the highest milk yield was associated with the genotypes TT/GG and CT/GG.…”

Section: Resultsmentioning

confidence: 99%

Association between IGF2 and CYP21 gene polymorphisms and characteristics of economic interest in Nellore cattle

Martins-da-Silva¹,

Rios²,

Ramos³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. We analyzed two single nucleotide polymorphisms (SNPs) of the IGF2 and CYP21 genes in Nellore cattle participating in the Brazilian Animal Breeding Program. The SNPs were found in exon 6 of the IGF2 (insulin-like growth factor 2) gene (RFLP/MboII) as well as in the promoter region of the CYP21 (steroid 21-hydroxylase) gene (RFLP/HpaII) of these animals. The TC heterozygotes were significantly more frequent than CC and TT homozygotes in the RFLP/ MboII polymorphism. The T allele was significantly more frequent than the C allele in RFLP/HpaII polymorphism. This population was found IGF2 and CYP21 gene polymorphisms in Nellore cattle to be in Hardy-Weinberg equilibrium for these SNPs. Association of these polymorphisms with expected progeny differences of reproductive and productive traits was investigated, but proved to be significant only for DP550 (expected progeny differenced for weight at 365 days -IGF2 -RFLP/MboII) and DP450 (expected progeny differenced for weight at 450 days -CYP21 -RFLP/HpaII). This is the first study on the occurrence of these two polymorphisms in this Zebu breed of cattle. A total of 147 Nellore animals participating in the Breeding Program of the Nellore Breed (PMGRN) under the management of the National Association of Breeders and Researchers (ANCP) in the city of Ribeirão Preto were analyzed.

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“…whether the allele is derived from the maternal or paternal line). The insulin-like growth factor 2 gene (IGF2) encodes an essential growth factor which is associated with both beef and milk production traits in cattle (Goodall and Schmutz, 2007;Flisikowski et al, 2007;Bagnicka et al, 2010). This gene is imprinted in a tissue specific manner (Gebert et al, 2006), indicating that epigenetic processes regulate the capture of these traits in any animal.…”

Section: Challenges and Future Researchmentioning

confidence: 99%

The integration of ‘omic’ disciplines and systems biology in cattle breeding

Berry

Meade

Mullen

et al. 2011

Animal

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Enormous progress has been made in the selection of animals, including cattle, for specific traits using traditional quantitative genetics approaches. Nevertheless, considerable variation in phenotypes remains unexplained, and therefore represents potential additional gain for animal production. In addition, the paradigm shift in new disciplines now being applied to animal breeding represents a powerful opportunity to prise open the 'black box' underlying the response to selection and fully understand the genetic architecture controlling the traits of interest. A move away from traditional approaches of animal breeding toward systems approaches using integrative analysis of data from the 'omic' disciplines represents a multitude of exciting opportunities for animal breeding going forward as well as providing alternatives for overcoming some of the limitations of traditional approaches such as the expressed phenotype being an imperfect predictor of the individual's true genetic merit, or the phenotype being only expressed in one gender or late in the lifetime of an animal. This review aims to discuss these opportunities from the perspective of their potential application and contribution to cattle breeding. Harnessing the potential of this paradigm shift also poses some new challenges for animal scientists -and they will also be discussed.

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Association of polymorphisms in exons 2 and 10 of the insulin-like growth factor 2 (IGF2) gene with milk production traits in Polish Holstein-Friesian cattle

Cited by 28 publications

References 32 publications

Genome-wide detection of copy-number variations in local cattle breeds

Genome-wide detection of copy-number variations in local cattle breeds

Association between IGF2 and CYP21 gene polymorphisms and characteristics of economic interest in Nellore cattle

The integration of ‘omic’ disciplines and systems biology in cattle breeding

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