Association study between intestinal flora and renal malignancy based on genome-wide association analysis data

Abstract

Objective Gut microbiome (GM) plays an important role in a variety of diseases, and renal malignancies have been shown to be closely associated with GM. However, the role of GM in the pathogenesis of renal malignancies has not been fully explored. The aim of this study was to investigate the potential causal association between intestinal flora and renal malignancies and the possible mechanisms of action. Methods We collected genome-wide association study (GWAS) data on GM and renal malignancies and applied Mendelian randomization (MR) analysis to explore the causal association between them. Results By MR analysis, we found that GM components associated with renal malignancies, including enterobacteria of certain orders, families, and genera, may have negative causal effects in the pathogenesis, while enterobacteria of other orders, families, and genera may have positive causal associations with renal malignancies. Conclusion This study reveals a possible causal association between intestinal flora and renal malignancies and identifies several genetic variants involved in this association. These findings are expected to provide new insights into the pathogenesis of renal malignancies and provide a theoretical basis for the development of therapeutic strategies targeting intestinal flora in the future.