Association Study of CD14 Polymorphism With Myocardial Infarction in a Japanese Population

Hohda, Shigeru; Kimura, Akinori; Sasaoka, Taishi; Hayashi, Takeharu; Ueda, Kazuo; Yasunami, Michio; Okabe, Masaru; Fukuta, Naoto; Kurosawa, Toshiro; Izumi, Tohru

doi:10.1536/jhj.44.613

Cited by 34 publications

(35 citation statements)

References 33 publications

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“…The diagnosis of CAD was based on the standard criteria as described earlier. 10 Severity of coronary atherosclerosis was classified according to the number of coronary vessels with significant stenosis (angiographic luminal stenosis 450%) as 0, 1, 2 or 3 vessel disease. Informed consent was given from each participant and the study was approved by the Ethics Review Boards of Medical Research Institute of Tokyo Medical and Dental University, Kitasato University School of Medicine, Tokyo Metropolitan Geriatric Medical Center and Samsung Medical Center.…”

Section: Materials and Methods Subjectsmentioning

confidence: 99%

Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations

et al. 2009

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Coronary artery disease (CAD) has become a major health problem in many countries because of its increasing prevalence and high mortality. Recently, an association of a functional sequence variation, À8C4G, in the human proteasome subunit a type 6 gene (PSMA6) with the susceptibility to CAD was reported. To validate the association, we investigated a total of 1330 cases and 2554 controls from Japanese and Korean populations for PSMA6 genotypes, and no evidence of the association was obtained in both Japanese (odds ratio (OR)¼1.03, 95% confidence interval (CI); 0.90-1.19, P¼0.66, allele count model) and Korean populations (OR¼1.00, 95% CI; 0.86-1.17, P¼0.95, allele count model). However, when a meta-analysis of data from this study and previously reported six replication studies was done, OR was 1.08 for the G allele (95% CI; 1.02-1.14, P¼0.0057), suggesting that the contribution of PSMA6 to CAD was not large enough to be readily replicated. Further studies are required to establish the contribution of this variant in the susceptibility to CAD.

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Section: Materials and Methods Subjectsmentioning

confidence: 99%

Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations

et al. 2009

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“…The diagnosis of CAD was based on the standard criteria as described earlier. 9 Severity of coronary atherosclerosis was classified according to the number of coronary vessels with significant stenosis (angiographic luminal stenosis 450%) as 0, 1, 2 or 3 vessel disease, as described earlier. 10 Informed consent was given from each participant and the study was approved by the Ethics Review Boards of Medical Research Institute of Tokyo Medical and Dental University, Kitasato University School of Medicine, Tokyo Metropolitan Geriatric Medical Center and Samsung Medical Center.…”

Section: Methods Subjectsmentioning

confidence: 99%

Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations

et al. 2009

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Coronary artery disease (CAD) and stroke are the major health problems in many countries because of their increasing prevalence and high mortality. It is well known that CAD and stroke are based on atherosclerosis and shared environmental and genetic risk factors. Recently, an association of a functional sequence variation À154G4A in the angiotensin receptor-like 1 (AGTRL1) with a susceptibility to stroke was reported. In this study, we investigated a total of 1479 CAD cases and 2062 controls from the Japanese and Korean populations to validate the association of AGTRL1 with CAD. However, we obtained no evidence of the association in both the Japanese (odds ratio (OR)¼0.95, 95% confidence interval (CI); 0.82-1.10, P¼0.47, allele count model) and Korean (OR¼0.90, 95% CI; 0.77-1.05, P¼0.18, allele count model) populations. In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that AGTRL1 did not contribute much to the atherosclerosis of the coronary artery. Keywords: coronary artery disease; AGTRL1; single nucleotide polymorphism; case-control study INTRODUCTIONCoronary artery disease (CAD) is caused by the thrombotic occlusion of coronary arteries and becomes a major health problem in many countries. CAD is mainly based on the atherosclerosis of the coronary artery and often manifests with sudden chest pain because of reversible (angina pectoris, AP) or irreversible (myocardial infarction, MI) ischemia in the heart caused by the decreased blood flow in the coronary arteries.Stroke, in particular, ischemic stroke is caused by the thrombotic occlusion of cerebral arteries associated with atherosclerosis, which shares at least in part pathogenic mechanisms and risk factors such as smoking, hypertension, hypercholesterolemia and diabetes mellitus with CAD, 1 and recent genome-wide association studies have identified polymorphism on chromosome 9p21 as a common risk variant for both stroke and CAD. [2][3][4] In addition, Hata et al. 5 recently reported that angiotensin receptor-like 1 (AGTRL1) was highly expressed in the cardiovascular system and the central nervous system and that a functional sequence variation À154G4A (rs9943582) in the 5¢-anking region of AGTRL1 was associated with the stroke in Japanese; the G allele frequencies were 0.721 and 0.666 in patients and controls, respectively (OR¼1.30, 95% CI; 1.14-1.47, P¼6.6Â10 À5 ).

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“…Korean control subjects were randomly selected from healthy individuals (n = 182) and cancer patients (n = 524) without a history of CAD. The diagnosis of CAD and classical risk factors was based on the standard criteria as described previously (Hohda et al 2003). Severity of coronary atherosclerosis was classified according to the number of coronary vessels with significant stenosis (angiographic luminal stenosis[50%) as one-, two-, or three-vessel disease (VD).…”

Section: Subjectsmentioning

confidence: 99%

Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations

et al. 2008

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Coronary artery disease (CAD) has become a major health problem in many countries. Recent genomewide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR) = 1.30, 95% confidence interval (CI); 1.13-1.49, p = 0.00027, allele count model] and Koreans (OR = 1.19, 95% CI; 1.02-1.38, p = 0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.

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Association Study of CD14 Polymorphism With Myocardial Infarction in a Japanese Population

Cited by 34 publications

References 33 publications

Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations

Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations

Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations

Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations

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