Associations Among Sleep Latency, Subjective Pain, and Thermal Pain Sensitivity in Gynecologic Cancer

Abstract

Objective Pain is common among women with gynecologic cancer and contributes to depressed mood, sleep disturbances, and likelihood of future chronic pain. Little is known about how psychosocial factors are associated with central sensitization of pain in gynecologic cancer. This study examined relations among depressive symptoms, sleep, subjective pain, and aftersensation pain (a proxy for central sensitization of pain) in gynecologic cancer. Methods Participants were 42 women (mean age [SD] = 59.60 [10.11] years) enrolled in a randomized clinical trial examining psychological intervention effects on sleep, pain, mood, and stress hormones/cytokines in gynecologic cancer. Six to eight weeks after surgery, participants completed an assessment of depressive symptoms, sleep, and subjective pain and a temporal summation of pain protocol via quantitative sensory testing (QST). Results Controlling for recent chemotherapy, history of chronic pain, and analgesic medication use, regression analyses revealed that longer sleep onset latency (SOL; B = 3.112, P = 0.039, bias-corrected and accelerated (BCa) 95% confidence interval [CI] = 0.371 to 6.014) and greater sensory pain (B = 0.695, P = 0.023, BCa 95% CI = 0.085 to 1.210) were associated with greater aftersensation pain at 15 seconds. Greater sensory pain scores were associated with greater aftersensation pain at 30 seconds (B = 0.286, P = 0.045, BCa 95% CI = 0.008 to 0.513). Depression was not associated with aftersensation pain. The overall models accounted for 44.5% and 40.4% of the variance in aftersensation pain at 15 and 30 seconds, respectively. Conclusions. Longer SOL and higher subjective sensory pain were related to greater aftersensation of experimentally induced pain in women postsurgery for gynecologic cancers. Interventions that improve sleep and subjective sensory pain during the perisurgical period may reduce risk for central sensitization of pain.

The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19

“…Chronic pain and discomfort in DED may cause central sensitization, a common feature of patients with chronic pain; central sensitization is related to the plasticity of the central nervous system (51), a process in which the nervous system's response is progressively enhanced (52), eventually leading to pain despite low levels of peripheral stimulation. This pain response further prolongs sleep latency and ultimately triggers negative mood, anxiety, depressive symptoms in patients, as has been demonstrated in several studies including breast cancer patients (53). During the COVID-19, people were isolated at home and their use of visual display terminal (VDT) devices increased (54).Increased use of VDT can cause many physical discomforts, such as eye strain, musculoskeletal symptoms, headaches, and sleep problem (55).…”

Qualidade de sono, nível de sonolência e suas relações com indicadores de obesidade em pilotos militares brasileiros

“…Essa medida pode contribuir para avaliação da sonolência e restrição/privação de sono, visto que valores abaixo de cinco minutos indicam restrição/privação de sono severa; de cinco a dez minutos, um caso problemático; de dez a 15 minutos, um caso leve e de 15 a 20 minutos, pequeno ou nenhum débito de sono (JUNG et al, 2013). De maneira contrária, uma incapacidade de dormir em até 30 minutos pode significar uma latência de sono prolongada (KIRSCH et al, 2020). No nosso estudo, o tempo médio de latência de sono foi de 25,02 ± 22,54 minutos, sendo relatado tempo de latência mínimo de cinco e no máximo 120 minutos.…”

Pre-Diagnosis Sleep Status and Survival after a Diagnosis of Ovarian Cancer: A Prospective Cohort Study

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