Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis

Saxena, Shweta; Madan, Taruna; Shah, Ashok; Muralidhar, K.; Sarma, P. Usha

doi:10.1067/mai.2003.1395

Cited by 124 publications

(70 citation statements)

References 33 publications

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“…England patients with 223Lys allele showed to increase affectability to meningococcal disease after neisseria meningitides infection (Jack et al 2006). It was also found that 223Lys allele mutation acted as a risk factor to increase the sensitivity to Aspergillus-mediated allergy in North Indian population (Saxena et al 2003). In contrast, we demonstrated that 223Gln allele may be a useful biomarker to predict susceptibility to r-UTI in Chinese women (p < 0.05).…”

Section: Discussionmentioning

confidence: 38%

Polymorphisms in the Surfactant Protein A Gene Are Associated with the Susceptibility to Recurrent Urinary Tract Infection in Chinese Women

Liu

Liang

et al. 2010

Tohoku J. Exp. Med.

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Recurrent urinary tract infection (r-UTI) remains one of the common infections affecting adult female. Almost 27% of women developed a recurrent UTI within the 6 months (Foxman 1990) and nearly 50% of women developed a recurrence within the first year following the initial infection (Mabeck 1972). Clinical studies showed that only a fraction of r-UTI patients had obvious functional, anatomic and behavioral risk factors, which were considered to be strongly associated with an increased risk of r-UTI. Recently, genetic studies have reported the associations of polymorphisms within innate immune molecules such as Toll-like receptor 2 and 4 (TLR2 and TLR4) with r

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Section: Discussionmentioning

confidence: 38%

Polymorphisms in the Surfactant Protein A Gene Are Associated with the Susceptibility to Recurrent Urinary Tract Infection in Chinese Women

Liu

Liang

et al. 2010

Tohoku J. Exp. Med.

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“…[11] suggested that genetic variation in Tolllike receptor-2 (TLR2) is a major determinant of the susceptibility to asthma and allergies. Novel single nucleotide polymorphisms (SNPs) in the gene for lung surfactant protein-A-2, a C-type lectin with an important role in host defence against Afu , were observed to be associated with ABPA patients in the Indian population [12].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Kaur

Gupta

Shah

et al. 2006

Clinical and Experimental Immunology

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SummaryMannan-binding lectin (MBL), an important component of innate immunity, binds to a range of foreign antigens and initiates the lectin complement pathway. Earlier studies have reported high plasma MBL levels in allergic patients in comparison to healthy controls. In view of varied plasma MBL levels being determined by genetic polymorphisms in its collagen region, we investigated the association of single nucleotide polymorphisms (SNPs) in the collagen region of human MBL with respiratory allergic diseases. The study groups comprised patients of bronchial asthma with allergic rhinitis ( n = = = = 49) and allergic bronchopulmonary aspergillosis (APBA) ( n = = = = 11) and unrelated agematched healthy controls of Indian origin ( n = = = = 84). A novel intronic SNP, G1011A of MBL , showed a significant association with both the patient groups in comparison to the controls ( P < < < < 0·01). Patients homozygous for the 1011A allele showed significantly higher plasma MBL levels and activity than those homozygous for the 1011G allele ( P < < < < 0·05). The 1011A allele also showed a significant correlation with high peripheral blood eosinophilia ( P < < < < 0·05) and low forced expiratory volume in 1 s (FEV 1 ) ( P < < < < 0·05) of the patients. We conclude that the 1011A allele of MBL may contribute to elevated plasma MBL levels and activity and to increased severity of the disease markers in patients of bronchial asthma with allergic rhinitis and ABPA.

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“…Ablation of SP-A and SP-D leads to enhanced eosinophilia and increases total IgE in AFU-sensitized mice (65,78). Additionally, evidence is accumulating that genetic polymorphisms of SP-A1 and SP-A2 are associated with increased susceptibility to ABPA (79,80). Moreover, treatment of AFU-sensitized WT and SP-A-and SP-D-deficient mice with "rescue" SP-A and SP-D, respectively, has been shown to suppress IgE levels, eosinophilia, cellular inflammation in the lung, and shift the pathogenic TH2 cytokine profile to a protective TH1 profile (75,81).…”

Section: Allergic Bronchopulmonary Aspergillosismentioning

confidence: 99%

Eosinophil-Associated Lung Diseases. A Cry for Surfactant Proteins A and D Help?

Ledford

Addison

Foster

et al. 2014

Am J Respir Cell Mol Biol

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Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.

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Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis

Cited by 124 publications

References 33 publications

Polymorphisms in the Surfactant Protein A Gene Are Associated with the Susceptibility to Recurrent Urinary Tract Infection in Chinese Women

Polymorphisms in the Surfactant Protein A Gene Are Associated with the Susceptibility to Recurrent Urinary Tract Infection in Chinese Women

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Eosinophil-Associated Lung Diseases. A Cry for Surfactant Proteins A and D Help?

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