Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients

Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans

“…In addition, we found no association with the well-known TNF-308/rs1800869*A, which has been associated with high production of TNFa 39 and clinically with rheumatoid arthritis in Egyptians and Brazilians, 40,41 lupus nephritis in Portuguese individuals 42 and type 1 diabetes in Asians. 43 Both BAT1(intron10)*C and TNF-308*A mark FV16 and the 8.1 ancestral haplotype (HLA-A1, B8, DR3, DQ2).…”

Association of Tumor Necrosis Factor-Alpha -308 G>A Polymorphism With Rheumatoid Arthritis in Two North Indian Cohorts

“…The frequency in the control population of Punjab (cohort 1) was 8.3%, which was similar to Chinese (7.7%) 3 and Czech (9.7%), 10 and higher than Japanese (3.3%), Egyptian (3.1%) populations, and the North Indian (4.9%) population from Uttar Pradesh. [32][33][34] The frequency in cohort 2 comprising the Jammu and Kashmir population (25%) was nearly similar to that reported in European populations including North Swedish (24%), 19 Dutch (23.8%), 35 and Netherlands (19%) 36 but lower than Saudi Arabian (31.0%) 28 population. The frequency of A allele in Jammu and Kashmir was higher compared to the population of Punjab.…”

Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin–Beck disease in Northwest Chinese population

“…TNF-α, as an important inflammatory cytokine, which is produced by monocyte macrophages, T and B cells and whose gene lies in the class III region of the major histocompatibility complex and locates in the human chromosome 6p21.3, plays a central role in inflammation by inducing the expression of other pro-inflammatory and chemotactic cytokines and adhesion factors [15,16]. The polymorphism in the promoter region of the TNF-α may be very important in determining the host's TNF-α response, and the polymorphisms have also been described to be associated with the outcome and progression of rheumatoid arthritis [17], osteoarthritis [18,19], ankylosing spondylitis [20], etc.…”