Association ofp53 codon arg72pro andp73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the risk of japanese breast cancer

Abstract

This study implies an association of breast cancer risk with the p53 polymorphism Arg72Pro, but not with p73 G4A.

Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population

“…Several studies investigated the associations between the p73 G4C14-to-A4T14 polymorphism and cancer risk. [17][18][19][20][21] In an early small case-control study of 84 cases of esophageal cancer and 152 age-and sex-matched normal controls in an Irish population, the variant AT/AT homozygous genotype appeared to protect against the development of esophageal cancer, 17 which is consistent with our results of lung cancer. The genotype frequencies among the Irish controls were 47.3% for GC/GC, 42.8% for GC/AT and 9.9% for AT/AT, 17 comparable to 50.2% GC/GC, 42.2% GC/AT and 7.7% AT/AT in our controls.…”

“…10 The molecular epidemiological studies has encouraged to evaluate the association between these polymorphisms in p73 and risk of human cancer. [17][18][19][20][21] However, the results of published studies are confusing rather than conclusive and all published studies to date suffered from limited statistical power due to small sample size (the number of subjects in case group were all Ͻ 200). To further test the hypothesis that the p73 G4A and C14T dinucleotide polymorphisms are associated with risk of lung cancer, we conducted a relatively large case-control study of 425 patients with incident lung cancer and 588 cancer-free controls frequency-matched to the cases on age and sex in a Chinese population.…”

Association between a p73 Gene Polymorphism and Genetic Susceptibility to Non-small Cell Lung Cancer in the South of China

“…Prior researches on the correlation between the two polymorphisms and other tumors were discussed, but the conclusion was inconsistent (Ryan et al, 2001;Huang et al, 2003;Ni et al, 2004;Li et al, 2004;Pfeifer et al, 2005;Lee et al, 2010). This paper was based on the case-control study, detecting the p73 gene polymorphism by using HRM and PCR-CTPP, at last in combination with DNA sequencing to verify, to explore the association between p73 gene polymorphism and genetic susceptibility to lung cancer in Chinese population.…”

“…For amplification, primers were shown in Table 1 (Huang et al, 2003;Lee et al, 2010), Real-time PCR was carried out with a 25μl reaction mixture containing SYBR mixture 12.5μl, sterilized water 10.5μl, each primer 0.5μl, DNA template 1μl. An initial denaturation step at 94℃for 5 min was followed by 30 cycles of 94℃ for 30s, 65℃ for 30s, 72℃for 30s, and a final extension step at 72℃ for 10 min.…”

Biological significance of allele specific loss of the p53 gene in breast carcinomas

“…The Pro/Pro genotype, on the other hand, appears to induce higher level of G1 arrest than does the Arg/Arg genotype [6]. The contribution of codon 72 to breast cancer risk has been investigated by several authors but results are diverse so its implication remains uncertain [8][9][10][11][12][13].…”