Associations between allergic diseases and attention deficit hyperactivity/oppositional defiant disorders in children

Lin, Yi Tsen; Chen, Yang Ching; Gau, Susan Shur‐Fen; Yeh, Te‐Huei; Fan, Hsien Yu; Hwang, Yu Ya; Lee, Yungling Leo

doi:10.1038/pr.2016.111

Cited by 47 publications

(37 citation statements)

References 33 publications

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“…23 Holmberg et al 24 studied multiple types of asthma and ADHD concluded that asthma was associated equally with attention and hyperactivity and the association was not restricted to either of the two dimensions of ADHD. Also, Yi-Tsen et al 5 demonstrated that children (aged 9-10 y old) having symptoms of asthma within the past 1 y were associated with having all dimensions of symptoms of ADHD. In our study asthma associated with attention and hyperactivity but not combined type.…”

Section: Discussionmentioning

confidence: 99%

“…3 Recently, it has been suggested that asthma may be a risk factor for Oppositional Defiant Disorder (ODD), Attention Deficit Hyperactivity Disorder (ADHD) and Conduct Disorder (CD), that cause physical and emotional problems, long-term school absence, and social problems. 4,5 Psychological comorbidities and behavioral conditions are increasingly recognized as important determinants of asthma management and prognosis as these are associated with inadequate disease control, higher health care use, and poor quality of life. [6][7][8] Moreover, the recurrent exacerbations of asthma are associated with specific co-morbidities that require additional therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

“…9 Uncontrolled ADHD and ODD may result in several complications, including the persistence of symptoms into adolescence or adulthood, poor social skills, depression, or even criminal activity. 5 Although a considerable number of studies have documented the prevalence of comorbidities in asthma patients, the data of the Iranian population is scarce. Therefore, the current study assessed the prevalence of psychopathology in children with asthma focusing on ODD, ADHD, and CD using research diagnostic interviews according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) scales.…”

Section: Introductionmentioning

confidence: 99%

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Associations of Behavioral Disorders with Asthma in Iranian Children

Tajdini

Effatpanah

Zaki‐Dizaji

et al. 2019

IJAAI

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Asthma is a common respiratory disease with huge economic burden leading to activity limitations, morbidity, and mortality. In this study, we aim to investigate the prevalence of Oppositional Defiant Disorder (ODD), Attention Deficit Hyperactivity Disorder (ADHD) and Conduct Disorder (CD) among children with asthma. This case-control study was performed in a pediatric referral health care center (Children's Medical Center in Tehran University of Medical Sciences) in 2017.With random selection, the 80 children with asthma and 92 controls with age range of 5 to 11 years were enrolled in this study. In addition to the demographic information and family history of allergy, asthma symptoms, and control quality evaluated with a validated Childhood Asthma Control Test (C-ACT). The mode of measurement for ADHD, ODD and CD was based on Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) psychiatric scales from clinical interviews conducted by child psychiatrists. Totally, 42.5% and 25% in the case and control groups had ADHD respectively with significant difference (p=0.01). Also, 25% and 5.4% in the case and control groups had ODD respectively with significant difference (p=0.001). But conduct disorder was 10% and 10.9% in case and control groups respectively without significant difference (p=0.8). Children with asthma were associated with exhibiting ADHD and ODD but not CD. Therefore, appropriate evaluation and treatment are needed for asthmatic children with attention-deficit and ODD symptoms. Besides, further research is needed to determine the etiological approach towards ADHD, ODD and asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of Behavioral Disorders with Asthma in Iranian Children

Tajdini

Effatpanah

Zaki‐Dizaji

et al. 2019

IJAAI

View full text Add to dashboard Cite

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“…In addition, emerging literature has shown that some individuals with ADHD have a higher concurrence of immune-related comorbidities, such as asthma and atopic dermatitis (AD); thus, an immune-related cause for ADHD has been proposed. [22][23][24][25][26][27][28] At the same time, MF nonionizing radiation exposure has been reported to have an association with the immune system. 9,29-33 Thus, it is conceivable that in utero exposure to MF nonionizing radiation may specifically increase the risk of ADHD with an underlying immune cause.…”

Section: Outcome Measurement: Adhd Diagnosis and Immune-related Comormentioning

confidence: 97%

Association Between Maternal Exposure to Magnetic Field Nonionizing Radiation During Pregnancy and Risk of Attention-Deficit/Hyperactivity Disorder in Offspring in a Longitudinal Birth Cohort

