Association ofSOD3 promoter DNA methylation with its down-regulation in breast carcinomas

Griess, Brandon; Klinkebiel, David; Kueh, Alice; Desler, Michelle; Cowan, Kenneth H.; Fitzgerald, Matthew P.; Teoh-Fitzgerald, Melissa

doi:10.1080/15592294.2020.1777666

Cited by 17 publications

(9 citation statements)

References 37 publications

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“…That is, significantly higher cytosine methylation in the EcSOD promoter regulatory region corresponded to cells and tumor samples with decreased EcSOD [ 37 ] ( Figure 2 D). Similar epigenetic modifications were found in breast cancer, where a significant increase in the methylation of the EcSOD promoter in patients with breast cancer compared to controls was identified [ 45 , 46 ]. In another study, combined bisulfite restriction analyses of in vivo tumor samples demonstrated an association of DNA methylation with the loss of EcSOD expression [ 38 ].…”

Section: Ecsodsupporting

confidence: 61%

Impact of EcSOD Perturbations in Cancer Progression

et al. 2021

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Reactive oxygen species (ROS) are a normal byproduct of cellular metabolism and are required components in cell signaling and immune responses. However, an imbalance of ROS can lead to oxidative stress in various pathological states. Increases in oxidative stress are one of the hallmarks in cancer cells, which display an altered metabolism when compared to corresponding normal cells. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide anion (O2−) in the extracellular environment. By doing so, this enzyme provides the cell with a defense against oxidative damage by contributing to redox balance. Interestingly, EcSOD expression has been found to be decreased in a variety of cancers, and this loss of expression may contribute to the development and progression of malignancies. In addition, recent compounds can increase EcSOD activity and expression, which has the potential for altering this redox signaling and cellular proliferation. This review will explore the role that EcSOD expression plays in cancer in order to better understand its potential as a tool for the detection, predicted outcomes and potential treatment of malignancies.

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Section: Ecsodsupporting

confidence: 61%

Impact of EcSOD Perturbations in Cancer Progression

et al. 2021

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“…Superoxide dismutase 3 (SOD3) was down-regulated in the HNPGL tumor tissue. SOD3 was also down-regulated in a number of malignancies, including breast, lung, pancreas, and colorectal carcinomas, and was related to regulation of HIF-1 expression [ [25] , [26] , [27] ]. NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 (NDUFA2) showed the most significantly increased expression.…”

Section: Resultsmentioning

confidence: 99%

High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma

Wang

Chen

Xue

et al. 2021

Translational Oncology

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Highlights SDH mutations are responsible for the occurrence of head and neck paragangliomas (HNPGLs). Deregulation of oxidative phosphorylation (ROS) in association with metabolism may play an important role in HNPGLs. NDUFA 2, 4 and 10 showed the most significant deregulaion in HNPGLs, and this deregulation can be corrected by metformin. Metformin exerts inhibitory effects on HNPGL cells via reduced level of reactive oxygen species and altered metabolism. Proteomic/metabolic profiling of HNPGLs identifies the role of ROS/metabolism as a therapeutic target in clinical settings.

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“…Unmethylated profile is also known as hypomethylated. 11,12 they are interesting targets for the study of chemoinduced oral mucositis.…”

Section: Discussionmentioning

confidence: 99%

“…4,8 The genes that encode the antioxidant enzymes catalase and superoxide dismutase and the proinflammatory cytokines tumor necrosis factoralpha and interleukin-6, are regulated by epigenetic mechanisms and are associated with disease. [9][10][11][12] Epigenetics is information that is "above the DNA", which controls gene expression, and is both heritable and reversible. Epigenetic marks include DNA methylation, chemical changes in histones, and small non-coding RNAs.…”

Section: Introductionmentioning

confidence: 99%

TNF-α promoter hypomethylation is frequent in oncopediatric patients who recovered from mucositis

VIANA FILHO,

CASTRO COÊLHO,

QUEIROZ NETO

et al. 2024

Braz. oral res.

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The aim of this study was to investigate the DNA methylation profile in genes encoding catalase (CAT) and superoxide dismutase (SOD3) enzymes, which are involved in oxidative stress mechanisms, and in genes encoding pro-inflammatory cytokines interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-α) in the oral mucosa of oncopediatric patients treated with methotrexate (MTX ® ). This was a cross-sectional observational study and the population comprised healthy dental patients (n = 21) and those with hematological malignancies (n = 64) aged between 5 and 19 years. Oral conditions were evaluated using the Oral Assessment Guide and participants were divided into 4 groups: 1-healthy individuals; 2-oncopediatric patients without mucositis; 3-oncopediatric patients with mucositis; 4-oncopediatric patients who had recovered from mucositis. Methylation of DNA from oral mucosal cells was evaluated using the Methylation-Specific PCR technique (MSP). For CAT, the partially methylated profile was the most frequent and for SOD3 and IL6, the hypermethylated profile was the most frequent, with no differences between groups. For TNF-α, the hypomethylated profile was more frequent in the group of patients who had recovered from mucositis. It was concluded that the methylation profiles of CAT, SOD3, and IL6 are common profiles for oral cells of children and adolescents and have no association with oral mucositis or exposure to chemotherapy with MTX ® . Hypomethylation of TNF-α is associated with oral mucosal recovery in oncopediatric patients who developed oral mucositis during chemotherapy.

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Association ofSOD3 promoter DNA methylation with its down-regulation in breast carcinomas

Cited by 17 publications

References 37 publications

Impact of EcSOD Perturbations in Cancer Progression

Impact of EcSOD Perturbations in Cancer Progression

High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma

TNF-α promoter hypomethylation is frequent in oncopediatric patients who recovered from mucositis

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