Associations between body mass index in different childhood age periods and hyperuricemia in young adulthood: the China Health and Nutrition Survey cohort study

Qian, Yi; Kong, Yawei; Wan, Naijun; Yan, Yinkun

doi:10.1007/s12519-022-00573-x

Cited by 5 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, the associations of childhood BMI z score with ≥1 cardiometabolic disorders, ≥2 cardiometabolic disorders, and elevated BP in adulthood began to be significant from age 6; the association for low HDL-C and IR began to be significant from age 10; and the association for elevated TG and elevated ALT began to be significant from age 13. Our previous study found that the association between adult hyperuricemia and childhood BMI was statistically significant from age 16 [24].…”

Section: Discussionmentioning

confidence: 90%

BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood

Qian

Kong

Wan

et al. 2023

Obesity

Self Cite

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to investigate when the association between childhood obesity and adult cardiometabolic disorders starts to be operative.MethodsThe study cohort included 811 participants who had data on blood pressure, lipid profile, fasting blood glucose, fasting insulin, or alanine aminotransferase in adulthood and had at least one measurement of BMI in childhood.ResultsChildhood BMI z score was significantly associated with increased risks of ≥1 cardiometabolic disorders, ≥2 cardiometabolic disorders, and elevated blood pressure in adulthood for age groups of 6 to 9 years, 10 to 12 years, 13 to 15 years, and 16 to 18 years, after adjustment for covariates. For low high‐density lipoprotein cholesterol, significant associations were observed for age groups of 10 to 12 years, 13 to 15 years, and 16 to 18 years. For elevated triglyceride and elevated alanine aminotransferase, significant associations were observed for age groups of 13 to 15 years and 16 to 18 years. For insulin resistance, significant associations were observed for age groups of 10 to 12 years and 16 to 18 years. For elevated total cholesterol, elevated low‐density lipoprotein cholesterol, or elevated fasting blood glucose, no association was observed in any age group.ConclusionsThe association between childhood BMI and adult cardiometabolic disorders begins to be operative from early life. These results support universal screening of childhood obesity starting at an early age.

show abstract

Section: Discussionmentioning

confidence: 90%

BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood

Qian

Kong

Wan

et al. 2023

Obesity

Self Cite

View full text Add to dashboard Cite

show abstract

“…HUA was defined as the fasting serum UA level greater than 420 μmol/L (7 mg/dL) for boys and greater than 360 μmol/L (6 mg/dL) for girls. 25,26…”

Section: Study Populationmentioning

confidence: 99%

A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity

Liu,

Cao,

Luo

et al. 2024

DMSO

View full text Add to dashboard Cite

To explore the gender-, age-, and weight status-specific prevalence of hyperuricemia (HUA) and its associated risk factors among Chinese children and adolescents with obesity. Methods: A total of 1329 children aged 2-17 years, who were diagnosed with obesity and hospitalized in our center from January 2016 to December 2022 were recruited. They were divided into mild obesity, moderate obesity, and severe obesity groups. HUA was defined as fasting serum uric acid level >420 μmol/L for boys and >360 μmol/L for girls. Multivariate logistic regression analyses were performed to identify risk factors for HUA. Results: The highest proportion of hospitalized obese children was aged 10-13 years comprising 677 (50.9%) followed by those aged 6-9 years comprising 348 (26.2%) whereas the least proportion was aged 2-5 years comprising 76 (5.7%). The above differences in age distribution were still present in subgroup analyses according to weight status. Most hospitalized obese children were boys (64.7%), especially in the severe obesity group (75.0%). The overall estimated prevalence of HUA in obese children was 54.8%. It presented a gradual increase trend over the last 7 years, with more rapidly in boys than in girls. Subgroup analysis by weight status showed that the prevalence of HUA was higher in children with moderate obesity (64.3%) and severe obesity (64.2%) when compared with mild obesity (48.2%) (P all<0.01). Boys reached a relatively high HUA incidence level (≥60%) at age 12, which occurred about 2 years later than in girls (age 10). With 12 years as the cut-off point, a high prevalence of HUA (≥60%) was observed in both genders. Multivariable logistic regression analyses showed that boy (OR=2.844, 95% CI 2.024-3.998), age (OR=1.253, 95% CI 1.155-1.360), BMI-Z score (OR=2.132, 95% CI 1.438-3.162), fasting blood glucose (OR=0.907, 95% CI 0.860-0.956), phosphorus (OR=4.123, 95% CI 2.349-7.239), alkaline phosphatase (OR=1.002, 95% CI 1.001-1.004), creatinine (OR=1.067, 95% CI 1.037-1.098), urea nitrogen (OR=1.193, 95% CI 1.032-1.378), aspartate aminotransferase (OR=1.016, 95% CI 1.002-1.030), triglycerides (OR=1.339, 95% CI 1.075-1.667), and high-density lipoprotein cholesterol (OR=0.381, 95% CI 0.160-0.910) were independently associated with odds of HUA (P all<0.05). Conclusion:The prevalence of HUA in Chinese obese children and adolescents is unexpectedly high. Childhood HUA was significantly associated with obesity. Gender and age differences were observed in the association between childhood obesity and HUA. Obese children aged ≥12 years should be focused on screening the risk of HUA.

show abstract

Growth and development of children in China: achievements, problems and prospects

Zong,

2023

World J Pediatr

View full text Add to dashboard Cite

Associations between body mass index in different childhood age periods and hyperuricemia in young adulthood: the China Health and Nutrition Survey cohort study

Cited by 5 publications

References 34 publications

BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood

BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood

A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity

Growth and development of children in China: achievements, problems and prospects

Contact Info

Product

Resources

About