Chen

Ferber

et al. 2020

JAMA Netw Open

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IMPORTANCE An association between maternal exposure to magnetic field (MF) nonionizing radiation during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) has been reported in both animal and human studies.OBJECTIVES To determine whether maternal exposure to high levels of MF nonionizing radiation is associated with an increased risk of ADHD in offspring by using more accurate measurements of MF nonionizing radiation levels and physician-diagnosed ADHD, rather than self-reports, and to determine whether the association differs for the subtypes of ADHD with or without immune-related comorbidities. DESIGN, SETTING, AND PARTICIPANTS A longitudinal birth cohort study was conducted at KaiserPermanente Northern California among 1482 mother-child pairs whose mothers were participants of an existing birth cohort and whose level of exposure to MF nonionizing radiation was captured during pregnancy in 2 studies conducted from EXPOSURE All participating women wore a monitoring meter for 24 hours during pregnancy to capture the level of exposure to MF nonionizing radiation from any sources. MAIN OUTCOMES AND MEASURESPhysician-diagnosed ADHD and immune-related comorbidities of asthma or atopic dermatitis up to 20 years of age in offspring captured in the Kaiser Permanente Northern California electronic medical record from May 1, 1997, to December 31, 2017.Confounders were ascertained during in-person interviews during pregnancy. RESULTSAmong the 1454 mother-child pairs (548 white [37.7%], 110 African American [7.6%], 325 Hispanic [22.4%], 376 Asian or Pacific Islander [25.9%], and 95 other or unknown [6.5%]; mean [SD] maternal age, 31.4 [5.4] years]), 61 children (4.2%) had physician-diagnosed ADHD. Using Coxproportional hazards regression to account for follow-up time and confounders, compared with children whose mothers had a low level of exposure to MF nonionizing radiation during pregnancy, children whose mothers were exposed to higher levels of MF nonionizing radiation had more than twice the risk of ADHD (adjusted hazard ratio [aHR], 2.01; 95% CI, 1.06-3.81). The association was stronger for ADHD that persisted into adolescence (Ն12 years of age), with an aHR of 3.38 (95% CI, 1.43-8.02). When the subtypes of ADHD were examined, the association existed primarily for ADHD with immune-related comorbidities (asthma or atopic dermatitis), with an aHR of 4.57 (95% CI, 1.61-12.99) for all ADHD cases and an aHR of 8.27 (95% CI, 1.96-34.79) for persistent cases of ADHD. (continued) Key Points Question Could human exposure to magnetic field nonionizing radiation be associated with increased risk of attention-deficit/hyperactivity disorder in children? Findings This birth cohort study found a statistically significant association between a high level of maternal exposure to magnetic field nonionizing radiation, as captured with a monitoring meter, during pregnancy and an increased risk of attention-deficit/ hyperactivity disorder in offspring. The association was stronger for children who received a diagnosi...

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“…Recently, researchers have paid close attention to the connection between ADHD and allergic disease (32,33). Previous reports have revealed potential associations between ADHD and allergic diseases (34)(35)(36). AE, AR, and allergic asthma are considered to be the most common chronic diseases worldwide and represent the three major clinical manifestations of atopy (37).…”

Section: Potential Relationship Between Adhd and Allergic Diseasementioning

confidence: 99%

Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease

Zhou

Wang

Sun

et al. 2017

Molecular Medicine Reports

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Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder. Previous research has indicated that genetic factors, family education, environment and dietary habits are associated with ADHD. It has been determined that in China many children with ADHD also have allergic rhinitis or asthma. These children are more susceptible to the common cold or upper respiratory infections compared with normal healthy children. Additionally, the common cold or an upper respiratory infection may lead to disease recurrence or worsen the symptoms in these children. Previous studies have determined that ADHD may have a close association with allergic disease. Based on the clinically observed phenomenon and previous studies, it was hypothesized that ADHD is a high inflammation and immune‑associated disease. Therefore, the authors designed clinical and animal experiments to test this hypothesis in the future. Immune system disorders may be a novel part of the etiology of ADHD. The current report may have implications for future clinical practice.

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Associations between allergic diseases and attention deficit hyperactivity/oppositional defiant disorders in children

Cited by 47 publications

References 33 publications

Associations of Behavioral Disorders with Asthma in Iranian Children

Associations of Behavioral Disorders with Asthma in Iranian Children

Association Between Maternal Exposure to Magnetic Field Nonionizing Radiation During Pregnancy and Risk of Attention-Deficit/Hyperactivity Disorder in Offspring in a Longitudinal Birth Cohort

Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease

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