Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing loss

Abstract

Our results suggest that the T allele of MTHFR C677T could be associated with susceptibility to SSNHL, and even imply that this mutation could be a risk factor that is independent of blood folic acid and homocysteine.

Idiopathic Sudden Sensorineural Hearing Loss: Classic Cardiovascular and New Genetic Risk Factors

“…In our view, these differences can be explained by environmental influences linked to classical cardiovascular risk factors. For example, the mean age of patients in the study by Uchida et al [2010] was about 10 years higher than in studies conducted in Europe [Capaccio et al, 2005;Marcucci et al, 2005;Rudack et al, 2006;Cadoni et al, 2010;Mosnier et al, 2011]. Despite these differences, however, our case group did not show an excess of cardiovascular risk factors.…”

“…Unfortunately, the lack of certain specific data does not enable full comparisons between these series [Capaccio et al, 2005;Marcucci et al, 2005;Rudack et al, 2006;Lin et al, 2008;Cadoni et al, 2010;Uchida et al, 2010;Mosnier et al, 2011]. Analogous data were observed in other studies for the cardiovascular and neurovascular risk profiles [Capaccio et al, 2005;Marcucci et al, 2005;Rudack et al, 2006;Lin et al, 2008;Cadoni et al, 2010;Uchida et al, 2010;Mosnier et al, 2011]. Lin et al [2008] compared the presence of stroke in cohorts of appendectomy and iSSNHL patients.…”

Polymorphisms in Genes Involved in Oxidative Stress Response in Patients with Sudden Sensorineural Hearing Loss and Ménière's Disease in a Japanese Population

“…In SSNHL, significant associations have been reported mainly for polymorphisms in genes related to blood vessels, circulation, or inflammation, including protein kinase C eta type (1425G/A), matrix metalloproteinase-1 ( -1607G/2G), interleukin 1A ( -889C/T), interleukin 6 ( -572C/G), methylenetetrahydrofolate reductase (C677T), prothrombin (G20210A), platelet Gly IIIaA1/ A2, and factor V Leiden (Capaccio et al, 2005a(Capaccio et al, , 2005b(Capaccio et al, , 2007(Capaccio et al, , 2009Uchida et al, 2010Uchida et al, , 2011Furuta et al, 2011;Nam et al, 2011;Hiramatsu et al 2012). In Ménière's disease, significant associations have been reported for genetic polymorphisms, such as those in the KCNE potassium channel genes (in the Japanese population, but not in Caucasians), adducin 1 (Gly460Trp), heat-shock protein 70-1 (190G/C), and interleukin 1A (-889C/T) (Doi et al, 2005;Kawaguchi et al, 2008;Teggi et al, 2008;Campbell et al, 2010;Furuta et al, 2011).…”

Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss

“…SD is thought to have multiple causes, including genetic and environmental factors. To date, some gene polymorphisms have been identified for the vasculature-or inflammation-related pathogenesis of SD, such as protein kinase C-eta 1425G/A, matrix metalloproteinase-1 1607G/2G, methylenetetrahydrofolate reductase 677C/T, prothrombin 20210G/A, platelet Gly IIIaA1/A2, factor V Leiden 1691G/A, interleukin-1A-889C/T, interleukin-6C 572C/G, complement factor H 402Y/H, and nitric oxide synthase 3 894G/T Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss polymorphisms [4][5][6][7][8][9][10][11][12][13] . Environmental factors related to lifestyle, including short sleeping times, heavy smoking, alcohol abuse, and fatigue, have been found to be risk factors for SD [14,15] .…”