Associations between air pollution and psychiatric symptoms in the Normative Aging Study

Qiu, Xinye; Danesh-Yazdi, Mahdieh; Weisskopf, Marc G.; Kosheleva, Anna; Spiro, Avron; Wang, Cuicui; Coull, Brent A.; Koutrakis, Petros; Schwartz, Joel

doi:10.1088/1748-9326/ac47c5

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…The presence of different covariates is important to note, given the number of studies that seek to adjust for community social characteristics and individual social, demographic, economic, and health characteristics. In some studies, area-level household income and house value modified the associations between ozone exposure and cognitive effects, with residents of lower-income or -house-value neighbourhoods having an increased response to ozone [38]. However, in [28], the emotional distress associated with (in particular) NO x was not confounded by socio-economic factors (age, geographical region, race/ethnicity, education, and income), lifestyle (smoking, alcohol, and physical activity), employment status or clinical characteristics [28].…”

Section: Overall Resultsmentioning

confidence: 99%

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A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty

Hodgson,

Benkowitz,

Castellani

et al. 2023

Environments

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Environmental and public health research has given considerable attention to the impact of air quality on brain health, with systematic reviews being widespread. No literature review has been conducted for cognitive frailty—a multidimensional syndrome combining physical frailty and cognitive impairment and their apparent co-dependence, linked to increased vulnerability and adverse health outcomes, including dementia. Instead, cognitive decline and frailty are implicitly explored through research on air quality and comorbid cognitive and physical decline in elderly populations. A scoping review was conducted to explore the need for a systematic review. Combining the Arksey and O’Malley, and PRISMA-ScR checklist, a scoping review of SCOPUS using ‘cogniti*’ + ‘resilience’ + ‘air quality’ or ‘cogniti*’ + ‘ageing’ + ‘air quality’ resulted in n = 2503 articles, screened and reduced using inclusion and exclusion criteria, to n = 16 articles. Air quality appears to be a critical risk factor for cognitive decline, even at air quality levels below WHO targets. Moderate long-term ambient air pollution appears linked to increased risk of cognitive frailty, suggesting earlier and more active interventions to protect older people. There are varied effects on cognition across the life course, with both emotional and functional impacts. Effects may be more detrimental to elderly people with existing conditions, including economic and health inequalities. Generalisation of results is limited due to the absence of a dose–response, variations in methods, controlling for comorbid effects, and variance across studies. No literature review has been performed for cognitive frailty, largely due to the fact that it is not presently treated as an explicit outcome. The findings support the need for more research and a more extensive summary of the literature but suggest that there is worsening cognitive function over the life course as a result of increased PM2.5 concentrations. Furthermore, air quality appears to be a critical risk factor even at levels below World Health Organisation targets.

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Section: Overall Resultsmentioning

confidence: 99%

“…Ref. [38] also notes a positive association between short to medium term (average one and four weeks) ambient exposure to gaseous pollutants (ozone and NO x ) and elevated psychiatric symptom intensity. One study provided limited population-based evidence for the oldest subjects and detected a threshold of 33 µgm −3 .…”

Section: Overall Resultsmentioning

confidence: 99%

A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty

Hodgson,

Benkowitz,

Castellani

et al. 2023

Environments

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“…22 Another recent study found impacts of exposures in the prior 1 and 4 weeks and increases in psychiatric symptoms in older adults. 60 We hypothesized that early-life air pollution would contribute to mental health symptoms in children during pre-and postnatal time windows, and early childhood. Given that the critical window remains unknown, the life stage at which these effects are most prominent could be at any point in pregnancy, infancy, or childhood.…”

Section: Discussionmentioning

confidence: 99%

“… 22 Another recent study found impacts of exposures in the prior 1 and 4 weeks and increases in psychiatric symptoms in older adults. 60 …”

Section: Discussionmentioning

confidence: 99%

Association between prenatal and childhood PM2.5 exposure and preadolescent anxiety and depressive symptoms

McGuinn,

Gutiérrez-Avila,

Rosa

et al. 2023

Environmental Epidemiology

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Background: Fine particulate matter (PM2.5) exposure has been linked to anxiety and depression in adults; however, there is limited research in the younger populations, in which symptoms often first arise. Methods: We examined the association between early-life PM2.5 exposure and symptoms of anxiety and depression in a cohort of 8–11-year-olds in Mexico City. Anxiety and depressive symptoms were assessed using the Spanish versions of the Revised Children’s Manifest Anxiety Scale and Children’s Depression Inventory. Daily PM2.5 was estimated using a satellite-based exposure model and averaged over several early and recent exposure windows. Linear and logistic regression models were used to estimate the change in symptoms with each 5-µg/m3 increase in PM2.5. Models were adjusted for child’s age, child’s sex, maternal age, maternal socioeconomic status, season of conception, and temperature. Results: Average anxiety and depressive symptom T-scores were 51.0 (range 33–73) and 53.4 (range 44–90), respectively. We observed consistent findings for exposures around the fourth year of life, as this was present for both continuous and dichotomized anxiety symptoms, in both independent exposure models and distributed lag modeling approaches. This window was also observed for elevated depressive symptoms. An additional consistent finding was for PM2.5 exposure during early pregnancy in relation to both clinically elevated anxiety and depressive symptoms, this was seen in both traditional and distributed lag modeling approaches. Conclusion: Both early life and recent PM2.5 exposure were associated with higher mental health symptoms in the child highlighting the role of PM2.5 in the etiology of these conditions.

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“…There is also emerging evidence that air pollutants may adversely affect cognitive development [ 45 ], cognitive performance [ 15 , 44 , 45 , 46 , 47 ], and stress [ 48 ] and psychological well-being [ 49 , 50 ]. Air pollution impairs verbal tests, and the effect becomes stronger as people age.…”

Section: Considerations and Discussionmentioning

confidence: 99%

Synergistic or Antagonistic Health Effects of Long- and Short-Term Exposure to Ambient NO2 and PM2.5: A Review

Mainka

Żak

2022

IJERPH

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Studies on adverse health effects associated with air pollution mostly focus on individual pollutants. However, the air is a complex medium, and thus epidemiological studies face many challenges and limitations in the multipollutant approach. NO2 and PM2.5 have been selected as both originating from combustion processes and are considered to be the main pollutants associated with traffic; moreover, both elicit oxidative stress responses. An answer to the question of whether synergistic or antagonistic health effects of combined pollutants are demonstrated by pollutants monitored in ambient air is not explicit. Among the analyzed studies, only a few revealed statistical significance. Exposure to a single pollutant (PM2.5 or NO2) was mostly associated with a small increase in non-accidental mortality (HR:1.01–1.03). PM2.5 increase of <10 µg/m3 adjusted for NO2 as well as NO2 adjusted for PM2.5 resulted in a slightly lower health risk than a single pollutant. In the case of cardiovascular heart disease, mortality evoked by exposure to PM2.5 or NO2 adjusted for NO2 and PM2.5, respectively, revealed an antagonistic effect on health risk compared to the single pollutant. Both short- and long-term exposure to PM2.5 or NO2 adjusted for NO2 and PM2.5, respectively, revealed a synergistic effect appearing as higher mortality from respiratory diseases.

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Associations between air pollution and psychiatric symptoms in the Normative Aging Study

Cited by 6 publications

References 34 publications

A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty

A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty

Association between prenatal and childhood PM2.5 exposure and preadolescent anxiety and depressive symptoms

Synergistic or Antagonistic Health Effects of Long- and Short-Term Exposure to Ambient NO2 and PM2.5: A Review

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