Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India

Saraswathy, Kallur Nava; Ansari, Shagufta Naaz; Kaur, Gurjinder; Joshi, P. C.; Chandel, Shivani

doi:10.1016/j.clnesp.2019.01.009

Cited by 24 publications

(17 citation statements)

References 24 publications

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“…All studies were published from 2000 to 2020. Overall, in this meta‐analysis, 46 studies, 17,22‐66 which enrolled a total of 34 873 participants (mean age = 56.5 years), were included.…”

Section: Resultsmentioning

confidence: 99%

The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies

Moradi

Lotfi

Armin

et al. 2021

Eur J Clin Investigation

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Background: Hyperhomocysteinaemia is known to interfere with neurological functions; however, there is a controversy regarding the relationship between homocysteine and depression. Materials and methods: Science Direct, MEDLINE and ISI Web of Science were searched to find relevant articles, published up to August 2020. Studies were included if they compared homocysteine levels in healthy subjects with subjects with depression. Also, articles that reported the association between hyperhomocysteinaemia and risk of depression were included. Odds ratios of depression and means of homocysteine were used to ascertain the overall effect size. Results: Homocysteine level was higher in subjects with depression in comparison with healthy controls (weight mean difference = 2.53 µmol/L, 95% confidence interval: 1.77, 3.30), and the depression diagnostic tool was a source of heterogeneity.Homocysteine level was significantly higher in subjects with depression in studies that used Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV), Geriatric Depression Scale (GDS), Zung Self-Rating Depression Scale (ZDRS) and Beck Depression Index II (BDI-II) as depression diagnostic tools. Also, participants with hyperhomocysteinaemia had a higher chance of depression (Pooled risk = 1.34, 95% confidence interval: 1.19, 1.52), where the depression diagnostic tool was a source of heterogeneity. In contrast to ZDRS and Patient Health Questionnaire (PHQ) subgroups, hyperhomocysteinaemia yielded a significantly higher risk of depression in DSM-IV, GDS and 'other' subgroups. Conclusion: Homocysteinemia level is higher in individuals with depression.However, the depression diagnostic tool used is instrumental in influencing their association, and thus, future studies should focus on the tools for depression assessment.

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Section: Resultsmentioning

confidence: 99%

The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies

Moradi

Lotfi

Armin

et al. 2021

Eur J Clin Investigation

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“…Çocuk ve ergenlerde vitamin B12 eksikliği nörolojik ve psikiyatrik bozukluklara neden olabilir (9). Vitamin B12 eksikliğinin depresyonla ilişkili olduğu ve depresyon gelişen hastalarda vitamin B12 takviyesiyle depresyon tedavisine daha iyi yanıt alındığı randomize kontrollü çalışmalarda gösterilmiştir (21)(22)(23).…”

Section: Discussionunclassified

Experimental Animal Models Experiment Used to Develop Polycystic Ovarian Syndrome

Tokmak¹,

Ersak²,

Şahin³

2019

btd

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Amaç: Gerilim tipi baş ağrısı olan çocuklarda vitamin B12 eksikliği sıklığını belirleyerek gerilim tipi baş ağrısı ile vitamin B12 eksikliği arasındaki ilişkiyi incelemeyi amaçladık. Yöntemler: Çocuk nörolojisi polikliniğinde 1 Haziran 2018 ile 31 Aralık 2018 tarihleri arasında gerilim tipi baş ağrısı tanısı alan çocuklar çalışmaya dahil edildi. Bilinen kronik hastalığı olan, diyet takviyesi alan veya herhangi bir ilaç kullanan çocuklar çalışmadan çıkarıldı. Hastaların demografik özellikleri, ilk başvurudaki tam kan sayımı, serum vitamin B12, folat, homosistein değerleri ile idrar metilmalonik asit düzeyleri kaydedildi. Kontrol grubu akut veya kronik bir hastalığı olmayan, diyet takviyesi veya herhangi bir ilaç kullanmayan çocuklardan oluşturuldu. Bulgular: Gerilim tipi baş ağrısı tanılı 76 hasta (57 kız, 19 erkek) ve kontrol grubunda 79 çocuk (51 kız, 28 erkek) olmak üzere toplam 155 çocuk çalışmaya dahil edildi. Serum vitamin B12 düzeyi ortalaması gerilim tipi baş ağrısı olanlarda 210,6±104 pg/mL (43-534 pg/mL), kontrol grubunda ise 260,6±109 pg/mL (104-712 pg/mL) idi. İki grup arasında vitamin B12 düzeyleri arasında istatiksel olarak anlamlı fark saptandı (p=0,005). Gerilim tipi baş ağrısı olan 46 hastada (%61) vitamin B12 eksikliği mevcuttu. Kontrol grubunda 30 çocukta (%38) vitamin B12 eksikliği saptandı. İki grup arasında vitamin B12 eksikliği açısından istatiksel olarak anlamlı fark saptandı (p=0,032). Sonuç: Çalışmamızda, gerilim tipi baş ağrısı olan çocukların yarısından fazlasında vitamin B12 eksikliği mevcuttu. Gerilim tipi baş ağrısı olan çocukların vitamin B12 eksikliği açısından değerlendirilmesinin önemli olacağını düşünmekteyiz.

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“…Prescribing isotretinoin for patients with current history or having active signs of depression should be taken with caution (Daunton, Oyebode, & Goulding, 2019). Hyperhomocysteinemia was associated with more than threefolds and sixfolds increased risk for the development of depression and generalized anxiety disorder, respectively (Saraswathy, Ansari, Kaur, Joshi, & Chandel, 2019). Starting Vitamin B12 and folic acid replacement alongside isotretinoin could prevent folic acid deficiency and improving blood homocysteine levels possibly reducing the possible risk for neuropsychiatric disorders in patients under isotretinoin (Ghiasi, Mortazavi, & Jafari, 2018).…”

Section: Low-dose Isotretinoin Therapy In Patients With Neuropsychimentioning

confidence: 99%

Low dose of isotretinoin: A comprehensive review

Abdelmaksoud

Lotti

Anadolu

et al. 2020

Dermatologic Therapy

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Isotretinoin is a first‐generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti‐inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date‐unlimited PubMed search, from inception till December 2019, using the following search terms: “low‐dose isotretinoin” and “dermatology,” “isotretinoin and safety,” “isotretinoin, off‐label uses,” “isotretinoin and male fertility,” “isotretinoin, iPLEDGE system,” aiming to deliver a therapeutic update relevant to clinical practice. All English‐language articles were considered with no limitation based on the articles' type. Low‐dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.

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Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India

Cited by 24 publications

References 24 publications

The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies

The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies

Experimental Animal Models Experiment Used to Develop Polycystic Ovarian Syndrome

Low dose of isotretinoin: A comprehensive review

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