Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts

Vaquero-Lorenzo, Concepción; Baca‐García, Enrique; Díaz-Hernández, Montserrat; Perez‐Rodriguez, M. Mercedes; Fernández-Navarro, Pablo; Giner, Lucas; Carballo, Juan J.; Sáiz-Ruiz, Jerónimo; Fernández‐Piqueras, José; Baldomero, Enrique Baca; Leon, José de; Oquendo, María A.

doi:10.1002/ajmg.b.30642

Cited by 29 publications

(16 citation statements)

References 29 publications

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“…Among females, there was a linear dose effect of 102T>C, suggesting that C/C females had a higher negativity bias compared to females carrying a T allele, with the largest difference between C/C and T/T homozygotes. The C/C genotype has been associated with affect regulation, including the development of depression (Jokela et al, 2007), schizophrenia (Abdolmaleky, Faraone, Glatt, & Tsuang, 2004), suicide attempts (Vaquero-Lorenzo et al, 2008), and anxietyrelated traits (Golimbet, Alfimova, & Mityushina, 2004). Interestingly, rs6311, a functional variant in almost perfect LD with 102T>C, is associated with obsessive compulsive disorder and eating disorders, but only in females (for a review, see Norton & Owen, 2005).…”

Section: Discussionmentioning

confidence: 99%

Individual differences in positivity offset and negativity bias: Gender-specific associations with two serotonin receptor genes

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Norris

Wileyto

et al. 2013

Personality and Individual Differences

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Individual differences in the evaluation of affective stimuli, such as the positivity offset and negativity bias may have a biological basis. We tested whether two SNPs (HTR2A; 102T>C and HTR1A; 1019C>G) related to serotonin receptor function, a biological pathway associated with affective regulation, were differentially related to positivity offset and negativity bias for males and females. Participants were 109 cigarette smokers who rated a series of affective stimuli to assess reactions to positive and negative pictures. Gender × genotype interactions were found for both SNPs. Males with the 102T allele showed a greater positivity offset than males with the 102C allele. For females, in contrast, the 1019C allele was associated with a greater positivity offset than the 1019G allele, whereas the 102T allele was associated with a greater negativity bias than the 102C allele. Identifying how gender differences may moderate the effect of serotonin receptor genes on affective information processing may provide insight into their role in guiding behavior and regulating affect.

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Section: Discussionmentioning

confidence: 99%

Individual differences in positivity offset and negativity bias: Gender-specific associations with two serotonin receptor genes

Ashare

Norris

Wileyto

et al. 2013

Personality and Individual Differences

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“…Case and control ascertainment and clinical evaluations were standardized between sites as described previously (Baca-Garcia, Oquendo, Saiz-Ruiz, Mann, & de Leon, 2006). Genetic data from subsets of these research participants have been used in previous studies with different research objectives (Almoguera et al, 2011; Almoguera et al, 2013a, 2013b; Alonso et al, 2008; Baca-Garcia et al, 2005; Baca-Garcia et al, 2003; Baca-Garcia, Vaquero, Diaz-Sastre, Garcia-Resa, et al, 2004; Baca-Garcia, Vaquero, Diaz-Sastre, Jimenez-Trevino, et al, 2004; Baca-Garcia et al, 2002; Baca-Garcia et al, 2007; Baca-Garcia et al, 2010; Bermudo-Soriano et al, 2009; Blasco-Fontecilla et al, 2013; Costas et al, 2010; Fernandez-Navarro et al, 2012; Gratacos et al, 2009; Lopez-Castroman et al, 2009; Lorenzo et al, 2007; Penas-Lledo et al, 2012; Perroud et al, 2010; Sublette et al, 2008; Vaquero et al, 2004; Vaquero Lorenzo et al, 2006; Vaquero-Lorenzo et al, 2008; Vaquero-Lorenzo et al, 2014; Vaquero-Lorenzo et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior

Sublette

Vaquero

Baca‐García

et al. 2016

Psychiatric Genetics

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Fatty acid desaturase genes (FADS1-FADS2) encode for desaturases participating in biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Since LC-PUFAs are implicated in major depressive disorder (MDD) and suicide risk, and both are partly heritable, we studied the association of FADS1-FADS2 polymorphisms with MDD (635 cases, 480 controls), and suicide attempt status (291 attempters, 338 non-attempters).. Eighteen FADS-related single-nucleotide polymorphisms (SNPs) were genotyped from Caucasians enrolled in Madrid (n=791) or New York City (n=324), and entered as predictors into logistic regression analyses with diagnostic group or suicide attempt history as outcomes, and covariates location and sex. No associations were observed between any SNPs and diagnosis or attempt status. As statistical power was adequate, we conclude that FADS1-FADS2 genetic variants may not be a common determinant of MDD.

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“…10 There is no clear association with this polymorphism and depression, 11,12 schizophrenia 13 or bipolar affective disorder, 14 and also no association has been found with suicidal behaviour or ideation. [15][16][17][18] However, this polymorphism has been shown to have an association with treatment outcomes following treatment with clozapine, which modifies serotonergic activity in the brain, 19 and the 5-HT 2A polymorphism has also been investigated for a possible role in antidepressant treatment outcomes, but results to date have shown only marginal significance or no association. 11,20,21 These polymorphisms may also be associated with the severity of adverse effects from the SSRI group of antidepressant medications.…”

Section: Introductionmentioning

confidence: 94%

Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT2A receptor

et al. 2014

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Serotonin toxicity results from serotonin excess in the central nervous system from serotonergic drugs. Previous studies suggest an association between T102C polymorphism of the serotonin 2A (5-hydroxytryptamine 2A) receptor gene and serotonergic adverse effects with serotonergic drugs. We aimed to determine whether there is an association between the T102C polymorphism and serotonin toxicity in patients taking serotonergic drug overdoses. Ninety-five patients presenting with serotonergic drug overdoses were examined for serotonin toxicity and had blood collected for DNA analysis. A diagnosis of serotonin toxicity was made in 14 patients (15%) based on the Hunter Serotonin Toxicology Criteria. Four of the 14 patients (29%) with serotonin toxicity had the C/C genotype compared with 20/81 (25%) without serotonin toxicity. There were no differences in age or sex, but the median defined daily dose taken by patients with serotonin toxicity was 27 (14-84) compared with 18 (2-136) in patients without serotonin toxicity (P=0.06). There was no association between serotonin toxicity and the T102C polymorphism in patients taking a serotonergic drug overdose.

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Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts

Cited by 29 publications

References 29 publications

Individual differences in positivity offset and negativity bias: Gender-specific associations with two serotonin receptor genes

Individual differences in positivity offset and negativity bias: Gender-specific associations with two serotonin receptor genes

Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior

Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT2A receptor

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