Associations among central nervous system serotonergic function and neuroticism are moderated by gender

Brummett, Beverly H.; Boyle, Stephen H.; Kuhn, Cynthia M.; Siegler, Ilene C.; Williams, Redford B.

doi:10.1016/j.biopsycho.2008.03.002

Cited by 22 publications

(17 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that the serotonin system in men and women act differently in important ways (Biver et al 1996;Brummett et al 2008a;Costes et al 2005;Kornstein et al 2001;Nishizawa et al 1997;Williams et al 2003). Moreover, the 5HTTLPR genotype has different implications for personality traits and emotional well-being depending on sex (Brummett et al 2008c;Dragan and Oniszczenko 2006;Walderhaug et al 2007).…”

Section: Discussionmentioning

confidence: 89%

Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study

et al. 2009

View full text Add to dashboard Cite

Serotonin plays a central role in mood regulation and the development of depressive disorders. The present study investigated whether a functional polymorphism (5HTTLPR) of the serotonin transporter gene interacts with maltreatment in the prediction of depression. A cohort of 17-18 years old students (n = 1,482) anonymously completed the Survey of Adolescent Life and Health in Vestmanland 2006 and gave a saliva sample for DNA extraction. An association between maltreatment and adolescent depression was found independent of sex. When the whole population was analyzed, no main effect of 5HTTLPR in association with depression was found. When separated by sex, a significant main effect and a G x E interaction effect of the SS allele was found among girls. No gene main effect or G x E interaction effect was found among boys. The present study confirms previous findings of sex differences in interaction effects between the 5HTTLPR polymorphism and maltreatment in the prediction of adolescent depression.

show abstract

Section: Discussionmentioning

confidence: 89%

Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study

et al. 2009

View full text Add to dashboard Cite

show abstract

“…This neurobiological model of personality, based on the big five, links the metatrait stability (combination of neuroticism reversed, agreeableness, and conscientiousness) with variability in serotonergic function, and the metatrait plasticity (combination of extraversion and openness) with variability in dopaminergic function. Brummett et al (2008) found that high serotonergic function was linked with lower levels of neuroticism in healthy females. In a non-clinical sample, Manuck et al (1998) showed that in males, neuroticism and conscientiousness were related, negatively and positively, with high serotonergic function.…”

Section: Discussionmentioning

confidence: 97%

Relationship between Circadian Typology and Big Five Personality Domains

Tonetti

Fabbri

Natale

2009

Chronobiology International

155

110

View full text Add to dashboard Cite

We explored the relationship between personality, based on the five-factor model, and circadian preference. To this end, 503 participants (280 females, 223 males) were administered the Morningness-Eveningness Questionnaire (MEQ) and the self-report version of the Big Five Observer (BFO) to determine circadian preference and personality features, respectively. Morning types scored significantly higher than evening and intermediate types on the conscientiousness factor. Evening types were found to be more neurotic than morning types. With reference to the big five personality model, our data, together with those of all the previous studies, indicate that the conscientiousness domain is the one that best discriminates among the three circadian types. Results are discussed with reference to neurobiological models of personality.

show abstract

“…Few serotonergic challenge-studies have reported data regarding traits of positive emotionality (i.e., extraversion), most of which have not shown a link between extraversion and serotonergic responsivity using different substances (e.g., Manuck et al, 1998; Flory et al, 2004; Brummett et al, 2008; Kuepper et al, 2010). Indeed, Reist et al (1996) demonstrated a positive association of the cortisol response to paroxetin (indicating a diminished serotonergic responsivity) in healthy males.…”

Section: Introductionmentioning

confidence: 99%

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality—the moderating role of the 5-HTTLPR

Wielpuetz¹,

Kuepper²,

Grant³

et al. 2013

Front. Hum. Neurosci.

View full text Add to dashboard Cite

According to the idea that the central serotonergic system has a modulatory function on behavior and personality in general, we aimed to highlight its association to habitual positive emotionality. In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality. Regression analyses revealed an involvement of the serotonergic system in positive emotionality. There was, however, no direct association between positive emotionality and cortisol responses to S-citalopram; rather 5-HTTLPR-genotype showed an association (p < 0.05). That is, positive emotionality scores increased with the number of s-alleles carried by the individuals. Most notable was the moderating role of 5-HTTLPR-genotype (p < 0.05) on the association between acute serotonergic responsivity and positive emotionality. Indeed, this association was only found in ss-homozygotes, in which the acute responsivity of the serotonergic system additionally seems to contribute to the level of positive emotionality (r = 0.70, p < 0.05). The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity—supporting the assumption of its valence-neutrality. In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development. They also indicate the need for further studies in order to clearly elucidate the role of the serotonergic system and its subcomponents in the regulation of positive emotionality.

show abstract

Associations among central nervous system serotonergic function and neuroticism are moderated by gender

Cited by 22 publications

References 39 publications

Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study

Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study

Relationship between Circadian Typology and Big Five Personality Domains

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality—the moderating role of the 5-HTTLPR

Contact Info

Product

Resources

About