Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer

Abstract

BackgroundSeveral inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.MethodsThis study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.ResultsThe preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.ConclusionThese results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.

Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma

“…On the other hand, Yaylaci et al, observed no significant relationship between NLR and PTC (13). Kim SM et al, also reported a lack of significant relationship between preoperative NLR levels and clinicopathological characteristics of PTC in patients with PTC (31). Similar to these reports, no significant relationship was observed between the patient groups in terms of NLR levels in the current study.…”

“…Kim SM et al, investigating the clinicopathological characteristics of patients with papillary thyroid carcinoma, did not find any significant relationship between NLR and tumor size, and multifocality. However, they reported a significant relationship between tumor size and PLR (31). On the other hand, Gong W et al, reported that the tumor size and multifocality correlated with the NLR values.…”

Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

“…Therefore, 7 studies comprising 7349 patients, published between 2013 and 2015, were included in the present meta-analysis4121314151617 (Table 1). Three studies were conducted in Korea12151617, three studies were performed in China, and one in Turkey13.…”

“…Three studies were conducted in Korea12151617, three studies were performed in China, and one in Turkey13. NOS18 scores of the studies ranged from 7 to 8, with a mean value of 7.71.…”

“…However, Liu et al 14. and Kim et al 15. found that there was no difference in the NLRs between patients with benign or malignant thyroid nodules in the overall population.…”