Association study between polymorphisms of dopamine transporter gene (SLC6A3), dopamine D1 receptor gene (DRD1), and autism

Azzam, Azza Abdel Aziz; Bahgat, Dina M. Rasheed; Shahin, Rasha Mohamad Hosny; Nasralla, Ranaih Massoud Azme

doi:10.4103/jmisr.jmisr_8_18

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that there was a correlation between DRD1 rs4532 polymorphism and autism among Egyptian population. The mother’s age at conception was also correlated with rs2550936 SNP at SLC6A3 [ 48 ]. Similarly, there was a significant association between rs2550936 A/C polymorphism of SLC6A3 and rs4532 A/G polymorphism of DRD1 with ASD in which the GA genotype of DRD1 and CA genotype of SLC6A3 can be risk factor of ASD in a subpopulation of Saudi patients [ 49 ].…”

Section: Transportersmentioning

confidence: 99%

See 1 more Smart Citation

Genetic and molecular biology of autism spectrum disorder among Middle East population: a review

et al. 2021

View full text Add to dashboard Cite

Background Autism spectrum disorder (ASD) is a neurodevelopmental disease, characterized by impaired social communication, executive dysfunction, and abnormal perceptual processing. It is more frequent among males. All of these clinical manifestations are associated with atypical neural development. Various genetic and environmental risk factors are involved in the etiology of autism. Genetic assessment is essential for the early detection and intervention which can improve social communications and reduce abnormal behaviors. Although, there is a noticeable ASD incidence in Middle East countries, there is still a lack of knowledge about the genetic and molecular biology of ASD among this population to introduce efficient diagnostic and prognostic methods. Main body In the present review, we have summarized all of the genes which have been associated with ASD progression among Middle East population. We have also categorized the reported genes based on their cell and molecular functions. Conclusions This review clarifies the genetic and molecular biology of ASD among Middle East population and paves the way of introducing an efficient population based panel of genetic markers for the early detection and management of ASD in Middle East countries.

show abstract

Section: Transportersmentioning

confidence: 99%

“…[ 47 ] 2015 DRD4 Egypt 178 patients 128 controls Polymorphisms were correlated with ASD. Azzam et al [ 48 ] 2018 SLC6A3 DRD1 Egypt 50 patients 50 controls SLC6A3 polymorphisms were correlated with mother’s age. DRD1 polymorphisms were correlated with age in ASD.…”

Section: Introductionmentioning

confidence: 99%

Genetic and molecular biology of autism spectrum disorder among Middle East population: a review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The dopamine transporter (DAT1) regulates and controls dopamine levels in the brain and among dopaminergic neurons in the synaptic cleft through the reuptake of DA in the presynaptic terminals [ 11 ]. The DAT1 gene, also called SLC6A3 , is located on chromosome 5p15.3 [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The 3′UTR VNTR SLC6A3 Genetic Variant and Major Depressive Disorder: A Systematic Review

et al. 2023

View full text Add to dashboard Cite

Major Depressive Disorder (MDD) is a disabling and particularly persistent mental disorder that is considered to be a priority public health problem. The active human dopamine transporter (DAT), which is encoded by the SLC6A3 gene, regulates the dopamine concentration in the synaptic cleft. In this sense, this neurotransmitter is primordial in modulating human emotions. This systematic review aims to verify the SLC6A3 (DAT1) 3′UTR VNTR (rs28363170) gene variant’s SS (9R/9R) genotype and S (9R) allele frequency fluctuation and its influence on the modulation of pharmacotherapy in MDD. For this purpose, we searched different databases, and after applying the eligibility criteria, six articles were selected. Studies have shown an association between the SS (9R/9R) genotypic and S (9R) allelic presence with the risk of developing MDD, in addition to influencing the decrease in response to antidepressant therapy. However, despite the findings, disagreements were observed between other studies. For this reason, further studies with the SLC6A3 3′UTR VNTR (rs28363170) variant in different populations are necessary to understand this polymorphism’s role in the onset of this disease.

show abstract

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism

Shilbayeh,

Adeen,

Alhazmi

et al. 2024

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Association study between polymorphisms of dopamine transporter gene (SLC6A3), dopamine D1 receptor gene (DRD1), and autism

Cited by 6 publications

References 0 publications

Genetic and molecular biology of autism spectrum disorder among Middle East population: a review

Genetic and molecular biology of autism spectrum disorder among Middle East population: a review

The 3′UTR VNTR SLC6A3 Genetic Variant and Major Depressive Disorder: A Systematic Review

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism

Contact Info

Product

Resources

About