Associations and pathways between residential greenness and hyperuricemia among adults in rural and urban China

Wang, Qinjian; Duojizhuoma,; Feng, Chuanteng; Teng, Fei; Ma, Hua; Wang, Songmei; Cirenwangla,; Yang, Tingting; Ling, Hua; Ma, Bangjing; Yu, Wanqi; Liu, Hongyun; Zhou, Jiming; Zhao, Xing; Jia, Peng

doi:10.1016/j.envres.2022.114406

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…Compared to urban greenspaces (e.g., parks, gardens, and greenways), greenspaces in rural areas may be undeveloped or inadequately equipped (e.g., natural forests) and not suitable for social activities. 74 In addition, it may also be related to urbanization and population density. With higher population densities in urban areas, city residents are more likely to have contact with neighbors and friends, which is beneficial for their mental health.…”

Section: Discussionmentioning

confidence: 99%

Association of Residential Greenness Exposure with Depression Incidence in Adults 50 Years of Age and Older: Findings from the Cohort Study on Global AGEing and Adult Health (SAGE) in China

Chen,

Wu,

Shi

et al. 2024

Environ Health Perspect

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Section: Discussionmentioning

confidence: 99%

Association of Residential Greenness Exposure with Depression Incidence in Adults 50 Years of Age and Older: Findings from the Cohort Study on Global AGEing and Adult Health (SAGE) in China

Chen,

Wu,

Shi

et al. 2024

Environ Health Perspect

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“…They can be comprehensively monitored using remote sensing technology, utilizing sensors aboard satellites for broad environmental surveillance globally. Direct measurement or straightforward calculation of certain environmental variables is possible using spectral information obtained from these sensors ( 17 – 19 ). For instance, airborne sensors on aircraft and unmanned aerial vehicles, such as drones, can directly capture urban built environment features including building outlines, road widths, and traffic density ( 20 – 21 ).…”

Section: Technology-based Data Collection and Simulation Methodsmentioning

confidence: 99%

State of the Art of Lifecourse Cohort Establishment

Dai,

Qiu,

et al. 2024

China CDC Weekly

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“…At present, there are approximately 120 million patients with HUA in China, of whom about 95% are male; it affects younger patients at an increasing rate. HUA has become one of the most life-threatening diseases in the world [5].…”

Section: Introductionmentioning

confidence: 99%

Hesperitin-Copper(II) Complex Regulates the NLRP3 Pathway and Attenuates Hyperuricemia and Renal Inflammation

Peng,

Liu,

et al. 2024

Foods

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Background: Hyperuricaemia (HUA) is a disorder of purine metabolism in the body. We previously synthesized a hesperitin (Hsp)-Cu(II) complex and found that the complex possessed strong uric acid (UA)-reducing activity in vitro. In this study we further explored the complex’s UA-lowering and nephroprotective effects in vivo. Methods: A mouse with HUA was used to investigate the complex’s hypouricemic and nephroprotective effects via biochemical analysis, RT-PCR, and Western blot. Results: Hsp-Cu(II) complex markedly decreased the serum UA level and restored kidney tissue damage to normal in HUA mice. Meanwhile, the complex inhibited liver adenosine deaminase (ADA) and xanthine oxidase (XO) activities to reduce UA synthesis and modulated the protein expression of urate transporters to promote UA excretion. Hsp-Cu(II) treatment significantly suppressed oxidative stress and inflammatory in the kidney, reduced the contents of cytokines and inhibited the activation of the nucleotide-binding oligomerization domain (NOD)-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory pathway. Conclusions: Hsp-Cu(II) complex reduced serum UA and protected kidneys from renal inflammatory damage and oxidative stress by modulating the NLRP3 pathway. Hsp-Cu(II) complex may be a promising dietary supplement or nutraceutical for the therapy of hyperuricemia.

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Associations and pathways between residential greenness and hyperuricemia among adults in rural and urban China

Cited by 7 publications

References 56 publications

Association of Residential Greenness Exposure with Depression Incidence in Adults 50 Years of Age and Older: Findings from the Cohort Study on Global AGEing and Adult Health (SAGE) in China

Association of Residential Greenness Exposure with Depression Incidence in Adults 50 Years of Age and Older: Findings from the Cohort Study on Global AGEing and Adult Health (SAGE) in China

State of the Art of Lifecourse Cohort Establishment

Hesperitin-Copper(II) Complex Regulates the NLRP3 Pathway and Attenuates Hyperuricemia and Renal Inflammation

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