Association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with diabetes mellitus type 2 and distal diabetic polyneuropathy

Abstract

Even with long‑term glycemic control, diabetes mellitus type 2 (DM2) remains the predominant cause of diabetic neuropathy. Single nucleotide polymorphism (SNP) C936T of the vascular endothelial growth factor (VEGF) gene and the SNP C242T of the p22phox (CYBA) gene have been investigated in relation to DM2 and its complications. The aim of the present study was to investigate the association between these two SNPs and DM2, and also between the SNPs and the signs and symptoms of diabetic distal polyneuropathy. The DM2 group consisted of 98 individuals and the control group consisted of 104 individuals. The results demonstrated that there was no association between the different genotypes or alleles and increased risk of the disease (P>0.05). With SNP C242T, a significant association with body mass index between the CTxTT genotypes (P=0.043) was identified; and the greatest body mass indexes were among individuals with the TT genotype. An association between the degree of neuropathic symptoms and genotypic/allelic distribution of these polymorphisms was not observed. In conclusion, the investigated polymorphisms are not correlated with the risk of developing DM2.

Association between VEGF genetic variants and diabetic foot ulcer in Chinese Han population

“…It had been reported that VEGF gene polymorphisms were associated with T2DM, as well as its complications. [ 31 ]…”

Relationship of Heavy Metal in Diabetes and Non-Diabetic Foot Ulcer Patients.

“…magnesium) are known as macro-metals and are found in high amount in the body tissues, therefore they are also called macro-nutrients. 10 At least 100 mg of each macro-nutrient is required in the daily diet 11 . In contrast, some metals e.g.…”

Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review

“…In the early stages of DPN, abnormalities in the vasa nervorum and loss of nerve fibers can be seen in association with hyperglycemia. Damage to the nervous tissue results in increased intravascular endothelial growth factor ( VEGF ) plasma levels in diabetic animal models [ 52 ]. The ischemia and hypoxia in the nerves of patients with T2D due to microangiopathy of vasa nervorum have always been observed and may be a key pathogenic mechanism of DPN [ 53 ].…”

“…The ischemia and hypoxia in the nerves of patients with T2D due to microangiopathy of vasa nervorum have always been observed and may be a key pathogenic mechanism of DPN [ 53 ]. An association study by Ghisleni et al showed a clear association between diabetic polyneuropathy and the C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox allele of CYBA gene [ 52 ].…”

“…An association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with T2D and DPN in a population of Caucasian ethnicity was studied by Ghisleni et al According to their results, the C936T polymorphism of the VEGF gene and C242T polymorphism of the p22phox gene did not correlate with the risk of developing diabetes mellitus or neuropathic signs and symptoms. When considering the results of other studies, a substantial heterogeneity in the findings is observed, which demonstrates a complex link between the risk factors of DM and genetic predisposition to DPN [ 52 ]. Common susceptible and prognostic genetic factors associated with DPN in T2D are diverse in different pathophysiological pathways, and it is difficult to separate each genetic variant from the other as most of the variants are interrelated with each other ( Table 1 ).…”