Association of resistin and adiponectin with different clinical blood pressure phenotypes

Abstract

We investigated whether the resistin (Res) and adiponectin (Adp) levels are associated with different clinical blood pressure (BP) phenotypes. Among 465 consecutive never-treated white subjects, we excluded those with diabetes mellitus; impaired glucose metabolism; history of any cardiovascular disease or other concurrent medical condition; secondary hypertension; ongoing vasoactive treatment. Three separate clinic BP measurements and ambulatory BP monitoring were implemented to divide 328 subjects (aged 48±6 years; 172 males) into hypertensives (n ¼ 105), masked hypertensives (n ¼ 41), white-coat hypertensives (n ¼ 52) and normotensives (n ¼ 130). Participants underwent echocardiography and oral glucose tolerance testing, whereas, from fasting venous blood samples metabolic profile, plasma Res and Adp levels were assessed. Hypertensives and masked hypertensives showed higher log(10)(Res) and lower log(10)(Adp) levels compared with normotensives, whereas white-coat hypertensives had similar levels of these adipokines compared with normotensives. Common correlates for both of the adipokines were 24-h systolic BP, standing/sitting difference of both diastolic BP and heart rate, and waist circumference. Hypertensive and masked hypertensive compared with normotensive phenotype were independently associated with log(10)(Res) with odds ratios of 1.24 (1.08-1.44), and 1.16 (1.09-1.34) and log(10)(Adp) with 0.74 (0.65-0.87), and 0.81 (0.67-0.95), respectively. Increased Res and decreased Adp plasma levels are associated with out-of-clinic hypertension, whereas they did not determine whitecoat hypertension.

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

“…Meanwhile, significant increases in BMI, random blood sugar, HbA1c, and resistin level were observed in the diabetic children compared with the control group (p < 0.0001). This agreed with a recent study of Yazıcı et al (28) that reported higher resistin levels in type-1 diabetic patients compared with the controls, as well as many other studies (29,30). Conversely, a previous work of Schäffler et al reported lower resistin concentrations in adult patients with type-1 diabetes compared with healthy control subjects with a similar age range.…”

Metabolic risk factors and masked hypertension in the general population: the Finn-Home study

“…That study performed ambulatory BP measurement on 328 untreated, non- proportion of the syndrome was higher in masked (29%) and sustained hypertension (30%) than in normotension (12%) or white-coat hypertension (17%). 15 The prevalence of harmonised MS was similar in the untreated Finn-Home study population and in the larger sample of the Health 2000 survey. 1 In the present study, MS was two to three times more common in masked and white-coat hypertension than in normotension when EGIR or harmonised definition was used.…”

“…[14][15][16][17][18][19][20] Although the prevalence of MS varies widely depending on the definition used, only three studies reported criteria for the syndrome. [14][15][16] Only a Korean study defined masked hypertension using home BP measurement but it investigated treated hypertensive patients. [17][18][19] The majority of the previous studies did not find any significant differences in MS between the BP groups 14,16-20 but only one study investigated all four BP subgroups.…”

“…Although patients with MS frequently have high-normal or elevated office, home and ambulatory BP levels, only a few studies have touched briefly on MS or insulin resistance in masked hypertension. 5,7,[14][15][16][17][18][19][20][21][22][23][24] Most of these studies were based on selected patient groups [14][15][16][17][18][19][20][22][23][24] and only a few of them reported the criteria used to define MS. [14][15][16] The majority of them did not find any significant differences between BP subgroups.…”

Free Leptin Predicts Incident (Clinic) Hypertension in a Danish Cohort

“…In two different outpatient samples, we have previously demonstrated that white-coat hypertension was not associated with either free leptin or adiponectin; however, both of these adipokines were associated with sustained and masked hypertension. 3,4 Consequently, we believe that white-coat phenomenon might not have affected the results of the Danish prospective study, 1 and this is further supported when harder criteria for the definition of the outcome were implemented (i.e., systolic BP ≥160 mm Hg and/or diastolic BP ≥95 mm Hg). In contrary, masked hypertension phenomenon would have diminished and convicted as not significant of the predictive value of leptin and adiponectin on incident hypertension, respectively.…”