Associations among Metabolic Syndrome, Ischemia, Inflammatory, Oxidatives, and Lipids Biomarkers

Gottlieb, Maria Gabriela Valle; Cruz, Ivana Beatrice Mânica da; Duarte, Marta Medeiros Frescura; Moresco, Rafael Noal; Wiehe, Mário; Schwanke, Carla Helena Augustin; Bodanese, Luiz Carlos

doi:10.1210/jc.2009-1592

Cited by 79 publications

(50 citation statements)

References 31 publications

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“…Since other diseases that are closely associated with changes in serum lipids also appear to demonstrate increased IMA (e.g., metabolic syndrome and obesity), there may be a specific link between these features in causing disease (13,14). This observation is emphasized by the fact that patients with pure hypercholesterolemia have increased IMA (12).…”

Section: Discussionmentioning

confidence: 99%

“…Individuals with hypercholesterolemia demonstrate increased IMA in addition to increased low-density lipoproteins (LDL) (12). Similarly, in cases of obesity or metabolic syndrome, an altered lipid metabolism and an increased IMA are often observed together (13,14). Notably, ACVD patients have been known to exhibit complications of abnormal lipid metabolism (15).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

et al. 2012

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Abstract. Acute cerebrovascular disease (ACVD) is associated with high morbidity and mortality rates, however, molecular markers to aid in its early detection are lacking. In this study, we examined the correlation between serum ischemia-modified albumin (IMA), a marker used to identify ischemic events in the heart, and blood lipids in patients with ACVD. Serum IMA levels were determined by enzyme-linked immuno sorbent assay, and total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein cholesterol (HDL) and triglyceride (TG) levels were determined biochemically in 62 patients with cerebral infarction (CI), 40 patients with intracerebral hemorrhage (ICH), 18 patients with subarachnoid hemorrhage (SAH) and 100 healthy individuals (controls). Serum IMA levels were significantly higher in each of the ACVD groups compared to the control group (CI, 80.81±11.97 U/ml; ICH, 80.25±10.91 U/ml; SAH, 74.43±11.39 U/ml and control, 41.08±5.10 U/ml; P<0.05). Additionally, serum TC, LDL and TG levels significantly increased, while serum HDL significantly decreased in the ACVD groups compared to the control group (P<0.05). A positive correlation was found between serum IMA levels and serum TC, LDL and TG levels in the ACVD patients, while serum IMA levels were negatively correlated with serum HDL levels (P<0.05). Thus, serum IMA increased following an ACVD event and was closely correlated with changes in the blood lipid levels. These factors, when combined, may allow the development of molecular markers for an earlier diagnosis of ACVD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

et al. 2012

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“…IMA is currently used as an early marker for myocardial ischemia and acute coronary syndrome [16]. It is also increased in diabetes mellitus, hyperlipidemia, chronic renal disease and obesity [17][18][19][20]. The constriction of vessels due to atherosclerotic lesions causes hypoxia/ischemia and oxidative changes resulting in transformation of free albumin to IMA in the circulation [21,22].…”

Section: Introductionmentioning

confidence: 99%

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

et al. 2017

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Background: Ischemia-modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress and an independent predictor of major adverse cardiovascular events. Objectives: To measure the levels of IMA in 45 children and adolescents with β-thalassemia major (β-TM) compared with 30 healthy controls and assess its relation to lipid peroxidation, vascular complications and subclinical atherosclerosis. Methods: β-TM patients without symptoms of heart disease were studied focusing on transfusion history, chelation therapy, serum ferritin, malondialdehyde (MDA) and IMA levels. Echocardiography was performed and carotid intima media thickness (CIMT) was assessed. Results: IMA and MDA levels were significantly higher in β-TM patients compared with controls (p < 0.001). IMA was higher among patients with heart disease, pulmonary hypertension risk and serum ferritin ≥2500 µg/l than those without. TM patients compliant to chelation had significantly lower IMA levels. IMA levels were positively correlated to MDA and CIMT while negatively correlated to ejection fraction and fractional shortening. Conclusion: Our results highlight the role of oxidative stress in the pathophysiology of vascular complications in thalassemia. IMA could be useful for screening of β-TM patients at risk of cardiopulmonary complications and atherosclerosis because its alteration occurs in early subclinical disease.

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“…Sinha et al (28) reported that IMA might be used for the early diagnosis of acute coronary syndrome. In another study, Valle Gottlieb et al (29) found significantly higher IMA values in patients with metabolic syndrome compared with a control group. Mentese et al (30) reported that IMA was an appropriate ischaemiareperfusion injury marker of testicular damage during acute and chronic periods.…”

Section: Discussionmentioning

confidence: 89%

Resveratrol Attenuates Both Small Bowel and Liver Changes in Obstructive Jaundice

et al. 2014

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Associations among Metabolic Syndrome, Ischemia, Inflammatory, Oxidatives, and Lipids Biomarkers

Abstract: We found an association between IMA and MS. Additional studies including prospective genetic variation approaches need to be performed to help elucidate this association between IMA and MS and its potential clinical role.

Cited by 79 publications

References 31 publications

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

Resveratrol Attenuates Both Small Bowel and Liver Changes in Obstructive Jaundice

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