Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep

Lenis-Valencia, Claudia Patricia; Franco, Luz Ángela Álvarez; Hernández-Herrera, Darwin

doi:10.1007/s11250-022-03086-x

Cited by 13 publications

(10 citation statements)

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“…Several studies have reported the behavior of growth variables in OPC lambs. The BW was lower than that presented by Montes-Vergara et al [ 3 ] (2.8 ± 0.21 kg), Vergara et al [ 4 ] (2.6 ± 0.6 kg), Palacios et al [ 2 ] (2.8 ± 0.8 kg), Noriega et al [ 5 ] (3.2 ± 0.5 kg), and Lenis et al [ 12 ] (3.10 ± 0.70 kg). These differences are associated with the number of lambs at birth [ 34 ], ewe age [ 35 , 36 ], the feeding management of the pregnant ewes during the last third of gestation [ 37 ], and the male used during the breeding season [ 3 ].…”

Section: Discussioncontrasting

confidence: 59%

“…Advances in genomic association studies have made it possible to identify candidate genes with a greater effect on growth traits and carcass and meat quality [ 10 ]. One of these candidate genes is the melanocortin-4 receptor (MC4R, GeneID: 100147707) [ 11 ], which has not been studied in the OPC [ 12 ]. MC4R is one of the five currently identified melanocortin receptors that belong to the G-protein receptor family and encodes a seven-domain transmembrane protein [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of the MC4R gene with growth traits and meat quality in Colombian hair sheep

Herrera,

lez,

rez

2023

J Adv Vet Anim Res

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Objective: The objective of this study was to associate the 1016G > A variant of the melanocortin-4 receptor gene with lamb’s weight, growth, and meat quality in the Colombian hair sheep breed. Materials and Methods: A total of 168 lambs, weights were measured at birth weight (BW), at weaning adjusted weaning weight (AWW), at 6 months [adjusted weight (AW180)], at slaughter adjusted slaughter weight (ASW), daily weight gain preweaning daily gain (preWDG), and postweaning daily gain (postWDG) weaning, and after slaughter, pH, texture, and cook-loss (CL) in the longissimus thoracis et lumborum (LTL) muscle according to the American Meat Science Association methodology. The 1016G > A genotypes were obtained by sequencing. Genotypic and allele frequencies, heterozygosities, and Hardy–Weinberg equilibrium (HWE) were estimated. Using a generalized linear model, the genotype and the allelic substitution effect were associated with the evaluated traits. Results: The heterozygous genotype (0.48) and G allele (0.61) were the most frequent. Heterozygosities were similar (0.47), indicating HWE. The genotype affected the BW (p < 0.05), with a higher value for the GG genotype (2.69 kg). AWW (12.75 kg), AW180 (19.67 kg), and ASW (31.21 kg) weights and daily weight gain (preWDG = 115.41 gm; postWDG = 96.16 gm) were not associated. Average pH, Warner-Bratzler shear force, and CL were 5.75 units, 49.46 N, and 32.02%, with no genotype effect. The G > A substitution only affected BW at −388 gm (p < 0.05). Conclusion: The 1016G > A variant is polymorphic and affects the BW but not other growth traits or the meat quality of the LTL muscle.

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Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Association of the MC4R gene with growth traits and meat quality in Colombian hair sheep

Herrera,

lez,

rez

2023

J Adv Vet Anim Res

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“…SNPs are de ned as substitutions, insertions, or deletions of single nucleotides and are important in animal breeding 35 . Determining the correlation between the loci of candidate SNPs and the economic traits of animals is an effective method for identifying new genetic markers, facilitating the accurate and e cient analysis of genetic diversity in breeding programs 36,37 . Protein function and gene expression are associated with the location of the SNP, whether in regulatory sequences or coding regions 38 .…”

Section: Discussion 1 Genetic Characterization Of Acacb In the Gannan...mentioning

confidence: 99%

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

zhu,

Wang,

et al. 2024

Preprint

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Acetyl-CoA carboxylase beta (ACACB) is a rate-limiting enzyme involved in lipid syn-thesis and fatty acid oxidation. The results of our previous study showed that a total of seven SNPs were detected in the exon 37-intron 37, exon 46-intron 46, and intron 47 regions of the yak ACACB, and mutations in the ACACB were found to affect yak meat quality traits. However, the genetic effects of ACACB on yak milk quality traits have not been reported. Therefore, the aim of this study was to investigate the effects of ACACB polymorphisms on yak milk quality traits in Gannan yaks. In this study, A total of 202 Gannan yaks were included in the study. Analyze the different geno-types, diplotypes, and the presence or absence of haplotypes on milk quality. The seven SNPs were named as exon 37-intron 37 (exon 37: SNP1, intron 37: SNP2 and SNP3), exon 46-intron 46 (exon 46: SNP4, intron 46: SNP5), and intron 47 (SNP6 and SNP7). Apart from the SNP1, SNP2, SNP5, and SNP6 loci where the polymorphic information content (PIC) was low (PIC ≤ 0.25), the SNP3, SNP4, and SNP7 loci were all of intermediate polymorphic information status (0.25 < PIC < 0.5). The highest frequency of heterozygosity occurred at the SNP7 locus, and the two alleles were evenly distributed in the population compared to alleles at the other loci. There were no strong linkages between the SNPs (r2<0.33) except for a strong linkage disequilibrium observed between SNP1 and SNP2 (r2=0.89). Seven effective haplotypes and seven diplotypes were constructed for the Gannan yak ACACB gene. Correlation analysis showed that SNP1 and SNP7 were associated with lactose content (P<0.05), while SNP3 was significantly associated with the protein and monounsaturated fatty acid contents in the milk (P<0.05). SNP4 was significantly associated with both saturated and monounsaturated fatty acid contents (P<0.05 and P<0.01, respectively), while SNPs 5 and 7 were significantly correlated with the fat percentage (P<0.05) and SNP6 was significantly correlated with total solid content of the milk (P<0.05). Yaks with the H2H2 diplotype had significantly higher levels of milk fat than other diplotypes (P<0.05) while milk fat contents in animals carrying hap-lotype H2 were significantly higher than that in yaks carrying the deletion type (P<0.05). The findings of the present study suggest that polymorphisms in the yak ACACB affect milk quality and can be used as genetic markers for enhancing milk quality in yak populations. The findings provide a theoretical basis for the genetic characterization of milk quality traits in the Gannan yak.

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“…The GnRH gene as one of the vital candidate genes was significantly related to major economic traits such as quail growth and carcass ( Bai et al, 2021 ). Identification of single nucleotide polymorphism ( SNP ) in candidate genes and its correlation with economic traits in animals was a powerful method to identify new genetic markers to more accurately select animals to improve growth performance ( Bhattacharya et al, 2019 ; Shafey et al, 2020 ; Valencia et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Research Note: Polymorphisms of gonadotrophin-releasing hormone gene and their association with growth traits in quail (Coturnix Coturnix)

Wang¹,

Li²,

Bai³

et al. 2023

Poultry Science

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Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep

Cited by 13 publications

References 44 publications

Association of the MC4R gene with growth traits and meat quality in Colombian hair sheep

Association of the MC4R gene with growth traits and meat quality in Colombian hair sheep

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

Research Note: Polymorphisms of gonadotrophin-releasing hormone gene and their association with growth traits in quail (Coturnix Coturnix)

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