Association of single nucleotide polymorphisms of interferon-γ with pulmonary tuberculosis in population of Himachal Pradesh, India

Dhiman, Nain Singh; Saini, Varinder; Kumar, Vijay

doi:10.1016/j.gene.2022.146392

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…Genetic changes of IFNs are associated with TB susceptibility. Mutations in IFN-γ confer different susceptibilities to different M. tuberculosis strains [ [44] , [45] , [46] ]. Susceptibility to atypical TB might be associated with mutations in one of the five genes in the IFN-γ pathway [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated sequence-based genomic, transcriptomic, and methylation characterization of the susceptibility to tuberculosis in monozygous twins

Liu,

Deligen,

Han

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Integrated sequence-based genomic, transcriptomic, and methylation characterization of the susceptibility to tuberculosis in monozygous twins

Liu,

Deligen,

Han

et al. 2024

Heliyon

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“…Both IFN-γ knockout models in mice [ 15 ], as well as specific deficiencies in the IFN-γ pathway in humans, are associated with fatal disseminated mycobacterial infection [ 16 ]. In humans, IFN-γ gene polymorphisms are associated with an increased risk of LTBI [ 17 ] and the development of active TB [ 18 ]. Furthermore decreased IFN-γ was associated with severe TB disease [ 19 ], and increased IFN-γ production was associated with clinically cured TB [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis

et al. 2023

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Background Interferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and immune recovery during treatment is unexplored. We investigated the species-specific effect of helminths on the IFN-γ production by T cells in relation to disease severity during active and latent TB infection (LTBI). Methods In this study, 69 active pulmonary TB patients (PTB), 28 with LTBI and 66 healthy controls were included. Active TB was diagnosed using GenXpert MTB/RIF while QuantiFERON test (QFT) was used for the screening of healthy community controls (CCs) and for the diagnosis of LTBI. Helminth infection was identified by routine diagnosis whereas clinical disease severity was evaluated by the TB score. Intracellular IFN-γ production of T cells in stimulated peripheral blood mononuclear cells (PBMCs) was analyzed by flow cytometry using TB antigens (PPD), the polyclonal T cell activator staphylococcal enterotoxin B (SEB), or medium as unstimulated control. Results Helminth infected CCs and LTBI subjects showed a significant reduction of IFN-γ+ CD4+ T cells by PPD-stimulation compared to non-helminth infected control groups. The significant reduction in the frequency of IFN-γ+ T cells in both latent and active PTB patients following SEB stimulation was mostly attributed to Schistosoma mansoni infection, whereas Ascaris lumbricoides, Schistosoma mansoni, and hookworm infection contributed equally in CCs. Following anti-helminthic and anti-TB treatment for 2 months, the frequency of IFN-γ+ CD4 T cells in helminth coinfected PTB was restored to levels of helminth negative PTB before treatment. Helminth coinfected PTB patients with an intermediate and severe clinical course had reduced capacity for production of IFN-γ+ T cells compared to the corresponding non-helminth infected PTB. Conclusion We found a reduction in IFN-γ producing T cells by helminth coinfection which was restored following anti-helminthic treatment. This reduction was helminth species-dependent in an exploratory sub-analysis and correlated to increased disease severity.

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Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India

Kumari,

Saini,

Kumar

2024

Mol Biol Rep

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Association of single nucleotide polymorphisms of interferon-γ with pulmonary tuberculosis in population of Himachal Pradesh, India

Cited by 6 publications

References 31 publications

Integrated sequence-based genomic, transcriptomic, and methylation characterization of the susceptibility to tuberculosis in monozygous twins

Integrated sequence-based genomic, transcriptomic, and methylation characterization of the susceptibility to tuberculosis in monozygous twins

Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis

Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India

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