Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

Abstract

SummaryEmerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.

A DRD1 Polymorphism Predisposes to Lung Cancer among Those Exposed to Secondhand Smoke during Childhood

“…It was surprising to us to find that an allele previously associated with nicotine dependence (28, 44) was significantly associated with a lower risk of lung cancer. However, we did not find an association between the SNP and cigarettes per day in either the NCI-MD or Wayne State studies (Supplementary Figure 2).…”

MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression

“…Down-regulation of miR-133a is associated with increased bronchial smooth muscle contraction in patients with asthma [41]. miR-133b negatively regulates the expression of transcription factor, Pitx3 [42], which activates the dopamine receptor (DRD1), a mediator of nicotine addiction in smokers [43]. Overall, emerging evidence of the biological roles of these miRNAs supports the plausibility of their involvement in lung diseases.…”

Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects

“…Association with nicotine dependence [12], tobacco smoking in schizophrenia [13], and alcohol dependence [14]. +1 rs686 62C > T 55 Higher DRD1 gene expression and association with nicotine dependence [12], alcohol dependence [15], and tobacco smoking in schizophrenia [13].…”

“…+1 rs686 62C > T 55 Higher DRD1 gene expression and association with nicotine dependence [12], alcohol dependence [15], and tobacco smoking in schizophrenia [13]. +1 D 5 DRD5 rs6283 978T > C 30 n/a n/a D 2 -like D 2 DRD2 rs1800497 2137G > A (also named TaqIA, aa exchange: Glu713Lys) 15 Lower striatal DR D 2 density in healthy subjects [16][17][18].…”