Association Study between Psoriatic Arthritis and Killer Immunoglobulin-Like Receptor (<i>KIR</i>) Genes: A Meta-Analysis

Enciso-Vargas, Moisés; Alvarado-Ruíz, Liliana; Suárez-Villanueva, Alexis Sayuri; Macías-Barragán, José; Montoya‐Buelna, Margarita; Oceguera-Contreras, Edén; Alvarado-Navarro, Anabell; Graciano-Machuca, Omar

doi:10.1080/08820139.2020.1713145

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…It was shown that above forty genes especially HLA and KIR genes have a role in pathogenesis of psoriasis ( 324 ). KIR gene family may act as a potential susceptibility factor for psoriasis ( 325 ). It was reported that activating receptors KIR2DS1 and KIR2DS2 increased the risk of developing psoriatic arthritis (PsA), particularly inhibitor receptors KIR2DL1 and KIR2DL2/3 were missing ( 54 ).…”

Section: Natural Killer Maturation Phenotypes Distribution and Funcmentioning

confidence: 99%

“…Presence of KIR2DS1-HLA-C is a major risk factor for psoriasis ( 326 ). Meta-analysis studies indicated that KIR2DL2, KIR2DS1, KIR2DS2 and KIR2DS3 genes were positively associated with susceptibility to PsA ( 325 ), and KIR2DS4 and 3DL1 genes appear to confer protection ( 327 ). HLA-Cw6 was found to be associated with guttate psoriasis ( 328 , 329 ).…”

Section: Natural Killer Maturation Phenotypes Distribution and Funcmentioning

confidence: 99%

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The Role of Natural Killer Cells in Autoimmune Diseases

et al. 2021

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Natural killer (NK) cells, the large granular lymphocytes differentiated from the common lymphoid progenitors, were discovered in early 1970’s. They are members of innate immunity and were initially defined by their strong cytotoxicity against virus-infected cells and by their important effector functions in anti-tumoral immune responses. Nowadays, NK cells are classified among the recently discovered innate lymphoid cell subsets and have capacity to influence both innate and adaptive immune responses. Therefore, they can be considered as innate immune cells that stands between the innate and adaptive arms of immunity. NK cells don’t express T or B cell receptors and are recognized by absence of CD3. There are two major subgroups of NK cells according to their differential expression of CD16 and CD56. While CD16+CD56dim subset is best-known by their cytotoxic functions, CD16-CD56bright NK cell subset produces a bunch of cytokines comparable to CD4+ T helper cell subsets. Another subset of NK cells with production of interleukin (IL)-10 was named as NK regulatory cells, which has suppressive properties and could take part in immune-regulatory responses. Activation of NK cells is determined by a delicate balance of cell-surface receptors that have either activating or inhibitory properties. On the other hand, a variety of cytokines including IL-2, IL-12, IL-15, and IL-18 influence NK cell activity. NK-derived cytokines and their cytotoxic functions through induction of apoptosis take part in regulation of the immune responses and could contribute to the pathogenesis of many immune mediated diseases including ankylosing spondylitis, Behçet’s disease, multiple sclerosis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus and type-1 diabetes. Dysregulation of NK cells in autoimmune disorders may occur through multiple mechanisms. Thanks to the rapid developments in biotechnology, progressive research in immunology enables better characterization of cells and their delicate roles in the complex network of immunity. As NK cells stand in between innate and adaptive arms of immunity and “bridge” them, their contribution in inflammation and immune regulation deserves intense investigations. Better understanding of NK-cell biology and their contribution in both exacerbation and regulation of inflammatory disorders is a requisite for possible utilization of these multi-faceted cells in novel therapeutic interventions.

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Section: Natural Killer Maturation Phenotypes Distribution and Funcmentioning

confidence: 99%

Section: Natural Killer Maturation Phenotypes Distribution and Funcmentioning

confidence: 99%

The Role of Natural Killer Cells in Autoimmune Diseases

et al. 2021

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“…Briefly, HLA-Cw*01:02-binding peptides antagonize the inhibition mediated by KIR2DL2/KIR2DL3, leading to activation of NK cells [35]. In a meta-analysis of five articles, the KIR2DL2 polymorphism was significantly associated with psoriatic arthritis (odds ratio [OR] = 1.269, p = 0.003) [36]. Theoretically, the differences in HLA-Cw distribution may influence the clinical manifestations and types of trigger factors for psoriatic diseases [18,37].…”

Section: Role Of Hla-cw1 In the Immune Systemmentioning

confidence: 99%

HLA-Cw1 and Psoriasis

Huang

Tsai

2021

Am J Clin Dermatol

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Psoriasis is a chronic inflammatory skin condition with regional and ethnic differences in its prevalence and clinical manifestations. Human leukocyte antigen (HLA)-Cw6 is the disease allele conferring the greatest risk to psoriasis, but its prevalence is lower in Asian individuals. Recent studies have found associations between HLA-Cw1 and some Asian populations with psoriasis, especially Southern Chinese. HLA-Cw6 was associated with type I early-onset psoriasis, guttate psoriasis, Koebner phenomenon, and better response to methotrexate, interleukin (IL)-12/23, IL-17, and IL-23 targeting drugs. In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial type of psoriatic arthritis. Furthermore, HLA-Cw1 was more frequently associated with high-need patients who did not respond to conventional therapies. No known trigger factor nor autoantigen has been identified for HLA-Cw1 positivity. However, HLA-Cw1 has been linked to some viral agents. For example, cytotoxic T lymphocytes recognize multiple cytomegalovirus pp65-derived epitopes presented by HLA alleles, including HLA-C*01:02. In addition, cytomegalovirus can lead to severe exacerbation of psoriatic skin disease. The proposed interaction between viral infection, HLA-Cw1, and psoriasis is through the killer cell immunoglobulin-like receptors of natural killer cells. Given the diverse nature of psoriasis pathogenesis and the difference in HLA-Cw prevalence in different racial groups, more studies are needed to confirm the role of HLA-Cw1 in psoriasis. Key PointsHuman leukocyte antigen (HLA)-Cw1 is a less recognized but important HLA-Cw allele associated with psoriasis in some Asian ethnicities.Patients carrying HLA-Cw1 tend to show higher disease activity, have an increased risk of developing erythrodermic psoriasis, and are more refractory to treatments.

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“…Similarly, a study conducted in the European population in 2012 by Chen et al found an association between KIR3DS1 gene presence and PsV susceptibility (SP = 46.6% vs. HS = 32.6%, p < 0.001) [29]. The KIR3DS1 gene has also been associated with susceptibility to psoriatic arthritis, a seronegative spondyloarthropathy related to psoriasis disease [30]. In contrast to our results, studies in Japanese, Polish, American, Swedish, and Brazilian populations have shown a positive association mainly with the KIR2DS1 gene [12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 84%

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

Graciano-Machuca

Alvarado-Navarro

Ramírez‐Dueñas

et al. 2020

Genes

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NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1/HLA-ABw4 (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1/HLA-Bw4Ile80 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1/HLA-ABw4 genotype in PsV pathology.

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Association Study between Psoriatic Arthritis and Killer Immunoglobulin-Like Receptor (KIR) Genes: A Meta-Analysis

Cited by 11 publications

References 35 publications

The Role of Natural Killer Cells in Autoimmune Diseases

The Role of Natural Killer Cells in Autoimmune Diseases

HLA-Cw1 and Psoriasis

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

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