Association study between glutathione S-transferase P1 polymorphism and schizophrenia in the Korean population

Pae, Chi‐Un; Kim, Jung-Jin; Lee, Soo-Jung; Lee, Chang-Uk; Lee, Chul; Paik, In‐Ho; Park, Ho-Ran; Yang, Soo Young; Serretti, Alessandro

doi:10.1016/s0278-5846(03)00043-5

Cited by 24 publications

(23 citation statements)

References 35 publications

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“…However, we did not find any association between GSTP1 polymorphisms and schizophrenia, probably because GSTP1 polymorphisms do not affect protein levels, but modulate GSTP1 affinity to its substrates. In accordance to our findings, it has been previously reported that GSTP1 polymorphisms do not confer susceptibility to schizophrenia (Pae et al, 2003).…”

Section: Discussionsupporting

confidence: 93%

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Gravina

Spoletini

Masini

et al. 2011

Psychiatry Research

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Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.

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Section: Discussionsupporting

confidence: 93%

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Gravina

Spoletini

Masini

et al. 2011

Psychiatry Research

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“…The prevalence of GSTP1 Val105 in the present study ranges from 20% to 38.2% which is slightly higher than the frequencies reported in other Asian Populations (Harris , 1998;Pae et al, 2003). A Lesser frequency of GSTP1 Val allele was also reported in Somalis (8%) (Buchard et al, 2007), sub-Saharan Africans (12 to 21%) (Dandara et al, 2002) and Arabs (13%) (Buchard et al, 2007).…”

Section: Discussioncontrasting

confidence: 55%

Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (Ile105Val) Polymorphisms among South Indian Populations

Lakkakula¹,

Maram²,

Gurramkonda³

et al. 2013

ACRT

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Background: Glutathione S-transferases (GSTs) are members of the phase II biotransformation enzymes that play a key role in cellular detoxification of chemical carcinogens and xenobiotics. Variations at GST genes have been reported in different human populations, and some association studies have reported increased risk for cancers and other disease end points. The present study was conducted to investigate the allele frequency variations in south Indian populations.

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“…Studies on European descendants in Australia, Caucasians in the United States, Portugal, France, and Spain found consistent genotype distributions of around 45%, 45%, and 10% for Ile/Ile, Ile/Val, and Val/Val, respectively (25 -29). On the other hand, our study and studies on Chinese populations in Shanghai and North China, as well as Korean population showed another pattern of genotype distribution, the frequencies of Ile/Ile, Ile/Val, and Val/Val were about 65%, 30%, and 5%, respectively (22,30,31).…”

Section: Gstp1polymorphism and Endometrial Carcinomamentioning

confidence: 51%

Single Nucleotide Polymorphism of Pi-Class Glutathione S-Transferase and Susceptibility to Endometrial Carcinoma

Chan¹,

Khoo²,

Ngan

et al. 2005

Clinical Cancer Research

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Purpose: Endometrial carcinoma is the most common gynecologic cancer in developed countries. Prolonged unopposed estrogen exposure has been identified as the major risk factor. The pi-class glutathione S-transferase (GSTP1) is a phase II metabolic enzyme that is important in the detoxification of a wide range of electrophiles including carcinogenic steroid-hormone intermediates generated through oxidative metabolism. In this study, we aimed at determining the association between the GSTP1 polymorphism and the risk of endometrial carcinoma in a Chinese population. Experimental Design: Genotyping of 180 cases and 200 age-matched controls were assessed by PCR-RFLP approach and confirmed by direct sequencing. Results: Statistical analysis showed that patients of valine allele carriers had 2.03-fold of increased risk of developing endometrial carcinoma (P < 0.01). The allele frequencies for the Ile and Val variants between the cancer cases and controls were also significantly different (P < 0.01; odds ratio, 1.59; 95% confidence interval, 1.13-2.23). Such association was shown in endometrial cancers as a group and in type I endometrioid adenocarcinoma but not the type II nonendometrioid adenocarcinoma. In addition, the Val allele was found significantly associated with high-grade endometrial cancer and/or endometrial cancer of deep myometrial invasion (P < 0.01). Interestingly, the relatively low frequency of Val/Val genotype in both the cancer cases and controls, in parallel with the lower incidence of endometrial cancer in Chinese, was observed when compared with those in Caucasians. Conclusions: Our findings suggested that the GSTP1 Ile 105 Val polymorphism was associated with an increased risk of endometrial cancer. Further studies may be required to explore the possible significance of these polymorphisms on GSTP1-related metabolism that may affect the susceptibility of Asians to endometrial carcinoma.

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Association study between glutathione S-transferase P1 polymorphism and schizophrenia in the Korean population

Cited by 24 publications

References 35 publications

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (Ile105Val) Polymorphisms among South Indian Populations

Single Nucleotide Polymorphism of Pi-Class Glutathione S-Transferase and Susceptibility to Endometrial Carcinoma

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